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• W2035707919 endingPage "2308" @default.
• W2035707919 startingPage "2303" @default.
• W2035707919 abstract "A transcriptional silencer has been identified in the 5′ regulatory region of the human urokinase plasminogen activator (uPA) gene. This region Is able to block transcription from the human u-PA as well as the rabbit β-globln promoters in a cell type specific and orientation Independent way. The silencer Is enhancer dependent and is active in two cell lines (HeLa and CV-1) which produce little if any uPA, but not in the high uPA producer PC3. Silencing activity and enhancer dependence can be separated: the silencing activity has been localized to the DNA fragment - 660 to - 536, while the enhancer dependence is located in the - 536 to - 308 fragment. The DNA sequence of the silencer region contains an element that closely resembles the TGF-β responsive negative element TIE." @default.
• W2035707919 created "2016-06-24" @default.
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• W2035707919 date "1991-01-01" @default.
• W2035707919 modified "2023-09-23" @default.
• W2035707919 title "A cell-type specific and enhancer-dependent silencer in the regulation of the expression of the human urokinase plasminogen activator gene" @default.
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• W2035707919 doi "https://doi.org/10.1093/nar/19.9.2303" @default.
• W2035707919 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/329434" @default.
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