FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035754178> ?p ?o ?g. }

• W2035754178 endingPage "921" @default.
• W2035754178 startingPage "914" @default.
• W2035754178 abstract "Atopic dermatitis (AD) is an inflammatory skin disease arising as a result of immune system and skin barrier defects. Topical corticosteroids are safe and effective treatments for AD, when used in short courses. Prolonged use is associated with skin barrier damage. Topical calcineurin inhibitors are alternative immune‐modulating treatments for AD purported to have no negative effects on the skin barrier. To compare the effects of betamethasone valerate 0·1% cream (BMVc) and tacrolimus 0·1% ointment (TACo) on the skin barrier. Twenty volunteers with quiescent AD (no active signs for 6 months) participated in a randomized observer‐blind study, wherein BMVc was applied to one forearm and TACo to the other, twice daily for 4 weeks. The biophysical/biological properties of the stratum corneum were assessed before and after treatment. Nine volunteers with active disease and 10 with healthy skin were assessed at untreated sites. BMVc significantly reduced skin barrier function, integrity and cohesion, and the levels of pyrrolidone carboxylic acid (PCA) and urocanic acid (UCA) towards the subclinical barrier defect observed in patients with AD (nonlesional sites). TACo preserved skin barrier function, integrity, cohesion and PCA and UCA levels, while significantly increasing skin hydration to levels comparable with healthy skin. Both treatments reduced skin surface pH and trypsin‐like protease activity, with TACo doing so to a significantly greater degree. In quiescent AD, 4 weeks of BMVc treatment adversely affected the biophysical properties of the skin and reduced the levels of natural moisturizing factor, whereas TACo improved the condition of the skin barrier." @default.
• W2035754178 created "2016-06-24" @default.
• W2035754178 creator A5003135282 @default.
• W2035754178 creator A5026072584 @default.
• W2035754178 creator A5026963044 @default.
• W2035754178 creator A5036775839 @default.
• W2035754178 creator A5039406895 @default.
• W2035754178 date "2014-04-01" @default.
• W2035754178 modified "2023-10-14" @default.
• W2035754178 title "The effect of tacrolimus compared with betamethasone valerate on the skin barrier in volunteers with quiescent atopic dermatitis" @default.
• W2035754178 cites W1489049801 @default.
• W2035754178 cites W1502871095 @default.
• W2035754178 cites W1559988601 @default.
• W2035754178 cites W1605295219 @default.
• W2035754178 cites W1960933454 @default.
• W2035754178 cites W1966013432 @default.
• W2035754178 cites W1967102600 @default.
• W2035754178 cites W1969563500 @default.
• W2035754178 cites W1979267735 @default.
• W2035754178 cites W1979366593 @default.
• W2035754178 cites W1980089744 @default.
• W2035754178 cites W2027262352 @default.
• W2035754178 cites W2028590815 @default.
• W2035754178 cites W2035607932 @default.
• W2035754178 cites W2040391898 @default.
• W2035754178 cites W2042984025 @default.
• W2035754178 cites W2057098942 @default.
• W2035754178 cites W2060604544 @default.
• W2035754178 cites W2066620976 @default.
• W2035754178 cites W2067548168 @default.
• W2035754178 cites W2068176013 @default.
• W2035754178 cites W2070602264 @default.
• W2035754178 cites W2091490015 @default.
• W2035754178 cites W2094616623 @default.
• W2035754178 cites W2109645710 @default.
• W2035754178 cites W2144344238 @default.
• W2035754178 cites W2149859111 @default.
• W2035754178 cites W2150229563 @default.
• W2035754178 cites W2159271088 @default.
• W2035754178 cites W4246102039 @default.
• W2035754178 cites W4296927509 @default.
• W2035754178 cites W4297627414 @default.
• W2035754178 doi "https://doi.org/10.1111/bjd.12778" @default.
• W2035754178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24328907" @default.
• W2035754178 hasPublicationYear "2014" @default.
• W2035754178 type Work @default.
• W2035754178 sameAs 2035754178 @default.
• W2035754178 citedByCount "60" @default.
• W2035754178 countsByYear W20357541782014 @default.
• W2035754178 countsByYear W20357541782015 @default.
• W2035754178 countsByYear W20357541782016 @default.
• W2035754178 countsByYear W20357541782017 @default.
• W2035754178 countsByYear W20357541782018 @default.
• W2035754178 countsByYear W20357541782019 @default.
• W2035754178 countsByYear W20357541782020 @default.
• W2035754178 countsByYear W20357541782021 @default.
• W2035754178 countsByYear W20357541782022 @default.
• W2035754178 countsByYear W20357541782023 @default.
• W2035754178 crossrefType "journal-article" @default.
• W2035754178 hasAuthorship W2035754178A5003135282 @default.
• W2035754178 hasAuthorship W2035754178A5026072584 @default.
• W2035754178 hasAuthorship W2035754178A5026963044 @default.
• W2035754178 hasAuthorship W2035754178A5036775839 @default.
• W2035754178 hasAuthorship W2035754178A5039406895 @default.
• W2035754178 hasBestOaLocation W20357541781 @default.
• W2035754178 hasConcept C126322002 @default.
• W2035754178 hasConcept C128057223 @default.
• W2035754178 hasConcept C142724271 @default.
• W2035754178 hasConcept C16005928 @default.
• W2035754178 hasConcept C2778329239 @default.
• W2035754178 hasConcept C2778370115 @default.
• W2035754178 hasConcept C2909675724 @default.
• W2035754178 hasConcept C2911091166 @default.
• W2035754178 hasConcept C2991981033 @default.
• W2035754178 hasConcept C51911345 @default.
• W2035754178 hasConcept C71924100 @default.
• W2035754178 hasConcept C86803240 @default.
• W2035754178 hasConcept C95150158 @default.
• W2035754178 hasConcept C95444343 @default.
• W2035754178 hasConcept C98274493 @default.
• W2035754178 hasConceptScore W2035754178C126322002 @default.
• W2035754178 hasConceptScore W2035754178C128057223 @default.
• W2035754178 hasConceptScore W2035754178C142724271 @default.
• W2035754178 hasConceptScore W2035754178C16005928 @default.
• W2035754178 hasConceptScore W2035754178C2778329239 @default.
• W2035754178 hasConceptScore W2035754178C2778370115 @default.
• W2035754178 hasConceptScore W2035754178C2909675724 @default.
• W2035754178 hasConceptScore W2035754178C2911091166 @default.
• W2035754178 hasConceptScore W2035754178C2991981033 @default.
• W2035754178 hasConceptScore W2035754178C51911345 @default.
• W2035754178 hasConceptScore W2035754178C71924100 @default.
• W2035754178 hasConceptScore W2035754178C86803240 @default.
• W2035754178 hasConceptScore W2035754178C95150158 @default.
• W2035754178 hasConceptScore W2035754178C95444343 @default.
• W2035754178 hasConceptScore W2035754178C98274493 @default.
• W2035754178 hasIssue "4" @default.
• W2035754178 hasLocation W20357541781 @default.
• W2035754178 hasLocation W20357541782 @default.

• next