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- W2035727234 abstract "The present experiments were performed to investigate the effects of the selective μ opioid receptor antagonist, ß-funaltrexamine (ß-FNA), on the physical dependence liability of butorphanol (a mixed agonist/antagonist opioid analgesic). Butorphanol (26 nmol/μl/h) was continuously infused via osmotic minipumps into the lateral cerebral ventricle of male Sprague-Dawley rats for 72 h. ß-FNA (12, 24, and 48 nmol/5 μl/rat) was administered ICV 3 h prior to and 48 h after initiation of the butorphanol infusion. Treatment with ß-FNA significantly diminished naloxone-induced escape behavior, hypothermia, and loss of body weight in a dose-dependent manner, while naloxone-induced teeth-chattering, forepaw tremors, and urination were also reduced, but in a dose-independent manner. These results suggest that the μ opioid receptor is partially involved in the development of physical dependence upon butorphanol." @default.
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- W2035727234 date "1992-05-01" @default.
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- W2035727234 title "Effects of ß-funaltrexamine on butorphanol dependence" @default.
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- W2035727234 doi "https://doi.org/10.1016/0091-3057(92)90441-h" @default.
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