FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035741632> ?p ?o ?g. }

• W2035741632 endingPage "1243" @default.
• W2035741632 startingPage "1235" @default.
• W2035741632 abstract "The purpose of this study was to evaluate the potential impact of concurrent weekly oral methotrexate administration on the pharmacokinetics of etanercept in patients with rheumatoid arthritis (RA) in a phase 3B trial. As part of a double‐blind randomized trial of 682 patients with rheumatoid arthritis who received etanercept (25 mg subcutaneously twice weekly), methotrexate (weekly oral dose, median weekly dose: 20 mg), or etanercept (25 mg subcutaneously twice weekly) plus methotrexate (weekly oral dose, median weekly dose: 20 mg), serum etanercept concentrations were measured in a subset of patients. Serum samples for 98 randomly selected patients (48 receiving etanercept‐alone treatment, 50 receiving etanercept plus methotrexate combination treatment) were analyzed to assess the pharmacokinetics of etanercept. A single blood sample was drawn from each patient at baseline and at the week 24 visit. Given the variable sampling time for patients in both groups, a population pharmacokinetic analysis using NONMEM was conducted for etanercept. A final covariate population pharmacokinetic model was constructed based on previously obtained etanercept data from both healthy subjects (n = 53) and patients with RA (n = 212) in 10 prior clinical trials. The predictive performance of the final model was assessed by both bootstrap and data‐splitting validation approaches. The final model was then used to estimate Bayesian pharmacokinetic parameters for the patients in both treatments in the current trial. The potential effect of the concurrent administration of methotrexate on the pharmacokinetics of etanercept was examined by comparing the clearance values between 2 treatments using statistical criteria. A population 2‐compartment model with first‐order elimination from the central compartment and with either zero‐order (intravenous administration) or first‐order (subcutaneous administration) input was selected based on the data from the prior 10 etanercept clinical studies. The following pharmacokinetic parameters (typical value ± standard error) were estimated: clearance (CL: 0.072 ± 0.005 L/h), volume of distribution in the central compartment (V c : 5.97 ± 0.45 L), volume of distribution in the peripheral compartment (V p : 2.05 ± 0.32 L), intercompartment clearance (Q: 0.0645 ± 0.0093 L/h), first‐order absorption rate constant (k a : 0.0282 ± 0.0039 1/h), and absolute bioavailability for subcutaneous administration (F: 0.626 ± 0.056). Interindividual variability of the pharmacokinetic parameters was quantified for CL (25.1%), V c (41.7%), k a (53.1%), and F (24.2%). Residual variability consisted of combined additive (11.4 ng/mL) and proportional error (49.9%). Both age (< 17 years) and body weight (< 60 kg) were found to be important covariates on CL. The results of both validation tests indicated the adequate predictive performance of the population model. Based on the bioequivalence criteria, the Bayesian‐estimated clearance for patients receiving etanercept alone (mean: 0.070 L/h) was comparable to that for patients receiving a combination of etanercept and methotrexate (mean = 0.066 L/h). The pharmacokinetics of etanercept were not altered by the concurrent administration of methotrexate in patients with rheumatoid arthritis. Thus, no etanercept dose adjustment is needed for patients taking concurrent methotrexate." @default.
• W2035741632 created "2016-06-24" @default.
• W2035741632 creator A5009104393 @default.
• W2035741632 creator A5031629161 @default.
• W2035741632 creator A5038128984 @default.
• W2035741632 creator A5055399648 @default.
• W2035741632 date "2004-11-01" @default.
• W2035741632 modified "2023-10-15" @default.
• W2035741632 title "Unaltered Etanercept Pharmacokinetics With Concurrent Methotrexate in Patients With Rheumatoid Arthritis" @default.
• W2035741632 cites W1528765374 @default.
• W2035741632 cites W1974415860 @default.
• W2035741632 cites W1979870628 @default.
• W2035741632 cites W1983510723 @default.
• W2035741632 cites W1983953162 @default.
• W2035741632 cites W1995333215 @default.
• W2035741632 cites W1996395903 @default.
• W2035741632 cites W2001477230 @default.
• W2035741632 cites W2005914922 @default.
• W2035741632 cites W2010660709 @default.
• W2035741632 cites W2017795093 @default.
• W2035741632 cites W2021908100 @default.
• W2035741632 cites W2030844903 @default.
• W2035741632 cites W2033537172 @default.
