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- W2035702943 endingPage "772" @default.
- W2035702943 startingPage "761" @default.
- W2035702943 abstract "More than 3000 synthetic analogues of the biologically active form of vitamin D, 1α,25-dihydroxyvitamin D3 (1α,25-(OH)2-D3), are presently known. All analogues interact with the molecular switch controlling nuclear 1α,25-(OH)2-D3 signalling, which is the complex of the vitamin D receptor (VDR), the retinoid X receptor (RXR) and a 1α,25-(OH)2-D3 response element (VDRE). The central element of this molecular switch is the ligand-binding domain (LBD) of the VDR, which can be stabilised by a 1α,25-(OH)2-D3 analogue in either its agonistic or antagonistic conformation. In this article, the patent literature on 1α,25-(OH)2-D3 analogues described in the last 4 years will be reviewed, and several new VDR ligands with promising selective profiles discussed. Although most of these ligands are agonists of the VDR, a few antagonists have been reported. Non-steroidal VDR ligands will be highlighted, as well as 1α,25-(OH)2-D3 analogues with two side chains." @default.
- W2035702943 created "2016-06-24" @default.
- W2035702943 creator A5029809117 @default.
- W2035702943 creator A5035613777 @default.
- W2035702943 date "2003-06-01" @default.
- W2035702943 modified "2023-10-18" @default.
- W2035702943 title "New vitamin D receptor ligands" @default.
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- W2035702943 doi "https://doi.org/10.1517/13543776.13.6.761" @default.
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