Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035736475> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2035736475 endingPage "363" @default.
- W2035736475 startingPage "353" @default.
- W2035736475 abstract "HLAMatchmaker is a computer algorithm that assesses human leukocyte antigen (HLA) compatibility at the structural level by intralocus and interlocus comparisons of polymorphic amino acid triplets in antibody-accessible sequences of HLA class I molecules. This program permits the identification of mismatched HLA antigens that share all of their polymorphic triplets with the patient’s HLA antigens and, therefore, could be considered fully compatible. The validity of this algorithm has been verified by analyzing the antibody specificity patterns of 127 well-characterized sera (panel reactive antibody [PRA] > 80%) that had been screened by direct complement-dependent and/or anti-human globulin augmented lymphocytotoxicity testing with large HLA-typed cell panels. A 2×2 table-based Chi-square analysis program was applied to determine positive and negative correlations between serum reactivity and the presence HLA triplets assigned from the HLA types in the cell panel. The results indicate that high PRA patients do not produce antibodies to shared triplets on mismatched HLA antigens. Moreover, this serum analysis has permitted the identification of triplets with different degrees of immunogenicity as indicated by the frequencies of positive and negative correlations of serum reactivity with the HLA-typed cell panel. Mismatching for triplets with low immunogenicity provides further opportunities for identifying donors with acceptable HLA mismatches for highly sensitized patients." @default.
- W2035736475 created "2016-06-24" @default.
- W2035736475 creator A5079977674 @default.
- W2035736475 creator A5090312506 @default.
- W2035736475 date "2002-05-01" @default.
- W2035736475 modified "2023-10-16" @default.
- W2035736475 title "HLAMatchmaker: a molecularly based algorithm for histocompatibility determination. II. Verification of the algorithm and determination of the relative immunogenicity of amino acid triplet-defined epitopes" @default.
- W2035736475 cites W153015601 @default.
- W2035736475 cites W1966009720 @default.
- W2035736475 cites W1990976905 @default.
- W2035736475 cites W1995066505 @default.
- W2035736475 cites W2024691768 @default.
- W2035736475 cites W2046999407 @default.
- W2035736475 cites W2047028783 @default.
- W2035736475 cites W2053215379 @default.
- W2035736475 cites W2099028937 @default.
- W2035736475 cites W2113530505 @default.
- W2035736475 cites W2133247121 @default.
- W2035736475 cites W2195861155 @default.
- W2035736475 cites W2740745106 @default.
- W2035736475 doi "https://doi.org/10.1016/s0198-8859(02)00381-6" @default.
- W2035736475 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11975979" @default.
- W2035736475 hasPublicationYear "2002" @default.
- W2035736475 type Work @default.
- W2035736475 sameAs 2035736475 @default.
- W2035736475 citedByCount "91" @default.
- W2035736475 countsByYear W20357364752012 @default.
- W2035736475 countsByYear W20357364752014 @default.
- W2035736475 countsByYear W20357364752015 @default.
- W2035736475 countsByYear W20357364752016 @default.
- W2035736475 countsByYear W20357364752017 @default.
- W2035736475 countsByYear W20357364752018 @default.
- W2035736475 countsByYear W20357364752019 @default.
- W2035736475 countsByYear W20357364752020 @default.
- W2035736475 countsByYear W20357364752021 @default.
- W2035736475 countsByYear W20357364752022 @default.
- W2035736475 countsByYear W20357364752023 @default.
- W2035736475 crossrefType "journal-article" @default.
- W2035736475 hasAuthorship W2035736475A5079977674 @default.
- W2035736475 hasAuthorship W2035736475A5090312506 @default.
- W2035736475 hasConcept C11413529 @default.
- W2035736475 hasConcept C147483822 @default.
- W2035736475 hasConcept C159654299 @default.
- W2035736475 hasConcept C188280979 @default.
- W2035736475 hasConcept C195616568 @default.
- W2035736475 hasConcept C202965653 @default.
- W2035736475 hasConcept C203014093 @default.
- W2035736475 hasConcept C207936829 @default.
- W2035736475 hasConcept C2780868878 @default.
- W2035736475 hasConcept C41008148 @default.
- W2035736475 hasConcept C70721500 @default.
- W2035736475 hasConcept C86803240 @default.
- W2035736475 hasConceptScore W2035736475C11413529 @default.
- W2035736475 hasConceptScore W2035736475C147483822 @default.
- W2035736475 hasConceptScore W2035736475C159654299 @default.
- W2035736475 hasConceptScore W2035736475C188280979 @default.
- W2035736475 hasConceptScore W2035736475C195616568 @default.
- W2035736475 hasConceptScore W2035736475C202965653 @default.
- W2035736475 hasConceptScore W2035736475C203014093 @default.
- W2035736475 hasConceptScore W2035736475C207936829 @default.
- W2035736475 hasConceptScore W2035736475C2780868878 @default.
- W2035736475 hasConceptScore W2035736475C41008148 @default.
- W2035736475 hasConceptScore W2035736475C70721500 @default.
- W2035736475 hasConceptScore W2035736475C86803240 @default.
- W2035736475 hasIssue "5" @default.
- W2035736475 hasLocation W20357364751 @default.
- W2035736475 hasLocation W20357364752 @default.
- W2035736475 hasOpenAccess W2035736475 @default.
- W2035736475 hasPrimaryLocation W20357364751 @default.
- W2035736475 hasRelatedWork W1966634667 @default.
- W2035736475 hasRelatedWork W1990373061 @default.
- W2035736475 hasRelatedWork W2019183242 @default.
- W2035736475 hasRelatedWork W2021935957 @default.
- W2035736475 hasRelatedWork W2022175694 @default.
- W2035736475 hasRelatedWork W203802859 @default.
- W2035736475 hasRelatedWork W2271013594 @default.
- W2035736475 hasRelatedWork W2381567441 @default.
- W2035736475 hasRelatedWork W2405493166 @default.
- W2035736475 hasRelatedWork W4289975057 @default.
- W2035736475 hasVolume "63" @default.
- W2035736475 isParatext "false" @default.
- W2035736475 isRetracted "false" @default.
- W2035736475 magId "2035736475" @default.
- W2035736475 workType "article" @default.