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- W2035711557 abstract "Background Previous studies have suggested an influence of HLA molecules on the regulation of the anti Mycobacterium leprae immune response. Methods DNA typing of HLA-DRB1 alleles in 71 leprosy patients and 81 healthy controls was performed. Genomic DNA was extracted from peripheral blood and used as a template to amplify the polymorphic second exon of the HLA-DRBl by the ploymerase chain reaction (PCR). PCR products were hybridized separately with sequence-specific oligonucleotides. Results DRB1*1401 and DRB1*1406 alleles were significantly more prevalent in leprosy patients, whereas a decreased frequency of DRB1*0808 and DRB1*1103 alleles was found, by comparison with the group control. Conclusions The HLA-DRB1 alleles could act alone or in combination with other genes to confer differential susceptibility and also protection to leprosy disease in endemic areas of the American continent." @default.
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- W2035711557 date "2008-01-01" @default.
- W2035711557 modified "2023-09-26" @default.
- W2035711557 title "Association of leprosy with HLA-DRB1 in an Argentinean population" @default.
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- W2035711557 doi "https://doi.org/10.1258/acb.2007.007156" @default.
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