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- W2035674932 abstract "Background: The effect of the dose of carvedilol on cardiac sympathetic nerve activity (CSA) and mortality remain uncertain in patients with chronic heart failure (CHF). Methods and Results: To compare the dose of carvedilol and the transcardiac gradient of norepinephrine (NE), a biomarker of CSA, and prognosis in patients with CHF, hemodynamic parameters and plasma levels of NE, N-terminal brain natriuretic peptide (NT-proBNP) in the aortic root and coronary sinus were measured in 107 patients with systolic CHF who received carvedilol. Patients were divided into 2 groups [group I: low dose (<10 mg/day, n=41) and group II: high dose (≥10 mg/day, n=66)]. There was no difference between the 2 groups for the hemodynamic parameters. The dose of carvedilol did not correlate with plasma NE, but was significantly correlated with the transcardiac increase in NE. During a median follow-up of 4.3 years, 13 patients died of cardiac disease. In the Cox stepwise multivariate analyses, a high level of transcardiac increase in NE (P<0.001), high level of plasma log NT-proBNP (P=0.004) and low dose of carvedilol (P=0.012) were significant independent predictors. Conclusion: The carvedilol dose is important for the management of CSA and prognosis in patients with systolic CHF. (Circ J 2009; 73: 2270-2275)" @default.
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- W2035674932 date "2009-01-01" @default.
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- W2035674932 title "Dose-Dependent Prognostic Effect of Carvedilol in Patients With Chronic Heart Failure Special Reference to Ranscardiac Gradient of Norepinephrine" @default.
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- W2035674932 doi "https://doi.org/10.1253/circj.cj-09-0456" @default.
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