Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035708390> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2035708390 endingPage "644" @default.
- W2035708390 startingPage "640" @default.
- W2035708390 abstract "The aim of the present study was to assess the effect of food on the pharmacokinetics of entecavir (CAS 142217-69-4) from dispersible tablets. In an open-label, two-way crossover study, 12 healthy Chinese volunteers randomly received a single oral dose of 1 mg entecavir dispersible tablets under fasted and fed conditions. Blood samples were collected and determined for pharmacokinetic analyses. A solid phase extraction for sample preparation and a LC/MS method were developed and validated for determination of entecavir in human plasma. The absorption of entecavir from dispersible tablets was altered significantly with food intake, as evidenced by a decrease in C<sub>max</sub> of 63%, a decrease in AUC<sub>0–t</sub> of 22%, and a delay in T<sub>max</sub> of 1.5 h. The calibration curve was linear from 0.2 to 25 ng/mL, with a lower limit of quantitation (LLOQ) of 0.2 ng/mL. Food intake has an obvious effect on the absorption of entecavir from dispersible tablets. It is better to take entecavir dispersible tablets on an empty stomach." @default.
- W2035708390 created "2016-06-24" @default.
- W2035708390 creator A5006586061 @default.
- W2035708390 creator A5030138668 @default.
- W2035708390 creator A5049421341 @default.
- W2035708390 creator A5075139717 @default.
- W2035708390 creator A5086483815 @default.
- W2035708390 creator A5090013659 @default.
- W2035708390 date "2011-12-03" @default.
- W2035708390 modified "2023-10-16" @default.
- W2035708390 title "Food effect on the pharmacokinetics of entecavir from dispersible tablets following oral administration in healthy Chinese volunteers" @default.
- W2035708390 doi "https://doi.org/10.1055/s-0031-1296339" @default.
- W2035708390 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21125816" @default.
- W2035708390 hasPublicationYear "2011" @default.
- W2035708390 type Work @default.
- W2035708390 sameAs 2035708390 @default.
- W2035708390 citedByCount "8" @default.
- W2035708390 countsByYear W20357083902012 @default.
- W2035708390 countsByYear W20357083902017 @default.
- W2035708390 countsByYear W20357083902018 @default.
- W2035708390 countsByYear W20357083902019 @default.
- W2035708390 countsByYear W20357083902023 @default.
- W2035708390 crossrefType "journal-article" @default.
- W2035708390 hasAuthorship W2035708390A5006586061 @default.
- W2035708390 hasAuthorship W2035708390A5030138668 @default.
- W2035708390 hasAuthorship W2035708390A5049421341 @default.
- W2035708390 hasAuthorship W2035708390A5075139717 @default.
- W2035708390 hasAuthorship W2035708390A5086483815 @default.
- W2035708390 hasAuthorship W2035708390A5090013659 @default.
- W2035708390 hasBestOaLocation W20357083902 @default.
- W2035708390 hasConcept C112705442 @default.
- W2035708390 hasConcept C125287762 @default.
- W2035708390 hasConcept C142724271 @default.
- W2035708390 hasConcept C159047783 @default.
- W2035708390 hasConcept C159985019 @default.
- W2035708390 hasConcept C185592680 @default.
- W2035708390 hasConcept C192562407 @default.
- W2035708390 hasConcept C204787440 @default.
- W2035708390 hasConcept C2522874641 @default.
- W2035708390 hasConcept C27081682 @default.
- W2035708390 hasConcept C2776175608 @default.
- W2035708390 hasConcept C2777056448 @default.
- W2035708390 hasConcept C2777869810 @default.
- W2035708390 hasConcept C2780593183 @default.
- W2035708390 hasConcept C3018890749 @default.
- W2035708390 hasConcept C43617362 @default.
- W2035708390 hasConcept C71924100 @default.
- W2035708390 hasConcept C87813604 @default.
- W2035708390 hasConcept C98274493 @default.
- W2035708390 hasConceptScore W2035708390C112705442 @default.
- W2035708390 hasConceptScore W2035708390C125287762 @default.
- W2035708390 hasConceptScore W2035708390C142724271 @default.
- W2035708390 hasConceptScore W2035708390C159047783 @default.
- W2035708390 hasConceptScore W2035708390C159985019 @default.
- W2035708390 hasConceptScore W2035708390C185592680 @default.
- W2035708390 hasConceptScore W2035708390C192562407 @default.
- W2035708390 hasConceptScore W2035708390C204787440 @default.
- W2035708390 hasConceptScore W2035708390C2522874641 @default.
- W2035708390 hasConceptScore W2035708390C27081682 @default.
- W2035708390 hasConceptScore W2035708390C2776175608 @default.
- W2035708390 hasConceptScore W2035708390C2777056448 @default.
- W2035708390 hasConceptScore W2035708390C2777869810 @default.
- W2035708390 hasConceptScore W2035708390C2780593183 @default.
- W2035708390 hasConceptScore W2035708390C3018890749 @default.
- W2035708390 hasConceptScore W2035708390C43617362 @default.
- W2035708390 hasConceptScore W2035708390C71924100 @default.
- W2035708390 hasConceptScore W2035708390C87813604 @default.
- W2035708390 hasConceptScore W2035708390C98274493 @default.
- W2035708390 hasIssue "10" @default.
- W2035708390 hasLocation W20357083901 @default.
- W2035708390 hasLocation W20357083902 @default.
- W2035708390 hasLocation W20357083903 @default.
- W2035708390 hasOpenAccess W2035708390 @default.
- W2035708390 hasPrimaryLocation W20357083901 @default.
- W2035708390 hasRelatedWork W1963842437 @default.
- W2035708390 hasRelatedWork W1984317973 @default.
- W2035708390 hasRelatedWork W2001333918 @default.
- W2035708390 hasRelatedWork W2071398502 @default.
- W2035708390 hasRelatedWork W2365953299 @default.
- W2035708390 hasRelatedWork W2373403320 @default.
- W2035708390 hasRelatedWork W2391021644 @default.
- W2035708390 hasRelatedWork W3142128585 @default.
- W2035708390 hasRelatedWork W2055653035 @default.
- W2035708390 hasRelatedWork W2187393073 @default.
- W2035708390 hasVolume "60" @default.
- W2035708390 isParatext "false" @default.
- W2035708390 isRetracted "false" @default.
- W2035708390 magId "2035708390" @default.
- W2035708390 workType "article" @default.