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• W2035721844 abstract "Substantial progress has been made in determining developmental relationships between lymphocyte precursors and those corresponding to other blood cell lineages. Indeed, exploitation of RAG1/GFP knock-in mice has recently made it possible to chart the entire sequence of lymphocyte differentiation events in adult bone marrow and thymus. However, the differentiation pathways proposed for fetal life are very different from this model. We review many examples where the results of gene targeting experiments are substantially dependent on developmental age. In mice, adult patterns of gene expression and corresponding properties of lymphocyte precursors are not fully established until several weeks after birth, and the same might be true for humans. Furthermore, examples are cited where fetal hematopoietic cells did not efficiently acquire those properties when transplanted to an adult environment. There are several important implications of these findings. Cognizance of developmental age-related changes might resolve apparent conflicts in the literature. Hematopoietic stem cells and their lymphoid lineage progeny appear in waves, and a direct connection is yet to be established between fetal stem cells and ones that sustain adult blood cell formation. There is the possibility that adult stem cells derive from founders with an unknown origin." @default.
• W2035721844 created "2016-06-24" @default.
• W2035721844 creator A5012983576 @default.
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• W2035721844 date "2002-09-01" @default.
• W2035721844 modified "2023-09-29" @default.
• W2035721844 title "Nature or nurture? Steady-state lymphocyte formation in adults does not recapitulate ontogeny" @default.
• W2035721844 cites W1481419339 @default.
• W2035721844 cites W1482479272 @default.
• W2035721844 cites W1491349678 @default.
• W2035721844 cites W1500113424 @default.
• W2035721844 cites W1503212217 @default.
• W2035721844 cites W1518159864 @default.
• W2035721844 cites W1533296902 @default.
• W2035721844 cites W1534222607 @default.
• W2035721844 cites W1559018455 @default.
• W2035721844 cites W1560718557 @default.
• W2035721844 cites W1575201799 @default.
• W2035721844 cites W1585647397 @default.
• W2035721844 cites W1590467919 @default.
• W2035721844 cites W1595572144 @default.
• W2035721844 cites W1603686862 @default.
• W2035721844 cites W1897184448 @default.
• W2035721844 cites W1951080503 @default.
• W2035721844 cites W1972518526 @default.
• W2035721844 cites W1973035870 @default.
• W2035721844 cites W1975479114 @default.
• W2035721844 cites W1980212327 @default.
• W2035721844 cites W1981817625 @default.
• W2035721844 cites W1986263057 @default.
• W2035721844 cites W1987320897 @default.
• W2035721844 cites W1988496527 @default.
• W2035721844 cites W1989645452 @default.
• W2035721844 cites W1993398229 @default.
• W2035721844 cites W1995286997 @default.
• W2035721844 cites W1995946399 @default.
• W2035721844 cites W1996596321 @default.
• W2035721844 cites W1997056099 @default.
• W2035721844 cites W1999038480 @default.
• W2035721844 cites W2008661167 @default.
• W2035721844 cites W2013989617 @default.
• W2035721844 cites W2014257373 @default.
• W2035721844 cites W2014752369 @default.
• W2035721844 cites W2024562705 @default.
• W2035721844 cites W2025773873 @default.
• W2035721844 cites W2027286104 @default.
• W2035721844 cites W2036340292 @default.
• W2035721844 cites W2037931509 @default.
• W2035721844 cites W2044677032 @default.
• W2035721844 cites W2051687429 @default.
• W2035721844 cites W2056111737 @default.
• W2035721844 cites W2058781233 @default.
• W2035721844 cites W2067131315 @default.
• W2035721844 cites W2068660936 @default.
• W2035721844 cites W2081617617 @default.
• W2035721844 cites W2081995411 @default.
• W2035721844 cites W2090890518 @default.
• W2035721844 cites W2093835397 @default.
• W2035721844 cites W2093931465 @default.
• W2035721844 cites W2100378064 @default.
• W2035721844 cites W2100590134 @default.
• W2035721844 cites W2102067914 @default.
• W2035721844 cites W2106794474 @default.
• W2035721844 cites W2117455815 @default.
• W2035721844 cites W2121522599 @default.
• W2035721844 cites W2122879998 @default.
• W2035721844 cites W2129746041 @default.
• W2035721844 cites W2138672615 @default.
• W2035721844 cites W2138758015 @default.
• W2035721844 cites W2144579631 @default.
• W2035721844 cites W2146513661 @default.
• W2035721844 cites W2150409084 @default.
• W2035721844 cites W2152414109 @default.
• W2035721844 cites W2163127671 @default.
• W2035721844 cites W2163922871 @default.
• W2035721844 cites W2165564045 @default.
• W2035721844 cites W2169868745 @default.
• W2035721844 cites W2170963974 @default.
• W2035721844 cites W2224375530 @default.
• W2035721844 cites W2320870204 @default.
• W2035721844 cites W2343678111 @default.
• W2035721844 cites W2405722052 @default.
• W2035721844 cites W4210957777 @default.
• W2035721844 cites W4313331448 @default.
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• W2035721844 doi "https://doi.org/10.1034/j.1600-065x.2002.18710.x" @default.
• W2035721844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12366687" @default.
• W2035721844 hasPublicationYear "2002" @default.
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