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• W2035782808 abstract "Setting: HLA and tuberculin status in pulmonary tuberculosis patients. Tuberculosis Research Centre, Indian Council of Medical Research, Madras, India. Objective: To elucidate the role of HLA-class-II genes/gene products on tuberculin reactivity in pulmonary tuberculosis patients. Design: Serological determination of HLA-DR and -DQ antigens was carried out in 62 healthy control subjects and 146 pulmonary tuberculosis patients. The tuberculin reaction pattern of pulmonary tuberculosis patients to PPD was studied and the role of HLA-DR and -DQ antigens (class-II gene products) on tuberculin reaction was analysed. Results: HLA-DR and -DQ antigens did not influence high, medium and low tuberculin reaction dramatically in active pulmonary tuberculosis patients. However, a heterozygous combination of various HLA-DR antigens influenced the tuberculin reaction. Conclusion: The HLA-genetic make up (heterozygous combination) of the individual may influence the tuberculin reaction pattern in pulmonary tuberculosis. Cadre: HLA et réaction tuberculinique chez des malades atteints d'une tuberculose pulmonaire. Centre de recherche de la tuberculose, Indian Council of Medical Research, Madras, Inde. Objectif: Elucider le rôle des gènes ou des produits géniques HLA-classe-II sur la réactivité tuberculinique des patients atteints de tuberculose pulmonaire. Schéma: La détermination sérologique des antigènes HLA-DR et -DQ a été conduite chez 62 sujets-contrôle bien portants et chez 146 tuberculeux pulmonaires. Le type de réaction tuberculinique des patients atteints de tuberculose pulmonaire et testés par la PPD a été étudié et l'influence des antigènes HLA-DR et -DQ (produits géniques de classe II) sur la réaction tuberculinique a été analysé. Résultants: Chez des patients atteints de tuberculose pulmonaire active, les antigènes HLA-DR et -DQ n'influencent pas de façon dramatique la réaction tuberculinique forte, moyenne ou faible. Toutefois, une combinaison hétérozygote de différents antigènes HLA-DR joue un rôle sur la réaction tuberculinique. Conclusion: La structure génétique HLA (combinaison hétérozygote) de l'individu peut influencer le type de réaction tuberculinique dans la tuberculose pulmonaire. Marco de referencia: Sistema HLA y reactividad tuberculínica en pacientes con tuberculosis pulmonar. Centro de Investigaciones en Tuberculosis. Indian Council of Medical Research, Madras, India. Objetivo: Elucidar el papel de los genes o de los productos génicos HLA-clase-II en la reactividad tuberculínica de los pacientes con tuberculosis pulmonar. Método: Se efectuó la determinación serológica de los antígenos HLA-DR y -DQ en 62 controles sanos y en 146 pacientes con tuberculosis pulmonar. Se estudió el tipo de reacción tuberculínica al PPD de los pacientes con tuberculosis pulmonar y se analizó la influencia de los antígenos HLA-DR y -DQ (productos génicos de clase II) sobre la reacción a la tuberculina. Resultados: Los antígenos HLA-DR y -DQ no influencian de manera importante las reacciones intensas, medianas o débiles a la tuberculina en los pacientes con tuberculosis pulmonar activa. Sin embargo una combinación heterozigota de diversos antígenos HLA-DR tiene una influencia sobre la reacción a la tuberculina. Conclusión: La estructura genética HLA (combinación heterozigota) del individuo puede influenciar el tipo de reacción tuberculínica en la tuberculosis pulmonar." @default.
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• W2035782808 title "Influence of HLA-DR and -DQ phenotypes on tuberculin reactive status in pulmonary tuberculosis patients" @default.
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• W2035782808 doi "https://doi.org/10.1016/s0962-8479(96)90104-5" @default.
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