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• W2035664252 abstract "Uvaria chamae is a well known medicinal plant in Nigerian tradit ional medicine for the management of many diseases, but investigations concerning its ph armacological characteristics are rare. In this stu dy, we evaluate its venom neutralizing properties again st Naja nigricollis venom in rats. Freshly collected Uvaria chamae leaves were air dried, powdered and extracted in m ethanol. To study the antivenom properties, albino rats were orally administered wi th a dose of 400 mg kg -1 body weight and one hour later, the venom was administered intraperitoneally at a dose of 0.08 mg kg -1 body weight of rats. Albino rats (male) weighing between 180-200g were randomly divided into five (5) groups of three (3). Groups 1-5 received water, normal saline, venom, Uvaria chamae and venom, Uvaria chamae respectively. Blood clothing time, bleeding time, antipyretic act ivity, haemoglobin, RBC, WBC, creatine kinase, AST, ALP and ALT activities total protein antioxidant ac tivity and some blood electrolytes, plasma urea and uric acid were measured. Our results showed that Uvaria chamae methanol extract neutralized some biological effects of Naja nigricollis venom. The venom increased the rectal temperature, enzyme activities, bleeding time and other blood parameter s. The plant extract was able to reduce these parameters in the extract treated groups. Details o f the results are discussed. From this study, it is clear that U. chamae leaf extract had antivenom activity in animal mode ls. The above results indicate that the plant extract possess potent snake venom neutralizi ng capacity and could potentially be used for therapeutic purpose in case of snake bite envenomat ion." @default.
• W2035664252 created "2016-06-24" @default.
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• W2035664252 date "2013-03-01" @default.
• W2035664252 modified "2023-09-23" @default.
• W2035664252 title "<I>IN VIVO</I> NEUTRALIZATION OF <I>NAJA NIGRICOLLIS</I> VENOM BY <I>UVARIA CHAMAE</I>" @default.
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• W2035664252 doi "https://doi.org/10.3844/ajbbsp.2013.224.234" @default.
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