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• W2035694595 abstract "Leech embryogenesis is a model for investigating cellular and molecular processes of development. Due to the unusually large size of embryonic stem cells (teloblasts: 50–300 <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>μ</mml:mi></mml:math>m) in the glossiphoniid leech, Theromyzon tessulatum , and the presence of identifiable stem cell precursors (proteloblasts), we previously isolated a group of genes upregulated upon stem cell birth. In the current study, we show that one of these genes, designated Theromyzon proliferation ( Tpr ), is required for normal stem cell genesis; specifically, transient Tpr knockdown experiments conducted with antisense oligonucleotides and monitored by semiquantitative RT-PCR, caused abnormal proteloblast proliferation leading to embryonic death, but did not overtly affect neuroectodermal or mesodermal stem cell development once these cells were born. Tpr encodes a large glutamine-rich (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mo>∼</mml:mo></mml:mrow></mml:math>34%) domain that shares compositional similarity with strong transcriptional enhancers many of which have been linked with trinucleotide repeat disorders (e.g., Huntington's)." @default.
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• W2035694595 date "2010-01-01" @default.
• W2035694595 modified "2023-09-29" @default.
• W2035694595 title "A Glutamine-Rich Factor Affects Stem Cell Genesis in Leech" @default.
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• W2035694595 doi "https://doi.org/10.4061/2010/145183" @default.
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