Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035735908> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2035735908 endingPage "A6" @default.
- W2035735908 startingPage "A5.3" @default.
- W2035735908 abstract "<h3>Backround</h3> Dendritic cells (DCs) play an important role in bridging the innate and the adaptive immune response by serving as antigen presenting cells and are therefore implicated in the initiation of chronic autoimmune diseases, including rheumatoid arthritis. Using the K/BxN serum transfer arthritis, a model of human rheumatoid arthritis, which depends only on the innate immune system, allowed us to investigate the innate role role of dendritic cells in inflammatory arthritis. <h3>Methods</h3> KBxN serum transfer arthritis was induced in CD11c-diphteria toxin receptor (DTR) transgenic mice, which express the human diphtheria-toxin receptor under the CD11c promoter. This allows for specific depletion of CD11c+ cells by administration of diphtheria toxin (DT). DT or PBS were given on day -1, 3, 6 and 9 and the severity of arthritis was determined clinically and histologically. In addition, serum transfer arthritis was induced in wild type animals who also received DT. <h3>Results</h3> Efficient depletion of DCs from the spleen after injection of DT was confirmed by flow cytometry and histological analysis. Clinical scores of arthritis showed that CD11c-DTR transgenic mice had significantly reduced paw swelling and loss of grip strength compared to PBS treated animals. In contrast, wild type animals receiving DT showed identical clinical signs of arthritis as PBS treated animals, excluding unspecific effects of DT in mice. Histological analysis found that CD11c-DTR transgenic mice that had received DT displayed decreased synovial inflammation and a trend towards reduced local bone destruction. <h3>Conclusions</h3> These data show that dendritic cells are involved in innate reactions leading to inflammatory arthritis and suggest that dendritic cells could be an important target for rheumatoid arthritis therapy." @default.
- W2035735908 created "2016-06-24" @default.
- W2035735908 creator A5013093033 @default.
- W2035735908 creator A5013172612 @default.
- W2035735908 creator A5035556723 @default.
- W2035735908 creator A5042080557 @default.
- W2035735908 creator A5063691242 @default.
- W2035735908 creator A5067661704 @default.
- W2035735908 creator A5082389369 @default.
- W2035735908 date "2013-02-25" @default.
- W2035735908 modified "2023-09-27" @default.
- W2035735908 title "A2.5 CD11c+ Dendritic Cells Play an Important Proinflammatory Role in Inflammatory Arthritis" @default.
- W2035735908 doi "https://doi.org/10.1136/annrheumdis-2013-203215.5" @default.
- W2035735908 hasPublicationYear "2013" @default.
- W2035735908 type Work @default.
- W2035735908 sameAs 2035735908 @default.
- W2035735908 citedByCount "0" @default.
- W2035735908 crossrefType "journal-article" @default.
- W2035735908 hasAuthorship W2035735908A5013093033 @default.
- W2035735908 hasAuthorship W2035735908A5013172612 @default.
- W2035735908 hasAuthorship W2035735908A5035556723 @default.
- W2035735908 hasAuthorship W2035735908A5042080557 @default.
- W2035735908 hasAuthorship W2035735908A5063691242 @default.
- W2035735908 hasAuthorship W2035735908A5067661704 @default.
- W2035735908 hasAuthorship W2035735908A5082389369 @default.
- W2035735908 hasBestOaLocation W20357359081 @default.
- W2035735908 hasConcept C104317684 @default.
- W2035735908 hasConcept C127716648 @default.
- W2035735908 hasConcept C136449434 @default.
- W2035735908 hasConcept C164027704 @default.
- W2035735908 hasConcept C193419808 @default.
- W2035735908 hasConcept C203014093 @default.
- W2035735908 hasConcept C2776914184 @default.
- W2035735908 hasConcept C2777077863 @default.
- W2035735908 hasConcept C2777367657 @default.
- W2035735908 hasConcept C2777575956 @default.
- W2035735908 hasConcept C2778170410 @default.
- W2035735908 hasConcept C2779919695 @default.
- W2035735908 hasConcept C33057221 @default.
- W2035735908 hasConcept C55493867 @default.
- W2035735908 hasConcept C71924100 @default.
- W2035735908 hasConcept C86803240 @default.
- W2035735908 hasConcept C8891405 @default.
- W2035735908 hasConceptScore W2035735908C104317684 @default.
- W2035735908 hasConceptScore W2035735908C127716648 @default.
- W2035735908 hasConceptScore W2035735908C136449434 @default.
- W2035735908 hasConceptScore W2035735908C164027704 @default.
- W2035735908 hasConceptScore W2035735908C193419808 @default.
- W2035735908 hasConceptScore W2035735908C203014093 @default.
- W2035735908 hasConceptScore W2035735908C2776914184 @default.
- W2035735908 hasConceptScore W2035735908C2777077863 @default.
- W2035735908 hasConceptScore W2035735908C2777367657 @default.
- W2035735908 hasConceptScore W2035735908C2777575956 @default.
- W2035735908 hasConceptScore W2035735908C2778170410 @default.
- W2035735908 hasConceptScore W2035735908C2779919695 @default.
- W2035735908 hasConceptScore W2035735908C33057221 @default.
- W2035735908 hasConceptScore W2035735908C55493867 @default.
- W2035735908 hasConceptScore W2035735908C71924100 @default.
- W2035735908 hasConceptScore W2035735908C86803240 @default.
- W2035735908 hasConceptScore W2035735908C8891405 @default.
- W2035735908 hasIssue "Suppl 1" @default.
- W2035735908 hasLocation W20357359081 @default.
- W2035735908 hasOpenAccess W2035735908 @default.
- W2035735908 hasPrimaryLocation W20357359081 @default.
- W2035735908 hasRelatedWork W1556307916 @default.
- W2035735908 hasRelatedWork W2010826498 @default.
- W2035735908 hasRelatedWork W2103515427 @default.
- W2035735908 hasRelatedWork W2132317181 @default.
- W2035735908 hasRelatedWork W2133765154 @default.
- W2035735908 hasRelatedWork W2141330728 @default.
- W2035735908 hasRelatedWork W2946615038 @default.
- W2035735908 hasRelatedWork W3214245850 @default.
- W2035735908 hasRelatedWork W4206425682 @default.
- W2035735908 hasRelatedWork W4315797293 @default.
- W2035735908 hasVolume "72" @default.
- W2035735908 isParatext "false" @default.
- W2035735908 isRetracted "false" @default.
- W2035735908 magId "2035735908" @default.
- W2035735908 workType "article" @default.