FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035786823> ?p ?o ?g. }

• W2035786823 endingPage "815" @default.
• W2035786823 startingPage "809" @default.
• W2035786823 abstract "Activation of phospholipase A2 (PLA2) upon binding to phospholipid assemblies is poorly understood. X-ray crystallography revealed little structural change in the enzyme upon binding of monomeric substrate analogs, whereas small conformational changes in PLA2 complexed with substrate micelles and an inhibitor were found by NMR. The structure of PLA2 bound to phospholipid bilayers is not known. Here we uncover by FTIR spectroscopy a splitting in the alpha-helical region of the amide I absorbance band of PLA2 upon binding to lipid bilayers. We provide evidence that a higher frequency component, which is only observed in the membrane-bound enzyme, is a property of more flexible helices. Formation of flexible helices upon interaction with the membrane is likely to contribute to PLA2 activation." @default.
• W2035786823 created "2016-06-24" @default.
• W2035786823 creator A5021277644 @default.
• W2035786823 creator A5068810331 @default.
• W2035786823 creator A5078777363 @default.
• W2035786823 date "1997-05-01" @default.
• W2035786823 modified "2023-10-14" @default.
• W2035786823 title "Structural changes in a secretory phospholipase A2 Induced by membrane binding: a clue to interfacial activation?" @default.
• W2035786823 cites W1028073060 @default.
• W2035786823 cites W116055455 @default.
• W2035786823 cites W1501888177 @default.
• W2035786823 cites W1508039024 @default.
• W2035786823 cites W1573258040 @default.
• W2035786823 cites W1586833407 @default.
• W2035786823 cites W1608557156 @default.
• W2035786823 cites W1934853983 @default.
• W2035786823 cites W1966913397 @default.
• W2035786823 cites W1967324212 @default.
• W2035786823 cites W1969651594 @default.
• W2035786823 cites W1987205935 @default.
• W2035786823 cites W1990502906 @default.
• W2035786823 cites W1990993880 @default.
• W2035786823 cites W1992315080 @default.
• W2035786823 cites W1996341064 @default.
• W2035786823 cites W2015942817 @default.
• W2035786823 cites W2017766716 @default.
• W2035786823 cites W2027897016 @default.
• W2035786823 cites W2032408951 @default.
• W2035786823 cites W2053893385 @default.
• W2035786823 cites W2062972508 @default.
• W2035786823 cites W2078386027 @default.
• W2035786823 cites W2080550444 @default.
• W2035786823 cites W2081469000 @default.
• W2035786823 cites W2093545639 @default.
• W2035786823 cites W2096096102 @default.
• W2035786823 cites W2106150672 @default.
• W2035786823 cites W2126784862 @default.
• W2035786823 cites W2150384032 @default.
• W2035786823 cites W2411324441 @default.
• W2035786823 cites W4239102874 @default.
• W2035786823 doi "https://doi.org/10.1006/jmbi.1997.1014" @default.
• W2035786823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9180373" @default.
• W2035786823 hasPublicationYear "1997" @default.
• W2035786823 type Work @default.
• W2035786823 sameAs 2035786823 @default.
• W2035786823 citedByCount "70" @default.
• W2035786823 countsByYear W20357868232012 @default.
• W2035786823 countsByYear W20357868232013 @default.
• W2035786823 countsByYear W20357868232014 @default.
• W2035786823 countsByYear W20357868232015 @default.
• W2035786823 countsByYear W20357868232016 @default.
• W2035786823 countsByYear W20357868232018 @default.
• W2035786823 countsByYear W20357868232019 @default.
• W2035786823 countsByYear W20357868232020 @default.
• W2035786823 crossrefType "journal-article" @default.
• W2035786823 hasAuthorship W2035786823A5021277644 @default.
• W2035786823 hasAuthorship W2035786823A5068810331 @default.
• W2035786823 hasAuthorship W2035786823A5078777363 @default.
• W2035786823 hasConcept C11268172 @default.
• W2035786823 hasConcept C12554922 @default.
• W2035786823 hasConcept C166940927 @default.
• W2035786823 hasConcept C178790620 @default.
• W2035786823 hasConcept C181199279 @default.
• W2035786823 hasConcept C184651966 @default.
• W2035786823 hasConcept C185592680 @default.
• W2035786823 hasConcept C18903297 @default.
• W2035786823 hasConcept C2776551241 @default.
• W2035786823 hasConcept C2777289219 @default.
• W2035786823 hasConcept C2777339483 @default.
• W2035786823 hasConcept C2778918659 @default.
• W2035786823 hasConcept C39944091 @default.
• W2035786823 hasConcept C41625074 @default.
• W2035786823 hasConcept C47701112 @default.
• W2035786823 hasConcept C521977710 @default.
• W2035786823 hasConcept C55493867 @default.
• W2035786823 hasConcept C71240020 @default.
• W2035786823 hasConcept C8010536 @default.
• W2035786823 hasConcept C86803240 @default.
• W2035786823 hasConceptScore W2035786823C11268172 @default.
• W2035786823 hasConceptScore W2035786823C12554922 @default.
• W2035786823 hasConceptScore W2035786823C166940927 @default.
• W2035786823 hasConceptScore W2035786823C178790620 @default.
• W2035786823 hasConceptScore W2035786823C181199279 @default.
• W2035786823 hasConceptScore W2035786823C184651966 @default.
• W2035786823 hasConceptScore W2035786823C185592680 @default.
• W2035786823 hasConceptScore W2035786823C18903297 @default.
• W2035786823 hasConceptScore W2035786823C2776551241 @default.
• W2035786823 hasConceptScore W2035786823C2777289219 @default.
• W2035786823 hasConceptScore W2035786823C2777339483 @default.
• W2035786823 hasConceptScore W2035786823C2778918659 @default.
• W2035786823 hasConceptScore W2035786823C39944091 @default.
• W2035786823 hasConceptScore W2035786823C41625074 @default.
• W2035786823 hasConceptScore W2035786823C47701112 @default.
• W2035786823 hasConceptScore W2035786823C521977710 @default.
• W2035786823 hasConceptScore W2035786823C55493867 @default.
• W2035786823 hasConceptScore W2035786823C71240020 @default.
• W2035786823 hasConceptScore W2035786823C8010536 @default.
• W2035786823 hasConceptScore W2035786823C86803240 @default.

• next