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- W2035839201 abstract "A rapid and high-yield synthesis of methylmalonyl coenzyme A is reported. The two-step procedure involves preparation of the thiophenyl ester of methylmalonic acid using dicyclohexylcarbodiimide as a condensing agent, followed by transesterification with coenzyme A, to yield methylmalonyl coenzyme A in 80% overall yield. Inclusion of an additional step, methylation of malonic acid with iodomethane, affords the opportunity for introducing a stable or radioactive isotope into the product. This method should be applicable for the syntheses of other coenzyme A esters that are of biochemical interest such as succinyl coenzyme A." @default.
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- W2035839201 date "1993-10-01" @default.
- W2035839201 modified "2023-10-18" @default.
- W2035839201 title "A Rapid Method for the Synthesis of Methylmalonyl-Coenzyme A and Other CoA-Esters" @default.
- W2035839201 doi "https://doi.org/10.1006/abio.1993.1494" @default.
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