• W2035741632 cites W2038721188 @default.
• W2035741632 cites W2050487849 @default.
• W2035741632 cites W2059717105 @default.
• W2035741632 cites W2066469339 @default.
• W2035741632 cites W2095180242 @default.
• W2035741632 cites W2110915172 @default.
• W2035741632 cites W2116843833 @default.
• W2035741632 cites W2133816590 @default.
• W2035741632 cites W2159813162 @default.
• W2035741632 cites W2322242721 @default.
• W2035741632 cites W2327228702 @default.
• W2035741632 doi "https://doi.org/10.1177/0091270004268049" @default.
• W2035741632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15496641" @default.
• W2035741632 hasPublicationYear "2004" @default.
• W2035741632 type Work @default.
• W2035741632 sameAs 2035741632 @default.
• W2035741632 citedByCount "58" @default.
• W2035741632 countsByYear W20357416322012 @default.
• W2035741632 countsByYear W20357416322013 @default.
• W2035741632 countsByYear W20357416322014 @default.
• W2035741632 countsByYear W20357416322015 @default.
• W2035741632 countsByYear W20357416322016 @default.
• W2035741632 countsByYear W20357416322017 @default.
• W2035741632 countsByYear W20357416322019 @default.
• W2035741632 countsByYear W20357416322021 @default.
• W2035741632 countsByYear W20357416322022 @default.
• W2035741632 countsByYear W20357416322023 @default.
• W2035741632 crossrefType "journal-article" @default.
• W2035741632 hasAuthorship W2035741632A5009104393 @default.
• W2035741632 hasAuthorship W2035741632A5031629161 @default.
• W2035741632 hasAuthorship W2035741632A5038128984 @default.
• W2035741632 hasAuthorship W2035741632A5055399648 @default.
• W2035741632 hasConcept C112705442 @default.
• W2035741632 hasConcept C126322002 @default.
• W2035741632 hasConcept C2776239304 @default.
• W2035741632 hasConcept C2777077863 @default.
• W2035741632 hasConcept C2777226972 @default.
• W2035741632 hasConcept C2777575956 @default.
• W2035741632 hasConcept C2781059491 @default.
• W2035741632 hasConcept C2908647359 @default.
• W2035741632 hasConcept C71924100 @default.
• W2035741632 hasConcept C90924648 @default.
• W2035741632 hasConcept C98274493 @default.
• W2035741632 hasConcept C99454951 @default.
• W2035741632 hasConceptScore W2035741632C112705442 @default.
• W2035741632 hasConceptScore W2035741632C126322002 @default.
• W2035741632 hasConceptScore W2035741632C2776239304 @default.
• W2035741632 hasConceptScore W2035741632C2777077863 @default.
• W2035741632 hasConceptScore W2035741632C2777226972 @default.
• W2035741632 hasConceptScore W2035741632C2777575956 @default.
• W2035741632 hasConceptScore W2035741632C2781059491 @default.
• W2035741632 hasConceptScore W2035741632C2908647359 @default.
• W2035741632 hasConceptScore W2035741632C71924100 @default.
• W2035741632 hasConceptScore W2035741632C90924648 @default.
• W2035741632 hasConceptScore W2035741632C98274493 @default.
• W2035741632 hasConceptScore W2035741632C99454951 @default.
• W2035741632 hasIssue "11" @default.
• W2035741632 hasLocation W20357416321 @default.
• W2035741632 hasLocation W20357416322 @default.
• W2035741632 hasOpenAccess W2035741632 @default.
• W2035741632 hasPrimaryLocation W20357416321 @default.
• W2035741632 hasRelatedWork W2029474929 @default.
• W2035741632 hasRelatedWork W2058435704 @default.
• W2035741632 hasRelatedWork W2083278471 @default.
• W2035741632 hasRelatedWork W2106806370 @default.
• W2035741632 hasRelatedWork W2138243862 @default.
• W2035741632 hasRelatedWork W2314052274 @default.
• W2035741632 hasRelatedWork W2314544353 @default.
• W2035741632 hasRelatedWork W2411121127 @default.
• W2035741632 hasRelatedWork W4283524728 @default.
• W2035741632 hasRelatedWork W2314697596 @default.
• W2035741632 hasVolume "44" @default.
• W2035741632 isParatext "false" @default.
• W2035741632 isRetracted "false" @default.
• W2035741632 magId "2035741632" @default.

• next