FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035803605> ?p ?o ?g. }

• W2035803605 abstract "We have recovered one bla(NDM-1)-harboring bacterial strain, designated as XM1570, from a sputum sample obtained from a fatal case of pneumonia in China.Biochemical profiling, 16S rRNA sequencing and antimicrobial susceptibility testing were performed. Conjugation experiments were conducted to determine transmissibility of resistance. Pulsed-field gel electrophoresis and whole genome sequencing were performed to identify strain-specific features.The isolate XM1570 was identified as Acinetobacter calcoaceticus. Whole genome sequencing identified two plasmids, pXM1 and pXM2. Comparative analysis showed >99% similarity between XM1570 and A. calcoaceticus PHEA-2. Plasmid pXM1 carried the carbapenemase gene bla(NDM-1) and displayed high homology with previously described plasmids isolated from different Acinetobacter spp., which were collected from human or livestock distributed in China and worldwide. The bla(NDM-1) gene was located on this conjugative plasmid in a transposon-like region flanked by two copies of the insertion sequence ISAba125; and resistance to all tested β-lactams was observed. Transferability of resistance from pXM1 to the transconjugants was identified. Plasmid pXM2 had an insertion sequence ISAba125 and a -35 region of the bla NDM-1 gene promoter but the bla NDM-1 gene was not present. A chromosomally located carbapenemase-encoding gene bla OXA-75 was detected; however, this gene was interrupted by an insertion sequence ISAba22 belonging to IS3 family.Location of bla(NDM-1) on different self-transmissible plasmids could facilitate geographically broad dissemination and host range expansion of the bla(NDM-1) gene via horizontal gene transfer. Our findings of this normally environmental species A. calcoaceticus XM1570 further underline the significant clinical challenge and the essential need for surveillance including molecular methods and plasmid analyses." @default.
• W2035803605 created "2016-06-24" @default.
• W2035803605 creator A5030967805 @default.
• W2035803605 creator A5046552608 @default.
• W2035803605 creator A5051324730 @default.
• W2035803605 creator A5056101043 @default.
• W2035803605 creator A5057500273 @default.
• W2035803605 creator A5066102428 @default.
• W2035803605 creator A5071458554 @default.
• W2035803605 creator A5072834448 @default.
• W2035803605 creator A5083228843 @default.
• W2035803605 creator A5089738575 @default.
• W2035803605 date "2015-03-18" @default.
• W2035803605 modified "2023-10-16" @default.
• W2035803605 title "Acinetobacter calcoaceticus from a fatal case of pneumonia harboring blaNDM-1 on a widely distributed plasmid" @default.
• W2035803605 cites W1517672332 @default.
• W2035803605 cites W1881047311 @default.
• W2035803605 cites W1938922303 @default.
• W2035803605 cites W1958427350 @default.
• W2035803605 cites W1965498852 @default.
• W2035803605 cites W1967487041 @default.
• W2035803605 cites W1983888098 @default.
• W2035803605 cites W2008750362 @default.
• W2035803605 cites W2014239394 @default.
• W2035803605 cites W2014477899 @default.
• W2035803605 cites W2028031087 @default.
• W2035803605 cites W2032454717 @default.
• W2035803605 cites W2033114587 @default.
• W2035803605 cites W2041257508 @default.
• W2035803605 cites W2043789968 @default.
• W2035803605 cites W2049491797 @default.
• W2035803605 cites W2057665284 @default.
• W2035803605 cites W2065337857 @default.
• W2035803605 cites W2065410910 @default.
• W2035803605 cites W2074663598 @default.
• W2035803605 cites W2080607963 @default.
• W2035803605 cites W2108140165 @default.
• W2035803605 cites W2111211467 @default.
• W2035803605 cites W2111426588 @default.
• W2035803605 cites W2112647163 @default.
• W2035803605 cites W2116540792 @default.
• W2035803605 cites W2118995840 @default.
• W2035803605 cites W2123677996 @default.
• W2035803605 cites W2126539156 @default.
• W2035803605 cites W2129889303 @default.
• W2035803605 cites W2131046586 @default.
• W2035803605 cites W2134519766 @default.
• W2035803605 cites W2136437790 @default.
• W2035803605 cites W2136653513 @default.
• W2035803605 cites W2140872496 @default.
• W2035803605 cites W2151017866 @default.
• W2035803605 cites W2151299416 @default.
• W2035803605 cites W2151923665 @default.
• W2035803605 cites W2152092848 @default.
• W2035803605 cites W2159435953 @default.
• W2035803605 cites W2165823261 @default.
• W2035803605 cites W2166455604 @default.
• W2035803605 cites W2172130936 @default.
• W2035803605 cites W2414736433 @default.
• W2035803605 doi "https://doi.org/10.1186/s12879-015-0870-7" @default.
• W2035803605 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4373515" @default.
• W2035803605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25881070" @default.
• W2035803605 hasPublicationYear "2015" @default.
• W2035803605 type Work @default.
• W2035803605 sameAs 2035803605 @default.
• W2035803605 citedByCount "17" @default.
• W2035803605 countsByYear W20358036052015 @default.
• W2035803605 countsByYear W20358036052016 @default.
• W2035803605 countsByYear W20358036052017 @default.
• W2035803605 countsByYear W20358036052019 @default.
• W2035803605 countsByYear W20358036052020 @default.
• W2035803605 countsByYear W20358036052021 @default.
• W2035803605 countsByYear W20358036052022 @default.
• W2035803605 countsByYear W20358036052023 @default.
• W2035803605 crossrefType "journal-article" @default.
• W2035803605 hasAuthorship W2035803605A5030967805 @default.
• W2035803605 hasAuthorship W2035803605A5046552608 @default.
• W2035803605 hasAuthorship W2035803605A5051324730 @default.
• W2035803605 hasAuthorship W2035803605A5056101043 @default.
• W2035803605 hasAuthorship W2035803605A5057500273 @default.
• W2035803605 hasAuthorship W2035803605A5066102428 @default.
• W2035803605 hasAuthorship W2035803605A5071458554 @default.
• W2035803605 hasAuthorship W2035803605A5072834448 @default.
• W2035803605 hasAuthorship W2035803605A5083228843 @default.
• W2035803605 hasAuthorship W2035803605A5089738575 @default.
• W2035803605 hasBestOaLocation W20358036051 @default.
• W2035803605 hasConcept C104317684 @default.
• W2035803605 hasConcept C141231307 @default.
• W2035803605 hasConcept C157887575 @default.
• W2035803605 hasConcept C22744801 @default.
• W2035803605 hasConcept C24432333 @default.
• W2035803605 hasConcept C2775859738 @default.
• W2035803605 hasConcept C2778523567 @default.
• W2035803605 hasConcept C4918238 @default.
• W2035803605 hasConcept C523546767 @default.
• W2035803605 hasConcept C54355233 @default.
• W2035803605 hasConcept C61053724 @default.
• W2035803605 hasConcept C86803240 @default.
• W2035803605 hasConcept C89423630 @default.
• W2035803605 hasConcept C92938381 @default.

• next