FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035774412> ?p ?o ?g. }

• W2035774412 endingPage "971" @default.
• W2035774412 startingPage "962" @default.
• W2035774412 abstract "We hypothesized that the alveolar structures may contain extracellular macromolecules with antioxidant properties to defend against oxidants. To evaluate this 51Cr-labeled human lung fibroblasts (HFL-1) and cat lung epithelial cells (AKD) were exposed to a H2O2-generating system and alveolar epithelial lining fluid (ELF) from healthy nonsmokers was tested for its ability to protect the lung cells from H2O2-mediated injury. The ELF provided marked antioxidant protection, with most from a H2O-soluble fraction in the 100-300-kD range. Plasma proteins with anti-H2O2 properties were in insufficient concentrations to provide the antioxidant protection observed. However, catalase, a normal intracellular antioxidant, was present in sufficient concentration to account for most of the observed anti-H2O2 properties of ELF. Depletion of ELF with an anticatalase antibody abolished the anti-H2O2 macromolecular defenses of ELF. Since catalase is not normally released by cells, a likely explanation for its presence in high concentrations in normal ELF is that it is released by lung inflammatory and parenchymal cells onto the epithelial surface of the lower respiratory tract during their normal turnover and collects there due to the slow turnover of ELF. It is likely that catalase in the ELF of normal individuals plays a role in protecting lung parenchymal cells against oxidants present in the extracellular milieu." @default.
• W2035774412 created "2016-06-24" @default.
• W2035774412 creator A5036550158 @default.
• W2035774412 creator A5046812157 @default.
• W2035774412 creator A5052160402 @default.
• W2035774412 creator A5064433832 @default.
• W2035774412 date "1990-09-01" @default.
• W2035774412 modified "2023-10-18" @default.
• W2035774412 title "Antioxidant macromolecules in the epithelial lining fluid of the normal human lower respiratory tract." @default.
• W2035774412 cites W1027013673 @default.
• W2035774412 cites W1030653330 @default.
• W2035774412 cites W1882289051 @default.
• W2035774412 cites W1917517429 @default.
• W2035774412 cites W191793640 @default.
• W2035774412 cites W1949711541 @default.
• W2035774412 cites W1965340455 @default.
• W2035774412 cites W1975473360 @default.
• W2035774412 cites W1976913935 @default.
• W2035774412 cites W1982167041 @default.
• W2035774412 cites W1990218449 @default.
• W2035774412 cites W1995200391 @default.
• W2035774412 cites W199546825 @default.
• W2035774412 cites W2007248764 @default.
• W2035774412 cites W2020534933 @default.
• W2035774412 cites W2023122744 @default.
• W2035774412 cites W2024624247 @default.
• W2035774412 cites W2029615573 @default.
• W2035774412 cites W2029758491 @default.
• W2035774412 cites W2030531215 @default.
• W2035774412 cites W2032073869 @default.
• W2035774412 cites W2045535103 @default.
• W2035774412 cites W2048062311 @default.
• W2035774412 cites W2056168344 @default.
• W2035774412 cites W2058388216 @default.
• W2035774412 cites W2078195249 @default.
• W2035774412 cites W2089046319 @default.
• W2035774412 cites W2099506873 @default.
• W2035774412 cites W2099728245 @default.
• W2035774412 cites W2101518804 @default.
• W2035774412 cites W2123287803 @default.
• W2035774412 cites W2129707656 @default.
• W2035774412 cites W2132826785 @default.
• W2035774412 cites W2138276518 @default.
• W2035774412 cites W2154563160 @default.
• W2035774412 cites W2162506840 @default.
• W2035774412 cites W2168518837 @default.
• W2035774412 cites W2171679874 @default.
• W2035774412 cites W2174934515 @default.
• W2035774412 cites W2182425168 @default.
• W2035774412 cites W2201403940 @default.
• W2035774412 cites W2238950535 @default.
• W2035774412 cites W2297947946 @default.
• W2035774412 cites W2408922396 @default.
• W2035774412 cites W2413195763 @default.
• W2035774412 cites W2416220586 @default.
• W2035774412 cites W2430138730 @default.
• W2035774412 cites W2886968656 @default.
• W2035774412 cites W4211054414 @default.
• W2035774412 cites W9619468 @default.
• W2035774412 doi "https://doi.org/10.1172/jci114798" @default.
• W2035774412 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/296816" @default.
• W2035774412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2394842" @default.
• W2035774412 hasPublicationYear "1990" @default.
• W2035774412 type Work @default.
• W2035774412 sameAs 2035774412 @default.
• W2035774412 citedByCount "124" @default.
• W2035774412 countsByYear W20357744122012 @default.
• W2035774412 countsByYear W20357744122014 @default.
• W2035774412 countsByYear W20357744122016 @default.
• W2035774412 countsByYear W20357744122017 @default.
• W2035774412 countsByYear W20357744122018 @default.
• W2035774412 countsByYear W20357744122019 @default.
• W2035774412 countsByYear W20357744122020 @default.
• W2035774412 countsByYear W20357744122021 @default.
• W2035774412 countsByYear W20357744122022 @default.
• W2035774412 countsByYear W20357744122023 @default.
• W2035774412 crossrefType "journal-article" @default.
• W2035774412 hasAuthorship W2035774412A5036550158 @default.
• W2035774412 hasAuthorship W2035774412A5046812157 @default.
• W2035774412 hasAuthorship W2035774412A5052160402 @default.
• W2035774412 hasAuthorship W2035774412A5064433832 @default.
• W2035774412 hasBestOaLocation W20357744121 @default.
• W2035774412 hasConcept C105702510 @default.
• W2035774412 hasConcept C126322002 @default.
• W2035774412 hasConcept C142724271 @default.
• W2035774412 hasConcept C185592680 @default.
• W2035774412 hasConcept C196822366 @default.
• W2035774412 hasConcept C203014093 @default.
• W2035774412 hasConcept C2777714996 @default.
• W2035774412 hasConcept C2778004101 @default.
• W2035774412 hasConcept C2778979269 @default.
• W2035774412 hasConcept C2779644171 @default.
• W2035774412 hasConcept C28406088 @default.
• W2035774412 hasConcept C534529494 @default.
• W2035774412 hasConcept C55493867 @default.
• W2035774412 hasConcept C71924100 @default.
• W2035774412 hasConcept C79879829 @default.
• W2035774412 hasConcept C86803240 @default.

• next