FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035752492> ?p ?o ?g. }

• W2035752492 endingPage "e235" @default.
• W2035752492 startingPage "e235" @default.
• W2035752492 abstract "The leishmaniases are a group of vector-borne parasitic diseases that represent a major international public health problem; they belong to the most neglected tropical diseases and have one of the highest rates of morbidity and mortality. The clinical outcome of infection with Leishmania parasites depends on a variety of factors such as parasite species, vector-derived products, genetics, behaviour, and nutrition. The age of the infected individuals also appears to be critical, as a significant proportion of clinical cases occur in children; this age-related higher prevalence of disease is most remarkable in visceral leishmaniasis. The mechanisms resulting in this higher incidence of clinical disease in children are poorly understood. We have recently revealed that sustained arginase activity promotes uncontrolled parasite growth and pathology in vivo. Here, we tested the hypothesis that arginase-mediated L-arginine metabolism differs with age.The age distribution of patients with visceral or cutaneous leishmaniasis was determined in cohorts of patients in our clinics in endemic areas in Ethiopia. To exclude factors that are difficult to control in patients, we assessed the impact of ageing on the manifestations of experimental leishmaniasis. We determined parasite burden, T cell responses, and macrophage effector functions in young and aged mice during the course of infection.Our results show that younger mice develop exacerbated lesion pathology and higher parasite burdens than aged mice. This aggravated disease development in younger individuals does not correlate with a change in T helper cytokine profile. To address the underlying mechanisms responsible for the more severe infections in younger mice, we investigated macrophage effector functions. Our results show that macrophages from younger mice do not have an impaired capacity to kill parasites; however, they express significantly higher levels of arginase 1 than aged mice and promote parasite growth more efficiently. Thus, our results demonstrate that ageing differentially impacts on L-arginine metabolism and subsequent effector functions of physiologically distinct macrophage subsets.Here, we show that arginase-mediated L-arginine metabolism is modulated with age and affects the capacity of macrophages to express arginase; the increased capacity to upregulate this enzyme in younger individuals results in a more permissive environment for parasite growth, increased disease severity and pathology. These results suggest that the difference in arginase-mediated L-arginine catabolism is likely to be an important factor contributing to the increased incidence of clinical cases in children. Thus, targeting L-arginine metabolism might be a promising therapeutic strategy against leishmaniasis, especially in children and young adults." @default.
• W2035752492 created "2016-06-24" @default.
• W2035752492 creator A5006896277 @default.
• W2035752492 creator A5009372799 @default.
• W2035752492 creator A5012790380 @default.
• W2035752492 creator A5026942090 @default.
• W2035752492 creator A5033236441 @default.
• W2035752492 creator A5041374198 @default.
• W2035752492 creator A5073623750 @default.
• W2035752492 creator A5086720180 @default.
• W2035752492 date "2008-05-14" @default.
• W2035752492 modified "2023-09-27" @default.
• W2035752492 title "Age-Related Alteration of Arginase Activity Impacts on Severity of Leishmaniasis" @default.
• W2035752492 cites W1490035833 @default.
• W2035752492 cites W1558689307 @default.
• W2035752492 cites W1573977017 @default.
• W2035752492 cites W1653545152 @default.
• W2035752492 cites W1907207943 @default.
• W2035752492 cites W1954561760 @default.
• W2035752492 cites W1969610841 @default.
• W2035752492 cites W1974781378 @default.
• W2035752492 cites W1977893175 @default.
• W2035752492 cites W1980560557 @default.
• W2035752492 cites W1984188855 @default.
• W2035752492 cites W1988856386 @default.
• W2035752492 cites W1989387875 @default.
• W2035752492 cites W1991263982 @default.
• W2035752492 cites W1991484350 @default.
• W2035752492 cites W1994412261 @default.
• W2035752492 cites W1997496547 @default.
• W2035752492 cites W2002204067 @default.
• W2035752492 cites W2005596981 @default.
• W2035752492 cites W2005734580 @default.
• W2035752492 cites W2029886324 @default.
• W2035752492 cites W2034633641 @default.
• W2035752492 cites W2038425317 @default.
• W2035752492 cites W2038689279 @default.
• W2035752492 cites W2039763983 @default.
• W2035752492 cites W2045190214 @default.
• W2035752492 cites W2053697748 @default.
• W2035752492 cites W2065437997 @default.
• W2035752492 cites W2066052265 @default.
• W2035752492 cites W2069247542 @default.
• W2035752492 cites W2081973949 @default.
• W2035752492 cites W2088419426 @default.
• W2035752492 cites W2091832684 @default.
• W2035752492 cites W2098603140 @default.
• W2035752492 cites W2099930057 @default.
• W2035752492 cites W2102723906 @default.
• W2035752492 cites W2104513912 @default.
• W2035752492 cites W2115694713 @default.
• W2035752492 cites W2116694853 @default.
• W2035752492 cites W2126972146 @default.
• W2035752492 cites W2136118868 @default.
• W2035752492 cites W2139113002 @default.
• W2035752492 cites W2143043043 @default.
• W2035752492 cites W2152348400 @default.
• W2035752492 cites W2153690513 @default.
• W2035752492 cites W2154046127 @default.
• W2035752492 cites W2419604885 @default.
• W2035752492 doi "https://doi.org/10.1371/journal.pntd.0000235" @default.
• W2035752492 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2359854" @default.
• W2035752492 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18478052" @default.
• W2035752492 hasPublicationYear "2008" @default.
• W2035752492 type Work @default.
• W2035752492 sameAs 2035752492 @default.
• W2035752492 citedByCount "36" @default.
• W2035752492 countsByYear W20357524922012 @default.
• W2035752492 countsByYear W20357524922013 @default.
• W2035752492 countsByYear W20357524922014 @default.
• W2035752492 countsByYear W20357524922015 @default.
• W2035752492 countsByYear W20357524922016 @default.
• W2035752492 countsByYear W20357524922017 @default.
• W2035752492 countsByYear W20357524922018 @default.
• W2035752492 countsByYear W20357524922019 @default.
• W2035752492 countsByYear W20357524922020 @default.
• W2035752492 countsByYear W20357524922021 @default.
• W2035752492 countsByYear W20357524922022 @default.
• W2035752492 countsByYear W20357524922023 @default.
• W2035752492 crossrefType "journal-article" @default.
• W2035752492 hasAuthorship W2035752492A5006896277 @default.
• W2035752492 hasAuthorship W2035752492A5009372799 @default.
• W2035752492 hasAuthorship W2035752492A5012790380 @default.
• W2035752492 hasAuthorship W2035752492A5026942090 @default.
• W2035752492 hasAuthorship W2035752492A5033236441 @default.
• W2035752492 hasAuthorship W2035752492A5041374198 @default.
• W2035752492 hasAuthorship W2035752492A5073623750 @default.
• W2035752492 hasAuthorship W2035752492A5086720180 @default.
• W2035752492 hasBestOaLocation W20357524921 @default.
• W2035752492 hasConcept C120665830 @default.
• W2035752492 hasConcept C121332964 @default.
• W2035752492 hasConcept C126322002 @default.
• W2035752492 hasConcept C136764020 @default.
• W2035752492 hasConcept C164007495 @default.
• W2035752492 hasConcept C203014093 @default.
• W2035752492 hasConcept C2776555147 @default.
• W2035752492 hasConcept C2777468819 @default.
• W2035752492 hasConcept C2778689377 @default.

• next