Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035828859> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2035828859 endingPage "84" @default.
- W2035828859 startingPage "71" @default.
- W2035828859 abstract "High-performance liquid chromatographic (HPLC) methods using ultraviolet (UV) detection have been developed for the assay of the antibiotic imipenem (N-formimidoyl thienamycin) in human plasma and urine. A reversed-phase analytical column is employed in the plasma assay method and a cation-exchange column is used in the urine assay method. Both methods use borate buffer in the mobile phase. The method of preparation of human fluid samples for HPLC injection has been optimized with respect to the stability of imipenem in aqueous buffers, in morpholine buffer--ethylene glycol stabilizer, and in urine and plasma. Preparation of the samples before injection into the HPLC systems involves deproteination/filtration of the plasma/urine samples. The open lactam metabolite and the coadministered dehydropeptidase inhibitor, cilastatin sodium, do not interfere with the 313-nm detection of imipenem in either the plasma or the urine assay. Thienamycin, the precursor of imipenem and an impurity in imipenem formulations, is separated from the drug using both of these methods. Concentrations generated from the HPLC analysis of plasma and urine samples from two healthy volunteers compare favorably with results using a microbiological assay method. Correlation of the two methods gives r greater than or equal to 0.990 for both fluids." @default.
- W2035828859 created "2016-06-24" @default.
- W2035828859 creator A5021502082 @default.
- W2035828859 creator A5032921714 @default.
- W2035828859 creator A5089316609 @default.
- W2035828859 creator A5090100336 @default.
- W2035828859 date "1984-01-01" @default.
- W2035828859 modified "2023-09-27" @default.
- W2035828859 title "Determination of imipenem (N-formimidoyl thienamycin) in human plasma and urine by high-performance liquid chromatography, comparison with microbiological methodology and stability" @default.
- W2035828859 cites W1986401742 @default.
- W2035828859 cites W2034545699 @default.
- W2035828859 cites W2036739472 @default.
- W2035828859 cites W2077045941 @default.
- W2035828859 cites W2087378988 @default.
- W2035828859 cites W2094995138 @default.
- W2035828859 cites W2111559579 @default.
- W2035828859 cites W2150326587 @default.
- W2035828859 cites W2313660939 @default.
- W2035828859 doi "https://doi.org/10.1016/0378-4347(84)80069-9" @default.
- W2035828859 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6389581" @default.
- W2035828859 hasPublicationYear "1984" @default.
- W2035828859 type Work @default.
- W2035828859 sameAs 2035828859 @default.
- W2035828859 citedByCount "57" @default.
- W2035828859 countsByYear W20358288592012 @default.
- W2035828859 countsByYear W20358288592013 @default.
- W2035828859 countsByYear W20358288592014 @default.
- W2035828859 countsByYear W20358288592015 @default.
- W2035828859 countsByYear W20358288592020 @default.
- W2035828859 countsByYear W20358288592022 @default.
- W2035828859 crossrefType "journal-article" @default.
- W2035828859 hasAuthorship W2035828859A5021502082 @default.
- W2035828859 hasAuthorship W2035828859A5032921714 @default.
- W2035828859 hasAuthorship W2035828859A5089316609 @default.
- W2035828859 hasAuthorship W2035828859A5090100336 @default.
- W2035828859 hasConcept C179998833 @default.
- W2035828859 hasConcept C185592680 @default.
- W2035828859 hasConcept C2777437143 @default.
- W2035828859 hasConcept C2777477808 @default.
- W2035828859 hasConcept C2777870638 @default.
- W2035828859 hasConcept C2779631663 @default.
- W2035828859 hasConcept C2780026642 @default.
- W2035828859 hasConcept C43617362 @default.
- W2035828859 hasConcept C501593827 @default.
- W2035828859 hasConcept C55493867 @default.
- W2035828859 hasConcept C94665300 @default.
- W2035828859 hasConceptScore W2035828859C179998833 @default.
- W2035828859 hasConceptScore W2035828859C185592680 @default.
- W2035828859 hasConceptScore W2035828859C2777437143 @default.
- W2035828859 hasConceptScore W2035828859C2777477808 @default.
- W2035828859 hasConceptScore W2035828859C2777870638 @default.
- W2035828859 hasConceptScore W2035828859C2779631663 @default.
- W2035828859 hasConceptScore W2035828859C2780026642 @default.
- W2035828859 hasConceptScore W2035828859C43617362 @default.
- W2035828859 hasConceptScore W2035828859C501593827 @default.
- W2035828859 hasConceptScore W2035828859C55493867 @default.
- W2035828859 hasConceptScore W2035828859C94665300 @default.
- W2035828859 hasLocation W20358288591 @default.
- W2035828859 hasLocation W20358288592 @default.
- W2035828859 hasOpenAccess W2035828859 @default.
- W2035828859 hasPrimaryLocation W20358288591 @default.
- W2035828859 hasRelatedWork W118183763 @default.
- W2035828859 hasRelatedWork W1970888742 @default.
- W2035828859 hasRelatedWork W1999972235 @default.
- W2035828859 hasRelatedWork W2008727242 @default.
- W2035828859 hasRelatedWork W2035747744 @default.
- W2035828859 hasRelatedWork W2059821482 @default.
- W2035828859 hasRelatedWork W2107750257 @default.
- W2035828859 hasRelatedWork W2406364491 @default.
- W2035828859 hasRelatedWork W2493600594 @default.
- W2035828859 hasRelatedWork W62838962 @default.
- W2035828859 hasVolume "310" @default.
- W2035828859 isParatext "false" @default.
- W2035828859 isRetracted "false" @default.
- W2035828859 magId "2035828859" @default.
- W2035828859 workType "article" @default.