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• W2035726492 abstract "Although the response of macrophages to polyethylene debris has been widely studied, it has never been compared with the cellular response to ceramic debris. Our aim was to investigate the cytotoxicity of ceramic particles (Al 2 O 3 and ZrO 2 ) and to analyse their ability to stimulate the release of inflammatory mediators compared with that of high-density polyethylene particles (HDP). We analysed the effects of particle size, concentration and composition using an in vitro model. The J774 mouse macrophage cell line was exposed to commercial particles in the phagocytosable range (up to 4.5 μm). Al 2 O 3 was compared with ZrO 2 at 0.6 μm and with HDP at 4.5 μm. Cytotoxicity tests were performed using flow cytometry and macrophage cytokine release was measured by ELISA. Cell mortality increased with the size and concentration of Al 2 O 3 particles. When comparing Al 2 O 3 and ZrO 2 at 0.6 μm, we did not detect any significant difference at the concentrations analysed (up to 2500 particles per macrophage), and mortality remained very low (less than 10%). Release of TNF-α also increased with the size and concentration of Al 2 O 3 particles, reaching 195% of control (165 pg/ml v 84 pg/ml) at 2.4 μm and 350 particles per cell (p < 0.05). Release of TNF-α was higher with HDP than with Al 2 O 3 particles at 4.5 μm. However, we did not detect any significant difference in the release of TNF-α between Al 2 O 3 and ZrO 2 at 0.6 μm (p > 0.05). We saw no evidence of release of interleukin-1α or interleukin-1ß after exposure to ceramic or HDP particles." @default.
• W2035726492 created "2016-06-24" @default.
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• W2035726492 date "1999-05-01" @default.
• W2035726492 modified "2023-10-16" @default.
• W2035726492 title "Cytotoxicity and macrophage cytokine release induced by ceramic and polyethylene particles in vitro" @default.
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• W2035726492 doi "https://doi.org/10.1302/0301-620x.81b3.0810516" @default.
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