Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035671623> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2035671623 endingPage "338" @default.
- W2035671623 startingPage "319" @default.
- W2035671623 abstract "Proper development of the skeleton in utero and during growth requires mechanical stimulation. Loading results in adaptive changes in bone that strengthen bone structure. Bone’s adaptive response is regulated by the ability of resident bone cells to perceive and translate mechanical energy into a cascade of structural and biochemical changes within the cells a process known as mechanotransduction. Mechanotransduction pathways are among the most anabolic in bone, and consequently, there is great interest in elucidating how mechanical loading produces its observed effects, including increased bone formation, reduced bone loss, changes in bone cell differentiation and lifespan, among others. A molecular understanding of these processes is developing, and with it comes a profound new insight into the biology of bone. In this article, we review the nature of the physical stimulus to which bone cells mount an adaptive response, including the identity of the sensor cells, their attributes and physical environment, and putative mechanoreceptors they express. Particular attention is allotted to the focal adhesion and Wnt signaling, in light of their emerging role in bone mechanotransduction. Te cellular mechanisms for increased bone loss during disuse, and reduced bone loss during loading are considered. Finally, we summarize the published data on bone cell accommodation, whereby bone cells stop responding to mechanical signaling events. Collectively, these data highlight the complex yet finely orchestrated process of mechanically regulated bone homeostasis." @default.
- W2035671623 created "2016-06-24" @default.
- W2035671623 creator A5041978225 @default.
- W2035671623 creator A5091677589 @default.
- W2035671623 date "2009-01-01" @default.
- W2035671623 modified "2023-10-18" @default.
- W2035671623 title "Mechanical Signaling for Bone Modeling and Remodeling" @default.
- W2035671623 doi "https://doi.org/10.1615/critreveukargeneexpr.v19.i4.50" @default.
- W2035671623 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3743123" @default.
- W2035671623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19817708" @default.
- W2035671623 hasPublicationYear "2009" @default.
- W2035671623 type Work @default.
- W2035671623 sameAs 2035671623 @default.
- W2035671623 citedByCount "273" @default.
- W2035671623 countsByYear W20356716232012 @default.
- W2035671623 countsByYear W20356716232013 @default.
- W2035671623 countsByYear W20356716232014 @default.
- W2035671623 countsByYear W20356716232015 @default.
- W2035671623 countsByYear W20356716232016 @default.
- W2035671623 countsByYear W20356716232017 @default.
- W2035671623 countsByYear W20356716232018 @default.
- W2035671623 countsByYear W20356716232019 @default.
- W2035671623 countsByYear W20356716232020 @default.
- W2035671623 countsByYear W20356716232021 @default.
- W2035671623 countsByYear W20356716232022 @default.
- W2035671623 countsByYear W20356716232023 @default.
- W2035671623 crossrefType "journal-article" @default.
- W2035671623 hasAuthorship W2035671623A5041978225 @default.
- W2035671623 hasAuthorship W2035671623A5091677589 @default.
- W2035671623 hasBestOaLocation W20356716232 @default.
- W2035671623 hasConcept C12021080 @default.
- W2035671623 hasConcept C133605539 @default.
- W2035671623 hasConcept C134018914 @default.
- W2035671623 hasConcept C137620995 @default.
- W2035671623 hasConcept C169760540 @default.
- W2035671623 hasConcept C170033053 @default.
- W2035671623 hasConcept C181104049 @default.
- W2035671623 hasConcept C185592680 @default.
- W2035671623 hasConcept C202751555 @default.
- W2035671623 hasConcept C2776033226 @default.
- W2035671623 hasConcept C2776541429 @default.
- W2035671623 hasConcept C2778260815 @default.
- W2035671623 hasConcept C2780171871 @default.
- W2035671623 hasConcept C2780973866 @default.
- W2035671623 hasConcept C55493867 @default.
- W2035671623 hasConcept C62478195 @default.
- W2035671623 hasConcept C673006 @default.
- W2035671623 hasConcept C86803240 @default.
- W2035671623 hasConcept C95444343 @default.
- W2035671623 hasConceptScore W2035671623C12021080 @default.
- W2035671623 hasConceptScore W2035671623C133605539 @default.
- W2035671623 hasConceptScore W2035671623C134018914 @default.
- W2035671623 hasConceptScore W2035671623C137620995 @default.
- W2035671623 hasConceptScore W2035671623C169760540 @default.
- W2035671623 hasConceptScore W2035671623C170033053 @default.
- W2035671623 hasConceptScore W2035671623C181104049 @default.
- W2035671623 hasConceptScore W2035671623C185592680 @default.
- W2035671623 hasConceptScore W2035671623C202751555 @default.
- W2035671623 hasConceptScore W2035671623C2776033226 @default.
- W2035671623 hasConceptScore W2035671623C2776541429 @default.
- W2035671623 hasConceptScore W2035671623C2778260815 @default.
- W2035671623 hasConceptScore W2035671623C2780171871 @default.
- W2035671623 hasConceptScore W2035671623C2780973866 @default.
- W2035671623 hasConceptScore W2035671623C55493867 @default.
- W2035671623 hasConceptScore W2035671623C62478195 @default.
- W2035671623 hasConceptScore W2035671623C673006 @default.
- W2035671623 hasConceptScore W2035671623C86803240 @default.
- W2035671623 hasConceptScore W2035671623C95444343 @default.
- W2035671623 hasIssue "4" @default.
- W2035671623 hasLocation W20356716231 @default.
- W2035671623 hasLocation W20356716232 @default.
- W2035671623 hasLocation W20356716233 @default.
- W2035671623 hasLocation W20356716234 @default.
- W2035671623 hasOpenAccess W2035671623 @default.
- W2035671623 hasPrimaryLocation W20356716231 @default.
- W2035671623 hasRelatedWork W108250234 @default.
- W2035671623 hasRelatedWork W116611883 @default.
- W2035671623 hasRelatedWork W1594526962 @default.
- W2035671623 hasRelatedWork W2016390309 @default.
- W2035671623 hasRelatedWork W2206562330 @default.
- W2035671623 hasRelatedWork W2283105156 @default.
- W2035671623 hasRelatedWork W2343705381 @default.
- W2035671623 hasRelatedWork W2401622792 @default.
- W2035671623 hasRelatedWork W2559481572 @default.
- W2035671623 hasRelatedWork W2612273899 @default.
- W2035671623 hasVolume "19" @default.
- W2035671623 isParatext "false" @default.
- W2035671623 isRetracted "false" @default.
- W2035671623 magId "2035671623" @default.
- W2035671623 workType "article" @default.