Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035739969> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2035739969 endingPage "141" @default.
- W2035739969 startingPage "138" @default.
- W2035739969 abstract "Nonsteroidal anti-inflammatory drugs (NSAIDs), which are used widely to manage pain, are known to inhibit cyclooxygenase, but details of the mechanisms of NSAID action remain unclear. We investigated the ability of three NSAIDs (indomethacin, loxoprofen, and etodolac) to eliminate and inhibit free radicals. Superoxide scavenging activity of these NSAIDs was measured in vitro by electron spin resonance spectrometry using 5,5-dimethyl-1-pyrroline-1-oxide (DMPO) as a spin trap. Electron spin resonance demonstrated that formation of superoxide-DMPO spin adduct was completely inhibited by two nonselective cyclooxygenase inhibitors, indomethacin (3 mmol) and loxoprofen (3 mmol). The electron spin resonance study also demonstrated that the formation of superoxide-DMPO spin adduct was strongly inhibited by a selective cyclooxygenase-2 inhibitor, etodolac, in a concentration-dependent manner. These results indicate that NSAIDs, including indomethacin, loxoprofen, and etodolac, have direct superoxide scavenging activity." @default.
- W2035739969 created "2016-06-24" @default.
- W2035739969 creator A5022588790 @default.
- W2035739969 creator A5039061322 @default.
- W2035739969 creator A5046798526 @default.
- W2035739969 creator A5065941274 @default.
- W2035739969 creator A5084309021 @default.
- W2035739969 creator A5090984439 @default.
- W2035739969 date "2001-02-01" @default.
- W2035739969 modified "2023-10-16" @default.
- W2035739969 title "Direct Superoxide Scavenging Activity of Nonsteroidal Anti-inflammatory Drugs: Determination by Electron Spin Resonance Using the Spin Trap Method" @default.
- W2035739969 cites W1995413132 @default.
- W2035739969 cites W2019655208 @default.
- W2035739969 cites W2036746362 @default.
- W2035739969 cites W2046657873 @default.
- W2035739969 cites W2051583981 @default.
- W2035739969 cites W2074732906 @default.
- W2035739969 cites W2095797387 @default.
- W2035739969 cites W2149233326 @default.
- W2035739969 cites W4256507616 @default.
- W2035739969 doi "https://doi.org/10.1046/j.1526-4610.2001.111006138.x" @default.
- W2035739969 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11251697" @default.
- W2035739969 hasPublicationYear "2001" @default.
- W2035739969 type Work @default.
- W2035739969 sameAs 2035739969 @default.
- W2035739969 citedByCount "24" @default.
- W2035739969 countsByYear W20357399692012 @default.
- W2035739969 countsByYear W20357399692013 @default.
- W2035739969 countsByYear W20357399692016 @default.
- W2035739969 countsByYear W20357399692021 @default.
- W2035739969 countsByYear W20357399692023 @default.
- W2035739969 crossrefType "journal-article" @default.
- W2035739969 hasAuthorship W2035739969A5022588790 @default.
- W2035739969 hasAuthorship W2035739969A5039061322 @default.
- W2035739969 hasAuthorship W2035739969A5046798526 @default.
- W2035739969 hasAuthorship W2035739969A5065941274 @default.
- W2035739969 hasAuthorship W2035739969A5084309021 @default.
- W2035739969 hasAuthorship W2035739969A5090984439 @default.
- W2035739969 hasConcept C108204754 @default.
- W2035739969 hasConcept C121332964 @default.
- W2035739969 hasConcept C139066938 @default.
- W2035739969 hasConcept C178790620 @default.
- W2035739969 hasConcept C181199279 @default.
- W2035739969 hasConcept C185592680 @default.
- W2035739969 hasConcept C187961010 @default.
- W2035739969 hasConcept C2775838275 @default.
- W2035739969 hasConcept C2777807940 @default.
- W2035739969 hasConcept C2779689624 @default.
- W2035739969 hasConcept C2780795997 @default.
- W2035739969 hasConcept C46141821 @default.
- W2035739969 hasConcept C55493867 @default.
- W2035739969 hasConcept C71924100 @default.
- W2035739969 hasConcept C98274493 @default.
- W2035739969 hasConceptScore W2035739969C108204754 @default.
- W2035739969 hasConceptScore W2035739969C121332964 @default.
- W2035739969 hasConceptScore W2035739969C139066938 @default.
- W2035739969 hasConceptScore W2035739969C178790620 @default.
- W2035739969 hasConceptScore W2035739969C181199279 @default.
- W2035739969 hasConceptScore W2035739969C185592680 @default.
- W2035739969 hasConceptScore W2035739969C187961010 @default.
- W2035739969 hasConceptScore W2035739969C2775838275 @default.
- W2035739969 hasConceptScore W2035739969C2777807940 @default.
- W2035739969 hasConceptScore W2035739969C2779689624 @default.
- W2035739969 hasConceptScore W2035739969C2780795997 @default.
- W2035739969 hasConceptScore W2035739969C46141821 @default.
- W2035739969 hasConceptScore W2035739969C55493867 @default.
- W2035739969 hasConceptScore W2035739969C71924100 @default.
- W2035739969 hasConceptScore W2035739969C98274493 @default.
- W2035739969 hasIssue "2" @default.
- W2035739969 hasLocation W20357399691 @default.
- W2035739969 hasLocation W20357399692 @default.
- W2035739969 hasOpenAccess W2035739969 @default.
- W2035739969 hasPrimaryLocation W20357399691 @default.
- W2035739969 hasRelatedWork W166580006 @default.
- W2035739969 hasRelatedWork W1984965657 @default.
- W2035739969 hasRelatedWork W2012589012 @default.
- W2035739969 hasRelatedWork W2018126286 @default.
- W2035739969 hasRelatedWork W2023250274 @default.
- W2035739969 hasRelatedWork W2045311075 @default.
- W2035739969 hasRelatedWork W2050631778 @default.
- W2035739969 hasRelatedWork W2069676599 @default.
- W2035739969 hasRelatedWork W2077825449 @default.
- W2035739969 hasRelatedWork W2334419558 @default.
- W2035739969 hasVolume "41" @default.
- W2035739969 isParatext "false" @default.
- W2035739969 isRetracted "false" @default.
- W2035739969 magId "2035739969" @default.
- W2035739969 workType "article" @default.