FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035691702> ?p ?o ?g. }

• W2035691702 endingPage "156" @default.
• W2035691702 startingPage "147" @default.
• W2035691702 abstract "The immunomodulatory effects of three compounds designated BS, GS, and YS produced by Pestalotiopsis leucothës, an endophytic fungus isolated from Tripterygium wilfordii, were evaluated. The 50% inhibition concentration (IC50) value of BS in the proliferative assay with various stimulating agents such as phytohemagglutinin-M (PHA-M), phorbol myristate acetate (PMA)/ionomycin, mixed lymphocyte reaction (MLR) and poke weed mitogen (PWM) was 0.35, 1.6, 0.8 and 5.4 μg/ml, respectively. In addition, BS significantly inhibited the production of cytokines such as interleukin (IL)-1β, IL-2, interferon (IFN)-γ and tumor necrosis factor (TNF)-α, by peripheral blood mononuclear cells (PBMNC) and soluble IL-2 receptor expression at concentrations greater than 1 μg/ml. Inhibition of PHA stimulated PBMNC proliferation and IL-2 and sIL-2R production by BS indicates that it is a T-cell specific immunosuppressant. However, BS also moderately inhibited immunoglobulin (Ig) G and M at concentrations greater than 1 μg/ml suggesting that it also has B cell immunosuppressive effects. YS was 10% less active than BS in all assay systems. In contrast, GS exhibited both suppression and enhancement of PBMNC proliferation in the presence of various stimulants. However, GS inhibited PWM stimulated PBMNC proliferation and IL-4 and IgG and IgM production at concentrations above 1 μg/ml. All three fungal compounds altered the percentage of T-lymphocyte subpopulations only at high concentrations. Cell viability was not affected at the immunosuppressive concentrations of these compounds. In conclusion, work from our laboratory has identified three potentially potent immunomodulatory compounds from P. leucothës. These compounds have variable effects on T- and B-cells and monocytes. They may partially explain the immunosuppressive activity of T. wilfordii. In addition, they may represent a new source of immunomodulatory compounds for the treatment of human immune mediated diseases." @default.
• W2035691702 created "2016-06-24" @default.
• W2035691702 creator A5004488408 @default.
• W2035691702 creator A5008971734 @default.
• W2035691702 creator A5036256284 @default.
• W2035691702 creator A5086328096 @default.
• W2035691702 creator A5087515883 @default.
• W2035691702 date "2005-11-01" @default.
• W2035691702 modified "2023-10-01" @default.
• W2035691702 title "Immunomodulatory compounds from Pestalotiopsis leucothës, an endophytic fungus from Tripterygium wilfordii" @default.
• W2035691702 cites W1968698104 @default.
• W2035691702 cites W1971633763 @default.
• W2035691702 cites W1975160937 @default.
• W2035691702 cites W1993596576 @default.
• W2035691702 cites W2003752950 @default.
• W2035691702 cites W2005240394 @default.
• W2035691702 cites W2007725567 @default.
• W2035691702 cites W2012246946 @default.
• W2035691702 cites W2014670086 @default.
• W2035691702 cites W2017605032 @default.
• W2035691702 cites W2023466603 @default.
• W2035691702 cites W2026108503 @default.
• W2035691702 cites W2029741715 @default.
• W2035691702 cites W2036234818 @default.
• W2035691702 cites W2040259039 @default.
• W2035691702 cites W2041814940 @default.
• W2035691702 cites W2051730992 @default.
• W2035691702 cites W2053798662 @default.
• W2035691702 cites W2061904336 @default.
• W2035691702 cites W2063534490 @default.
• W2035691702 cites W2084570982 @default.
• W2035691702 cites W2092305254 @default.
• W2035691702 cites W2099556958 @default.
• W2035691702 cites W2112710124 @default.
• W2035691702 cites W2115236769 @default.
• W2035691702 cites W2136249549 @default.
• W2035691702 cites W2137914523 @default.
• W2035691702 cites W2164717705 @default.
• W2035691702 cites W2315377404 @default.
• W2035691702 cites W2316695139 @default.
• W2035691702 cites W4206163632 @default.
• W2035691702 doi "https://doi.org/10.1016/j.lfs.2005.04.050" @default.
• W2035691702 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16107268" @default.
• W2035691702 hasPublicationYear "2005" @default.
• W2035691702 type Work @default.
• W2035691702 sameAs 2035691702 @default.
• W2035691702 citedByCount "35" @default.
• W2035691702 countsByYear W20356917022012 @default.
• W2035691702 countsByYear W20356917022013 @default.
• W2035691702 countsByYear W20356917022014 @default.
• W2035691702 countsByYear W20356917022015 @default.
• W2035691702 countsByYear W20356917022016 @default.
• W2035691702 countsByYear W20356917022017 @default.
• W2035691702 countsByYear W20356917022018 @default.
• W2035691702 countsByYear W20356917022019 @default.
• W2035691702 countsByYear W20356917022020 @default.
• W2035691702 countsByYear W20356917022021 @default.
• W2035691702 countsByYear W20356917022022 @default.
• W2035691702 countsByYear W20356917022023 @default.
• W2035691702 crossrefType "journal-article" @default.
• W2035691702 hasAuthorship W2035691702A5004488408 @default.
• W2035691702 hasAuthorship W2035691702A5008971734 @default.
• W2035691702 hasAuthorship W2035691702A5036256284 @default.
• W2035691702 hasAuthorship W2035691702A5086328096 @default.
• W2035691702 hasAuthorship W2035691702A5087515883 @default.
• W2035691702 hasConcept C137061746 @default.
• W2035691702 hasConcept C142724271 @default.
• W2035691702 hasConcept C153911025 @default.
• W2035691702 hasConcept C185592680 @default.
• W2035691702 hasConcept C195794163 @default.
• W2035691702 hasConcept C202751555 @default.
• W2035691702 hasConcept C203014093 @default.
• W2035691702 hasConcept C204787440 @default.
• W2035691702 hasConcept C2776989580 @default.
• W2035691702 hasConcept C2778690821 @default.
• W2035691702 hasConcept C2780043322 @default.
• W2035691702 hasConcept C2780695664 @default.
• W2035691702 hasConcept C55493867 @default.
• W2035691702 hasConcept C62478195 @default.
• W2035691702 hasConcept C71924100 @default.
• W2035691702 hasConcept C86803240 @default.
• W2035691702 hasConcept C98274493 @default.
• W2035691702 hasConceptScore W2035691702C137061746 @default.
• W2035691702 hasConceptScore W2035691702C142724271 @default.
• W2035691702 hasConceptScore W2035691702C153911025 @default.
• W2035691702 hasConceptScore W2035691702C185592680 @default.
• W2035691702 hasConceptScore W2035691702C195794163 @default.
• W2035691702 hasConceptScore W2035691702C202751555 @default.
• W2035691702 hasConceptScore W2035691702C203014093 @default.
• W2035691702 hasConceptScore W2035691702C204787440 @default.
• W2035691702 hasConceptScore W2035691702C2776989580 @default.
• W2035691702 hasConceptScore W2035691702C2778690821 @default.
• W2035691702 hasConceptScore W2035691702C2780043322 @default.
• W2035691702 hasConceptScore W2035691702C2780695664 @default.
• W2035691702 hasConceptScore W2035691702C55493867 @default.
• W2035691702 hasConceptScore W2035691702C62478195 @default.
• W2035691702 hasConceptScore W2035691702C71924100 @default.
• W2035691702 hasConceptScore W2035691702C86803240 @default.

• next