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• W2035718283 abstract "XNP/ATRX , a causative gene of X‐linked α‐thalassemia/mental retardation syndrome, encodes an SNF2 family ATPase/helicase protein. To better understand the role of XNP/ATRX in development, we isolated and characterized a Drosophila XNP/ATRX homolog, dXNP, which contains highly conserved SNF2 and helicase domains. Ectopically expressed dXNP induced strong apoptosis in the developing eye and wing, but did not affect cell cycle progression or the expression of wingless and engrailed , essential regulators of development. The dXNP ‐induced apoptosis was strongly suppressed by DJNKK / hemipterous mutation, and dXNP increased JNK activity. Taken together, these results suggest that dXNP regulates apoptosis via JNK activation." @default.
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• W2035718283 date "2007-05-11" @default.
• W2035718283 modified "2023-10-14" @default.
• W2035718283 title "dXNP, a <i>Drosophila</i> homolog of XNP/ATRX, induces apoptosis via Jun‐N‐terminal kinase activation" @default.
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• W2035718283 doi "https://doi.org/10.1016/j.febslet.2007.05.005" @default.
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