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- W2035758416 abstract "Wake-promoting drugs are widely used to treat excessive daytime sleepiness. The neuronal pathways involved in wake promotion are multiple and often not well characterized. We tested d-amphetamine, modafinil, and YKP10A, a novel wake-promoting compound, in three inbred strains of mice. The wake duration induced by YKP10A and d-amphetamine depended similarly on genotype, whereas opposite strain differences were observed after modafinil. Electroencephalogram (EEG) analysis during drug-induced wakefulness revealed a transient ∼2 Hz slowing of theta oscillations and an increase in beta-2 (20–35 Hz) activity only after YKP10A. Gamma activity (35–60 Hz) was induced by all drugs in a drug- and genotype-dependent manner. Brain transcriptome and clustering analyses indicated that the three drugs have both common and specific molecular signatures. The correlation between specific EEG and gene-expression signatures suggests that the neuronal pathways activated to stay awake vary among drugs and genetic background." @default.
- W2035758416 created "2016-06-24" @default.
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- W2035758416 date "2009-02-04" @default.
- W2035758416 modified "2023-10-05" @default.
- W2035758416 title "How to Keep the Brain Awake? The Complex Molecular Pharmacogenetics of Wake Promotion" @default.
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- W2035758416 doi "https://doi.org/10.1038/npp.2009.3" @default.
- W2035758416 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19194377" @default.
- W2035758416 hasPublicationYear "2009" @default.
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