FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035710003> ?p ?o ?g. }

• W2035710003 endingPage "401" @default.
• W2035710003 startingPage "389" @default.
• W2035710003 abstract "Subcutaneous (s.c.) administration of bee venom into the plantar surface of one hind paw in rats has been found to produce an immediate single phase of persistent spontaneous nociceptive responses (continuously flinching, licking or lifting the injected paw) for 1–2 h accompanied by a 72–96 hour period of primary heat and mechanical hyperalgesia in the injection site and a spread of heat, but not mechanical, hyperalgesia in the non-injected hind paw (Chen et al., 1999b). To gain insight into the underlying mechanisms of the bee venom-induced hyperalgesia in particular, we further identified a heat, but not mechanical, hyperalgesia in an area (paw pad) distant from the injection site induced by s.c. injection of bee venom into the posterior leg 0.8–1.2 cm proximal to the heel measured by paw withdrawal reflex to radiant heat or von Frey monofilament stimuli in conscious rats. In the bee venom-treated hind limb, however, significant reduction in both thermal latency and mechanical threshold of withdrawal reflex was identified for a period of more than 96 h in the heel with a similar characteristic to the primary heat and mechanical hyperalgesia identified in the injection site previously. The time course of the heat hyperalgesia identified in the paw pad of the bee venom-treated side was shorter and lasted for less than 48 h, which was in parallel with the reduction in thermal latency of the withdrawal reflex identified in the non-injected hind paw. Moreover, pre- or post-treatment with a single dose of MK-801 (0.01 mg/kg, i.p.), a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, completely blocked the occurrence, and reversed the established process of the heat hyperalgesia identified in either the bee venom-treated or non-treated paw pads, while the same treatments with the drug did not produce any influence upon the development and maintaining of the heat and mechanical hyperalgesia identified in the heel of the injected hind limb. Taken together with our previous results following s.c. intraplantar bee venom injection, we conclude that: (1) in addition to the well-identified primary heat and mechanical hyperalgesia in the injection site and its adjacent area, s.c. bee venom is also able to produce a secondary heat hyperalgesia in a region distant from the injection site which has a similar characteristic to the contralateral heat hyperalgesia; (2) NMDA receptors are involved in either development or maintenance of the secondary and the contralateral heat hyperalgesia, but without any role in those processes of the primary heat and mechanical hyperalgesia; (3) the secondary heat hyperalgesia seen in the injected hind limb is likely to share the same neural mechanisms with that identified in the non-injected side via co-activation of NMDA receptors." @default.
• W2035710003 created "2016-06-24" @default.
• W2035710003 creator A5070578002 @default.
• W2035710003 creator A5082857859 @default.
• W2035710003 date "2000-12-01" @default.
• W2035710003 modified "2023-09-27" @default.
• W2035710003 title "Secondary heat, but not mechanical, hyperalgesia induced by subcutaneous injection of bee venom in the conscious rat: effect of systemic MK-801, a non-competitive NMDA receptor antagonist" @default.
• W2035710003 cites W166595509 @default.
• W2035710003 cites W1834905825 @default.
• W2035710003 cites W1918669680 @default.
• W2035710003 cites W1970269341 @default.
• W2035710003 cites W1972944322 @default.
• W2035710003 cites W1982266887 @default.
• W2035710003 cites W1982939797 @default.
• W2035710003 cites W1983585503 @default.
• W2035710003 cites W1989804049 @default.
• W2035710003 cites W1990149170 @default.
• W2035710003 cites W1993877941 @default.
• W2035710003 cites W1998088053 @default.
• W2035710003 cites W1999483556 @default.
• W2035710003 cites W2004869334 @default.
• W2035710003 cites W2005426034 @default.
• W2035710003 cites W2006399227 @default.
• W2035710003 cites W2006983639 @default.
• W2035710003 cites W2007415551 @default.
• W2035710003 cites W2014007136 @default.
• W2035710003 cites W2014284808 @default.
