Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035711242> ?p ?o ?g. }
- W2035711242 endingPage "147" @default.
- W2035711242 startingPage "135" @default.
- W2035711242 abstract "UVA radiation generates a significant oxidative stress in skin cells which is further enhanced by the release of the pro-oxidant catalysts iron and heme, and exacerbated by UVA-mediated destruction of cellular reducing equivalents and the antioxidant enzyme catalase. An important consequence of this altered redox state is the generation of oxidized membrane components in the form of 4-hydroxynonenal, ceramides and oxidized phospholipids, all of which are potent signalling molecules which lead to modulation of the expression of many genes. Transcription factors (such as nuclear factor kappa-light-chain-enhancer of activated B cells) and several genes (e.g. interleukins, intercellular adhesion molecule and 1, hemeoxygenase 1) involved in the inflammatory response are dramatically modified by UVA. Levels of both antioxidant and pro-oxidant proteins, including manganese-dependent superoxide dismutase, glutathione peroxidase, hemeoxygenase 1, NADPH oxidase, ferritin, and methionine-S-sulfoxidereductase, are increased by UVA treatment and following moderate dose levels these will contribute to either the restoration or a further perturbation of redox homeostasis. Finally, UVA induces a whole set of matrix metalloproteinases and proteases, primarily in cells of dermal origin, which can contribute to the long-term consequences of UVA exposure of skin." @default.
- W2035711242 created "2016-06-24" @default.
- W2035711242 creator A5048867446 @default.
- W2035711242 date "2012-11-01" @default.
- W2035711242 modified "2023-10-02" @default.
- W2035711242 title "Modulation of gene expression by the oxidative stress generated in human skin cells by UVA radiation and the restoration of redox homeostasis" @default.
- W2035711242 cites W1559274360 @default.
- W2035711242 cites W1559821198 @default.
- W2035711242 cites W1576400113 @default.
- W2035711242 cites W1585805915 @default.
- W2035711242 cites W1655162787 @default.
- W2035711242 cites W1826137220 @default.
- W2035711242 cites W1827851334 @default.
- W2035711242 cites W1928541796 @default.
- W2035711242 cites W1964053201 @default.
- W2035711242 cites W1965633143 @default.
- W2035711242 cites W1966172304 @default.
- W2035711242 cites W1966983858 @default.
- W2035711242 cites W1969851621 @default.
- W2035711242 cites W1970121396 @default.
- W2035711242 cites W1971007638 @default.
- W2035711242 cites W1971130793 @default.
- W2035711242 cites W1971299434 @default.
- W2035711242 cites W1972073402 @default.
- W2035711242 cites W1972738625 @default.
- W2035711242 cites W1972764616 @default.
- W2035711242 cites W1976855318 @default.
- W2035711242 cites W1977192648 @default.
- W2035711242 cites W1977902787 @default.
- W2035711242 cites W1978058355 @default.
- W2035711242 cites W1978863709 @default.
- W2035711242 cites W1979501908 @default.
- W2035711242 cites W1981397830 @default.
- W2035711242 cites W1983644941 @default.
- W2035711242 cites W1986450799 @default.
- W2035711242 cites W1990520418 @default.
- W2035711242 cites W1991255877 @default.
- W2035711242 cites W1991376505 @default.
- W2035711242 cites W1992134327 @default.
- W2035711242 cites W1992589932 @default.
- W2035711242 cites W1993596487 @default.
- W2035711242 cites W1993838345 @default.
- W2035711242 cites W1999997271 @default.
- W2035711242 cites W2000001611 @default.
- W2035711242 cites W2002217214 @default.
- W2035711242 cites W2002928259 @default.
- W2035711242 cites W2003962192 @default.
- W2035711242 cites W2004869179 @default.
- W2035711242 cites W2005075136 @default.
- W2035711242 cites W2005846423 @default.
- W2035711242 cites W2010353908 @default.
- W2035711242 cites W2010378990 @default.
- W2035711242 cites W2011245371 @default.
- W2035711242 cites W2011493869 @default.
- W2035711242 cites W2011504208 @default.
- W2035711242 cites W2011745532 @default.
- W2035711242 cites W2012022914 @default.
- W2035711242 cites W2012189423 @default.
- W2035711242 cites W2017955353 @default.
- W2035711242 cites W2018129199 @default.
- W2035711242 cites W2022279037 @default.
- W2035711242 cites W2022320534 @default.
- W2035711242 cites W2022560636 @default.
- W2035711242 cites W2022604404 @default.
- W2035711242 cites W2023579489 @default.
- W2035711242 cites W2023587041 @default.
- W2035711242 cites W2024873389 @default.
- W2035711242 cites W2025101541 @default.
- W2035711242 cites W2027008375 @default.
- W2035711242 cites W2027707520 @default.
- W2035711242 cites W2032100386 @default.
- W2035711242 cites W2034397996 @default.
- W2035711242 cites W2036737310 @default.
- W2035711242 cites W2038634209 @default.
- W2035711242 cites W2039198900 @default.
- W2035711242 cites W2039284979 @default.
- W2035711242 cites W2041553103 @default.
- W2035711242 cites W2042075199 @default.
- W2035711242 cites W2044485209 @default.
- W2035711242 cites W2045233234 @default.
- W2035711242 cites W2049387238 @default.
- W2035711242 cites W2050517433 @default.
- W2035711242 cites W2053467638 @default.
- W2035711242 cites W2053764541 @default.
- W2035711242 cites W2058927956 @default.
- W2035711242 cites W2060050010 @default.
- W2035711242 cites W2061587634 @default.
- W2035711242 cites W2062524418 @default.
- W2035711242 cites W2062579488 @default.
- W2035711242 cites W2066589243 @default.
- W2035711242 cites W2066745245 @default.
- W2035711242 cites W2067022644 @default.
- W2035711242 cites W2067371928 @default.
- W2035711242 cites W2069235452 @default.
- W2035711242 cites W2070549611 @default.
- W2035711242 cites W2070693959 @default.
- W2035711242 cites W2071469250 @default.
- W2035711242 cites W2071656662 @default.