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- W2035815478 abstract "Summary VDJ and VJ rearrangements, expression of RAG ‐1, Tdt and VpreB, and the presence of signal joint circles ( SJC ) were used to identify sites of B‐cell lymphogenesis. VDJ , VλJλ but not VκJκ rearrangements or SJC were recovered from yolk sac ( YS ) at 20 days of gestation ( DG ) along with strong expression of VpreB and RAG ‐1 but weak Tdt expression. VλJλ rearrangements but not VκJκ rearrangements were recovered from fetal liver at 30–50 DG . SJC were pronounced in bone marrow at 95 DG where VκJκ rearrangements were first recovered. The VλJλ rearrangements recovered at 20–50 DG used some of the same Vλ and Jλ segments seen in older fetuses and adult animals. Hence the textbook paradigm for the order of light‐chain rearrangement does not apply to swine. Consistent with weak Tdt expression in early sites of lymphogenesis, N‐region additions in VDJ rearrangements were more frequent at 95 DG . Junctional diversity in VλJλ rearrangement was limited at all stages of development. There was little evidence for B‐cell lymphogenesis in the ileal Peyer's patches. The widespread recovery of VpreB transcripts in whole, non‐lymphoid tissue was unexpected as was its recovery from bone marrow and peripheral blood monocytes. Based on recovery of SJC , B‐cell lymphogenesis continues for at least 5 weeks postpartum." @default.
- W2035815478 created "2016-06-24" @default.
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- W2035815478 creator A5069985236 @default.
- W2035815478 creator A5089174248 @default.
- W2035815478 date "2012-09-04" @default.
- W2035815478 modified "2023-10-02" @default.
- W2035815478 title "Antibody repertoire development in fetal and neonatal piglets. XXII. λ rearrangement precedes κ rearrangement during B-cell lymphogenesis in swine" @default.
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- W2035815478 doi "https://doi.org/10.1111/j.1365-2567.2012.03615.x" @default.
- W2035815478 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3461396" @default.