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- W2035841034 abstract "BackgroundPolybrominated diphenyl ethers (PBDEs) are capable of disrupting thyroid hormone homeostasis. PBDE-47 (2,2′,4,4′-tetrabromodiphenyl ether) is one of the most abundant congeners found in human breast adipose tissue and maternal milk samples.ObjectivesWe evaluated the effects of developmental exposure to low doses of PBDE-47 on the female reproductive system.MethodsPregnant Wistar rats were administered vehicle (peanut oil) or PBDE-47 [140 or 700 μg/kg body weight (bw)] on gestation day (GD) 6, or 5 mg 6-n-propyl-2-thiouracil (PTU)/L in the drinking water from GD7 through postnatal day (PND) 21.ResultsIn female offspring sacrificed on PND38, there was a significant decrease in ovarian weight after exposure to PTU or 140 μg/kg PBDE-47. Alterations in folliculogenesis were apparent: we observed a decrease in tertiary follicles and serum estradiol concentrations in the offspring exposed to either PTU or 700 μg/kg PBDE-47. PTU exposure also resulted in a decrease in primordial follicles. On PND100, persistent effects on the thyroid glands included histologic and morphometric changes after exposure to either PTU or PBDE-47. No relevant changes in reproductive indices were observed after mating the exposed F1 females with nontreated males.ConclusionsAdministration of PBDE-47 at doses relevant to human exposure led to changes in the rat female reproductive system and thyroid gland." @default.
- W2035841034 created "2016-06-24" @default.
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- W2035841034 date "2008-03-01" @default.
- W2035841034 modified "2023-10-18" @default.
- W2035841034 title "<i>In Utero</i> and Lactational Exposures to Low Doses of Polybrominated Diphenyl Ether-47 Alter the Reproductive System and Thyroid Gland of Female Rat Offspring" @default.
- W2035841034 cites W1968614586 @default.
- W2035841034 cites W1969444271 @default.
- W2035841034 cites W1971425761 @default.
- W2035841034 cites W1974690510 @default.
- W2035841034 cites W1977337002 @default.
- W2035841034 cites W1982071978 @default.
- W2035841034 cites W1984747222 @default.
- W2035841034 cites W1987227107 @default.
- W2035841034 cites W1995028694 @default.
- W2035841034 cites W2005416593 @default.
- W2035841034 cites W2010773835 @default.
- W2035841034 cites W2014465432 @default.
- W2035841034 cites W2019007589 @default.
- W2035841034 cites W2020213679 @default.
- W2035841034 cites W2024320576 @default.
- W2035841034 cites W2025175568 @default.
- W2035841034 cites W2041186805 @default.
- W2035841034 cites W2043228024 @default.
- W2035841034 cites W2043482823 @default.
- W2035841034 cites W2046752722 @default.
- W2035841034 cites W2051242813 @default.
- W2035841034 cites W2051934006 @default.
- W2035841034 cites W2056128228 @default.
- W2035841034 cites W2057881071 @default.
- W2035841034 cites W2059530652 @default.
- W2035841034 cites W2060990597 @default.
- W2035841034 cites W2062257143 @default.
- W2035841034 cites W2065733758 @default.
- W2035841034 cites W2066646121 @default.
- W2035841034 cites W2078199102 @default.
- W2035841034 cites W2081225531 @default.
- W2035841034 cites W2087666593 @default.
- W2035841034 cites W2090559249 @default.
- W2035841034 cites W2092337736 @default.
- W2035841034 cites W2093252285 @default.
- W2035841034 cites W2093753433 @default.
- W2035841034 cites W2099964971 @default.
- W2035841034 cites W2101676483 @default.
- W2035841034 cites W2103282761 @default.
- W2035841034 cites W2104125840 @default.
- W2035841034 cites W2107608797 @default.
- W2035841034 cites W2109561093 @default.
- W2035841034 cites W2110611073 @default.
- W2035841034 cites W2112480342 @default.
- W2035841034 cites W2112496271 @default.
- W2035841034 cites W2114041290 @default.
- W2035841034 cites W2116247329 @default.
- W2035841034 cites W2120002056 @default.
- W2035841034 cites W2125387524 @default.
- W2035841034 cites W2139644773 @default.
- W2035841034 cites W2140355945 @default.
- W2035841034 cites W2142038201 @default.
- W2035841034 cites W2145516138 @default.
- W2035841034 cites W2145545413 @default.
- W2035841034 cites W2145931016 @default.
- W2035841034 cites W2146354194 @default.
- W2035841034 cites W2158120784 @default.
- W2035841034 cites W4296979145 @default.
- W2035841034 doi "https://doi.org/10.1289/ehp.10536" @default.
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