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- W2035799236 abstract "The advancing antimicrobial drug resistance in common bacterial pathogens, along with the relative shortage of new antibacterial agents, call for the re-evaluation of available therapeutic options. Fosfomycin is an established treatment option for uncomplicated urinary tract infections. Here we review and evaluate the main pharmacokinetic and pharmacodynamic parameters of intravenously administered fosfomycin with regard to its use for systemic infections. Fosfomycin is a relatively small, hydrophilic agent with almost negligible serum protein binding. It is excreted unchanged in urine, achieving high concentrations for a prolonged period. Fosfomycin has good distribution into tissues, achieving clinically relevant concentrations in sites such as serum, soft tissue, lungs, bone, cerebrospinal fluid and heart valves. Fosfomycin has shown antimicrobial activity against biofilms, particularly in combination with fluoroquinolones. It also exerts immunomodulatory effects, mainly on lymphocyte and neutrophil function. Potentially useful properties of fosfomycin regarding its use in combination regimens include reduction in the expression of certain penicillin-binding proteins and attenuation of nephrotoxicity caused by several antimicrobial agents. In conclusion, the pharmacokinetic and pharmacodynamic properties of fosfomycin do not preclude its use for various types of systemic infections and suggest further research on relevant clinical applications of this agent." @default.
- W2035799236 created "2016-06-24" @default.
- W2035799236 creator A5010312876 @default.
- W2035799236 creator A5034055658 @default.
- W2035799236 creator A5047582800 @default.
- W2035799236 creator A5066664805 @default.
- W2035799236 date "2009-12-01" @default.
- W2035799236 modified "2023-10-06" @default.
- W2035799236 title "Clinical significance of the pharmacokinetic and pharmacodynamic characteristics of fosfomycin for the treatment of patients with systemic infections" @default.
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- W2035799236 doi "https://doi.org/10.1016/j.ijantimicag.2009.08.013" @default.
- W2035799236 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19828298" @default.
- W2035799236 hasPublicationYear "2009" @default.
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