FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035758977> ?p ?o ?g. }

• W2035758977 endingPage "H795" @default.
• W2035758977 startingPage "H789" @default.
• W2035758977 abstract "It has been suggested that oxidative stress contributes to impaired left ventricular (LV) contractility in the setting of heart failure (HF). To test this hypothesis, we studied the effect of an antioxidant on contractility at rest and in response to dobutamine in 10 HF patients. We hypothesized that vitamin C would augment contractility in HF and that this effect would be of a greater magnitude in HF patients compared with patients with normal LV (NLV) function. Data from 10 patients with NLV function who participated in this study are included in this report and have been published elsewhere. A micromanometer-tipped catheter was introduced into the LV. In the experimental protocol, an infusion catheter was positioned in the left main coronary artery. The peak positive rate of change of LV pressure (LV +dP/dt) was measured in response to the intravenous infusion of dobutamine before and during the intracoronary infusion of vitamin C (96 mg/min). Vitamin C had no effect on basal LV +dP/dt in either HF or NLV groups. The infusion of vitamin C augmented the LV +dP/dt response to dobutamine by 22 +/- 4% in the NLV function group. In contrast, vitamin C had no effect on the inotropic response to dobutamine in the HF group. In the control protocol, without vitamin C, no differences were observed between responses to two sequential dobutamine infusions in either group (HF, n = 11; NLV, n = 9). Therefore, a positive effect of vitamin C on contractility was limited to patients with NLV function. The absence of this effect in HF patients may suggest that normal redox responsiveness is lost in this disease state." @default.
• W2035758977 created "2016-06-24" @default.
• W2035758977 creator A5056386054 @default.
• W2035758977 creator A5080049440 @default.
• W2035758977 date "2004-02-01" @default.
• W2035758977 modified "2023-10-15" @default.
• W2035758977 title "Redox modulation of the inotropic response to dobutamine is impaired in patients with heart failure" @default.
• W2035758977 cites W120083757 @default.
• W2035758977 cites W1483108854 @default.
• W2035758977 cites W154216494 @default.
• W2035758977 cites W1566419077 @default.
• W2035758977 cites W1681119270 @default.
• W2035758977 cites W1887679324 @default.
• W2035758977 cites W1971167098 @default.
• W2035758977 cites W1987186368 @default.
• W2035758977 cites W1992815766 @default.
• W2035758977 cites W1995078408 @default.
• W2035758977 cites W1997731166 @default.
• W2035758977 cites W2009028175 @default.
• W2035758977 cites W2011419396 @default.
• W2035758977 cites W2015380696 @default.
• W2035758977 cites W2020783425 @default.
• W2035758977 cites W2021901278 @default.
• W2035758977 cites W2025071415 @default.
• W2035758977 cites W2035788315 @default.
• W2035758977 cites W2036718044 @default.
• W2035758977 cites W2038981124 @default.
• W2035758977 cites W2049395037 @default.
• W2035758977 cites W2051379551 @default.
• W2035758977 cites W2053987168 @default.
• W2035758977 cites W2068353537 @default.
• W2035758977 cites W2068735811 @default.
• W2035758977 cites W2074030075 @default.
• W2035758977 cites W2079327708 @default.
• W2035758977 cites W2083504857 @default.
• W2035758977 cites W2084327878 @default.
• W2035758977 cites W2087018994 @default.
• W2035758977 cites W2087492842 @default.
• W2035758977 cites W2090041904 @default.
• W2035758977 cites W2090881549 @default.
• W2035758977 cites W2092493326 @default.
• W2035758977 cites W2093857799 @default.
• W2035758977 cites W2094127775 @default.
• W2035758977 cites W2098503682 @default.
• W2035758977 cites W2098950302 @default.
• W2035758977 cites W2109893157 @default.
• W2035758977 cites W2120798894 @default.
• W2035758977 cites W2128476058 @default.
• W2035758977 cites W2129194977 @default.
• W2035758977 cites W2129276307 @default.
• W2035758977 cites W2135122986 @default.
• W2035758977 cites W2153256705 @default.
• W2035758977 cites W2155603952 @default.
• W2035758977 cites W2156094488 @default.
• W2035758977 cites W2162394869 @default.
• W2035758977 cites W2166218864 @default.
• W2035758977 cites W2185158722 @default.
• W2035758977 cites W2264654339 @default.
• W2035758977 cites W2405339182 @default.
• W2035758977 cites W2626456589 @default.
• W2035758977 cites W4233656649 @default.
• W2035758977 doi "https://doi.org/10.1152/ajpheart.00633.2003" @default.
• W2035758977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14551049" @default.
• W2035758977 hasPublicationYear "2004" @default.
• W2035758977 type Work @default.
• W2035758977 sameAs 2035758977 @default.
• W2035758977 citedByCount "17" @default.
• W2035758977 countsByYear W20357589772012 @default.
• W2035758977 countsByYear W20357589772013 @default.
• W2035758977 countsByYear W20357589772018 @default.
• W2035758977 countsByYear W20357589772021 @default.
• W2035758977 crossrefType "journal-article" @default.
• W2035758977 hasAuthorship W2035758977A5056386054 @default.
• W2035758977 hasAuthorship W2035758977A5080049440 @default.
• W2035758977 hasConcept C126322002 @default.
• W2035758977 hasConcept C155710745 @default.
• W2035758977 hasConcept C164705383 @default.
• W2035758977 hasConcept C178853913 @default.
• W2035758977 hasConcept C2778024521 @default.
• W2035758977 hasConcept C2778198053 @default.
• W2035758977 hasConcept C2779306644 @default.
• W2035758977 hasConcept C2781185063 @default.
• W2035758977 hasConcept C39133596 @default.
• W2035758977 hasConcept C71924100 @default.
• W2035758977 hasConceptScore W2035758977C126322002 @default.
• W2035758977 hasConceptScore W2035758977C155710745 @default.
• W2035758977 hasConceptScore W2035758977C164705383 @default.
• W2035758977 hasConceptScore W2035758977C178853913 @default.
• W2035758977 hasConceptScore W2035758977C2778024521 @default.
• W2035758977 hasConceptScore W2035758977C2778198053 @default.
• W2035758977 hasConceptScore W2035758977C2779306644 @default.
• W2035758977 hasConceptScore W2035758977C2781185063 @default.
• W2035758977 hasConceptScore W2035758977C39133596 @default.
• W2035758977 hasConceptScore W2035758977C71924100 @default.
• W2035758977 hasIssue "2" @default.
• W2035758977 hasLocation W20357589771 @default.
• W2035758977 hasLocation W20357589772 @default.
• W2035758977 hasOpenAccess W2035758977 @default.

• next