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- W2035726797 abstract "Peripheral blood lymphocytes from 44 Stage I endometrial carcinoma patients were tested for their natural killer (NK) cell activity against K562 cell line targets, for mitogenic (PHA) responsiveness, and for surface markers. The patients belonged to a clinical trial where group A (control) received surgery plus intravaginal cathetron and group B in addition got adjuvant treatment with hydroxyprogesterone caproate (1000 mg im every 2 weeks) for 1 year postsurgery. During progestogen treatment lymphocytes from group B patients showed an elevated NK activity and were enriched for cells bearing receptors for the Fc-part of immunoglobulin G. These effects were no longer seen 3–6 months after progestogen therapy was stopped. No T-lymphocyte enrichment was observed, but on a per cell basis cells from group B patients responded better to PHA stimulation than did cells from group A, and continued to do so 3–6 months after the treatment was discontinued. Hydroxyprogesterone caproate thus may have some in vivo immunopotentiating effects on both NK cells and T cells." @default.
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- W2035726797 date "1982-12-01" @default.
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- W2035726797 title "Adjuvant hydroxyprogesterone caproate in stage I endometrial carcinoma: Changes in numbers and reactivities of some blood lymphocyte subpopulations" @default.
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- W2035726797 doi "https://doi.org/10.1016/0090-8258(82)90110-x" @default.
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