FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035794173> ?p ?o ?g. }

• W2035794173 endingPage "14" @default.
• W2035794173 startingPage "1" @default.
• W2035794173 abstract "The aim of the present investigation was to elucidate the cellular mechanisms whereby Tanshinone IIA (Tan IIA) leads to cell cycle arrest and apoptosis in vitro in keratinocytes, the target cells in psoriasis. Tan IIA inhibited proliferation of mouse keratinocytes in a dose- and time-dependent manner and induced apoptosis, resulting in S phase arrest accompanied by down-regulation of pCdk2 and cyclin A protein expression. Furthermore, Tan IIA-induced apoptosis and mitochondrial membrane potential changes were also further demonstrated by DNA fragmentation, single-cell gel electrophoresis assay (SCGE), and flow cytometry methods. Apoptosis was partially blocked by the caspase-3 inhibitor Ac-DEVD-CHO. Mitochondrial regulation of apoptosis further downstream was investigated, showing changes in the mitochondrial membrane potential, cytochrome c release into the cytoplasm, and enhanced activation of cleaved caspase-3 and Poly ADP-ribose polymerase (PARP). There was also no translocation of apoptosis-inducing factor (AIF) from mitochondria to the nucleus in apoptotic keratinocytes, indicating Tan IIA-induced apoptosis occurs mainly through the caspase pathway. Our findings provide the molecular mechanisms by which Tan IIA can be used to treat psoriasis and support the traditional use of Salvia miltiorrhiza Bungee (Labiatae) for psoriasis and related skin diseases." @default.
• W2035794173 created "2016-06-24" @default.
• W2035794173 creator A5010479652 @default.
• W2035794173 creator A5015540596 @default.
• W2035794173 creator A5022526821 @default.
• W2035794173 creator A5029695887 @default.
• W2035794173 creator A5029941351 @default.
• W2035794173 creator A5031378203 @default.
• W2035794173 creator A5043300709 @default.
• W2035794173 creator A5050134236 @default.
• W2035794173 creator A5067989213 @default.
• W2035794173 date "2012-01-01" @default.
• W2035794173 modified "2023-10-15" @default.
• W2035794173 title "Tanshinone IIA Inhibits Growth of Keratinocytes through Cell Cycle Arrest and Apoptosis: Underlying Treatment Mechanism of Psoriasis" @default.
• W2035794173 cites W151366572 @default.
• W2035794173 cites W1599097787 @default.
• W2035794173 cites W1984975924 @default.
• W2035794173 cites W1986568749 @default.
• W2035794173 cites W1988367097 @default.
• W2035794173 cites W1997021011 @default.
• W2035794173 cites W2002682915 @default.
• W2035794173 cites W2005962215 @default.
• W2035794173 cites W2006547874 @default.
• W2035794173 cites W2027941153 @default.
• W2035794173 cites W2049218448 @default.
• W2035794173 cites W2052221882 @default.
• W2035794173 cites W2066571367 @default.
• W2035794173 cites W2070108701 @default.
• W2035794173 cites W2071479387 @default.
• W2035794173 cites W2080266238 @default.
• W2035794173 cites W2081366440 @default.
• W2035794173 cites W2087327923 @default.
• W2035794173 cites W2098657730 @default.
• W2035794173 cites W2110480353 @default.
• W2035794173 cites W2123671636 @default.
• W2035794173 cites W2127324182 @default.
• W2035794173 cites W2130623329 @default.
• W2035794173 cites W2139864853 @default.
• W2035794173 cites W2156676081 @default.
• W2035794173 cites W2159650080 @default.
• W2035794173 cites W2169790726 @default.
• W2035794173 cites W22855108 @default.
• W2035794173 doi "https://doi.org/10.1155/2012/927658" @default.
• W2035794173 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3236062" @default.
• W2035794173 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22203883" @default.
• W2035794173 hasPublicationYear "2012" @default.
• W2035794173 type Work @default.
• W2035794173 sameAs 2035794173 @default.
• W2035794173 citedByCount "22" @default.
• W2035794173 countsByYear W20357941732012 @default.
• W2035794173 countsByYear W20357941732013 @default.
• W2035794173 countsByYear W20357941732014 @default.
• W2035794173 countsByYear W20357941732015 @default.
• W2035794173 countsByYear W20357941732016 @default.
• W2035794173 countsByYear W20357941732018 @default.
• W2035794173 countsByYear W20357941732019 @default.
• W2035794173 countsByYear W20357941732020 @default.
• W2035794173 countsByYear W20357941732021 @default.
• W2035794173 countsByYear W20357941732022 @default.
• W2035794173 countsByYear W20357941732023 @default.
• W2035794173 crossrefType "journal-article" @default.
• W2035794173 hasAuthorship W2035794173A5010479652 @default.
• W2035794173 hasAuthorship W2035794173A5015540596 @default.
• W2035794173 hasAuthorship W2035794173A5022526821 @default.
• W2035794173 hasAuthorship W2035794173A5029695887 @default.
• W2035794173 hasAuthorship W2035794173A5029941351 @default.
• W2035794173 hasAuthorship W2035794173A5031378203 @default.
• W2035794173 hasAuthorship W2035794173A5043300709 @default.
• W2035794173 hasAuthorship W2035794173A5050134236 @default.
• W2035794173 hasAuthorship W2035794173A5067989213 @default.
• W2035794173 hasBestOaLocation W20357941731 @default.
• W2035794173 hasConcept C105696609 @default.
• W2035794173 hasConcept C153911025 @default.
• W2035794173 hasConcept C182979987 @default.
• W2035794173 hasConcept C185592680 @default.
• W2035794173 hasConcept C190283241 @default.
• W2035794173 hasConcept C28859421 @default.
• W2035794173 hasConcept C29311851 @default.
• W2035794173 hasConcept C29537977 @default.
• W2035794173 hasConcept C31573885 @default.
• W2035794173 hasConcept C43759708 @default.
• W2035794173 hasConcept C552990157 @default.
• W2035794173 hasConcept C55493867 @default.
• W2035794173 hasConcept C82381507 @default.
• W2035794173 hasConcept C86803240 @default.
• W2035794173 hasConcept C95444343 @default.
• W2035794173 hasConcept C98424977 @default.
• W2035794173 hasConceptScore W2035794173C105696609 @default.
• W2035794173 hasConceptScore W2035794173C153911025 @default.
• W2035794173 hasConceptScore W2035794173C182979987 @default.
• W2035794173 hasConceptScore W2035794173C185592680 @default.
• W2035794173 hasConceptScore W2035794173C190283241 @default.
• W2035794173 hasConceptScore W2035794173C28859421 @default.
• W2035794173 hasConceptScore W2035794173C29311851 @default.
• W2035794173 hasConceptScore W2035794173C29537977 @default.
• W2035794173 hasConceptScore W2035794173C31573885 @default.
• W2035794173 hasConceptScore W2035794173C43759708 @default.
• W2035794173 hasConceptScore W2035794173C552990157 @default.

• next