• W2035710003 cites W2019674556 @default.
• W2035710003 cites W2021871301 @default.
• W2035710003 cites W2046026171 @default.
• W2035710003 cites W2046761549 @default.
• W2035710003 cites W2053864414 @default.
• W2035710003 cites W2058548911 @default.
• W2035710003 cites W2060370855 @default.
• W2035710003 cites W2061132063 @default.
• W2035710003 cites W2069035861 @default.
• W2035710003 cites W2071488336 @default.
• W2035710003 cites W2074377976 @default.
• W2035710003 cites W2077370620 @default.
• W2035710003 cites W2079226821 @default.
• W2035710003 cites W2080076872 @default.
• W2035710003 cites W2083025317 @default.
• W2035710003 cites W2084429447 @default.
• W2035710003 cites W2087454739 @default.
• W2035710003 cites W2090730917 @default.
• W2035710003 cites W2091811815 @default.
• W2035710003 cites W2092888659 @default.
• W2035710003 cites W2102396911 @default.
• W2035710003 cites W2103552254 @default.
• W2035710003 cites W2140420818 @default.
• W2035710003 cites W2145340623 @default.
• W2035710003 cites W2148957287 @default.
• W2035710003 cites W2156887209 @default.
• W2035710003 cites W2159823414 @default.
• W2035710003 cites W2169449669 @default.
• W2035710003 cites W4231837856 @default.
• W2035710003 cites W4232614478 @default.
• W2035710003 doi "https://doi.org/10.1053/eujp.2000.0197" @default.
• W2035710003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11124011" @default.
• W2035710003 hasPublicationYear "2000" @default.
• W2035710003 type Work @default.
• W2035710003 sameAs 2035710003 @default.
• W2035710003 citedByCount "61" @default.
• W2035710003 countsByYear W20357100032012 @default.
• W2035710003 countsByYear W20357100032013 @default.
• W2035710003 countsByYear W20357100032014 @default.
• W2035710003 countsByYear W20357100032015 @default.
• W2035710003 countsByYear W20357100032016 @default.
• W2035710003 countsByYear W20357100032017 @default.
• W2035710003 countsByYear W20357100032018 @default.
• W2035710003 countsByYear W20357100032019 @default.
• W2035710003 crossrefType "journal-article" @default.
• W2035710003 hasAuthorship W2035710003A5070578002 @default.
• W2035710003 hasAuthorship W2035710003A5082857859 @default.
• W2035710003 hasConcept C126322002 @default.
• W2035710003 hasConcept C15490471 @default.
• W2035710003 hasConcept C170493617 @default.
• W2035710003 hasConcept C185592680 @default.
• W2035710003 hasConcept C195512701 @default.
• W2035710003 hasConcept C2779245659 @default.
• W2035710003 hasConcept C2780723003 @default.
• W2035710003 hasConcept C42219234 @default.
• W2035710003 hasConcept C51738704 @default.
• W2035710003 hasConcept C71924100 @default.
• W2035710003 hasConcept C83974742 @default.
• W2035710003 hasConcept C98274493 @default.
• W2035710003 hasConceptScore W2035710003C126322002 @default.
• W2035710003 hasConceptScore W2035710003C15490471 @default.
• W2035710003 hasConceptScore W2035710003C170493617 @default.
• W2035710003 hasConceptScore W2035710003C185592680 @default.
• W2035710003 hasConceptScore W2035710003C195512701 @default.
• W2035710003 hasConceptScore W2035710003C2779245659 @default.
• W2035710003 hasConceptScore W2035710003C2780723003 @default.
• W2035710003 hasConceptScore W2035710003C42219234 @default.
• W2035710003 hasConceptScore W2035710003C51738704 @default.
• W2035710003 hasConceptScore W2035710003C71924100 @default.
• W2035710003 hasConceptScore W2035710003C83974742 @default.
• W2035710003 hasConceptScore W2035710003C98274493 @default.

• next