FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035856795> ?p ?o ?g. }

• W2035856795 endingPage "3093" @default.
• W2035856795 startingPage "3087" @default.
• W2035856795 abstract "Osteoporosis causes fractures that lead to reduction in the quality of life and it is one of the most prevalent diseases as it affects approximately 10% of the population. One of the important features of osteoporosis is osteopenia. However, its etiology is not fully elucidated. Dok-1 and Dok-2 are adaptor proteins acting downstream of protein tyrosine kinases that are mainly expressed in the cells of hematopoietic lineage. Although these proteins negatively regulate immune system, their roles in bone metabolism are not understood. Here, we analyzed the effects of Dok-1 and Dok-2 double-deficiency on bone. Dok-1/2 deficiency reduced the levels of trabecular and cortical bone mass compared to wildtype. In addition, Dok-1/2 deficiency increased periosteal perimeters and endosteal perimeters of the mid shaft of long bones. Histomorphometric analysis of the bone parameters indicated that Dok-1/2 deficiency did not significantly alter the levels of bone formation parameters including mineralizing surface/bone surface (MS/BS), mineral apposition rate (MAR) and bone formation rate (BFR). In contrast, Dok-1/2 deficiency enhanced the levels of bone resorption parameters including osteoclast number (N.Oc/BS) and osteoclast surface (Oc.S/BS). Analyses of individual osteoclastic activity indicated that Dok-1/2 deficiency enhanced pit formation. Systemically, Dok-1/2 deficiency increased the levels of urinary deoxypyridinoline (Dpyr). Search for the target point of the Dok-1/2 deficiency effects on osteoclasts identified that the mutation enhanced sensitivity of osteoclast precursors to macrophage colony-stimulating factor. These data revealed that Dok-1 and Dok-2 deficiency induces osteopenia by activation of osteoclasts." @default.
• W2035856795 created "2016-06-24" @default.
• W2035856795 creator A5009692222 @default.
• W2035856795 creator A5017420023 @default.
• W2035856795 creator A5017928696 @default.
• W2035856795 creator A5018325327 @default.
• W2035856795 creator A5041321400 @default.
• W2035856795 creator A5054624652 @default.
• W2035856795 creator A5055639031 @default.
• W2035856795 creator A5061796459 @default.
• W2035856795 creator A5070886458 @default.
• W2035856795 creator A5079818669 @default.
• W2035856795 date "2011-09-23" @default.
• W2035856795 modified "2023-10-14" @default.
• W2035856795 title "Dok-1 and Dok-2 deficiency induces osteopenia via activation of osteoclasts" @default.
• W2035856795 cites W1987052942 @default.
• W2035856795 cites W1989343687 @default.
• W2035856795 cites W2007458155 @default.
• W2035856795 cites W2011388217 @default.
• W2035856795 cites W2018218393 @default.
• W2035856795 cites W2025672294 @default.
• W2035856795 cites W2025972280 @default.
• W2035856795 cites W2043033796 @default.
• W2035856795 cites W2058402228 @default.
• W2035856795 cites W2069807028 @default.
• W2035856795 cites W2078419961 @default.
• W2035856795 cites W2080361561 @default.
• W2035856795 cites W2082176941 @default.
• W2035856795 cites W2093670935 @default.
• W2035856795 cites W2097137746 @default.
• W2035856795 cites W2097863504 @default.
• W2035856795 cites W2106774501 @default.
• W2035856795 cites W2113697838 @default.
• W2035856795 cites W2114700025 @default.
• W2035856795 cites W2115967760 @default.
• W2035856795 cites W2127978145 @default.
• W2035856795 cites W2128686747 @default.
• W2035856795 cites W2132408993 @default.
• W2035856795 cites W2152005560 @default.
• W2035856795 cites W2152847526 @default.
• W2035856795 cites W2153923367 @default.
• W2035856795 cites W2154230667 @default.
• W2035856795 cites W2157979607 @default.
• W2035856795 cites W2162812744 @default.
• W2035856795 cites W2166990713 @default.
• W2035856795 cites W2168609932 @default.
• W2035856795 cites W2169184588 @default.
• W2035856795 cites W4238012100 @default.
• W2035856795 cites W4974559 @default.
• W2035856795 cites W86656726 @default.
• W2035856795 doi "https://doi.org/10.1002/jcp.22909" @default.
• W2035856795 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21732353" @default.
• W2035856795 hasPublicationYear "2011" @default.
• W2035856795 type Work @default.
• W2035856795 sameAs 2035856795 @default.
• W2035856795 citedByCount "12" @default.
• W2035856795 countsByYear W20358567952013 @default.
• W2035856795 countsByYear W20358567952014 @default.
• W2035856795 countsByYear W20358567952015 @default.
• W2035856795 countsByYear W20358567952017 @default.
• W2035856795 countsByYear W20358567952018 @default.
• W2035856795 countsByYear W20358567952019 @default.
• W2035856795 crossrefType "journal-article" @default.
• W2035856795 hasAuthorship W2035856795A5009692222 @default.
• W2035856795 hasAuthorship W2035856795A5017420023 @default.
• W2035856795 hasAuthorship W2035856795A5017928696 @default.
• W2035856795 hasAuthorship W2035856795A5018325327 @default.
• W2035856795 hasAuthorship W2035856795A5041321400 @default.
• W2035856795 hasAuthorship W2035856795A5054624652 @default.
• W2035856795 hasAuthorship W2035856795A5055639031 @default.
• W2035856795 hasAuthorship W2035856795A5061796459 @default.
• W2035856795 hasAuthorship W2035856795A5070886458 @default.
• W2035856795 hasAuthorship W2035856795A5079818669 @default.
• W2035856795 hasConcept C126322002 @default.
• W2035856795 hasConcept C131075544 @default.
• W2035856795 hasConcept C134018914 @default.
• W2035856795 hasConcept C160160445 @default.
• W2035856795 hasConcept C170033053 @default.
• W2035856795 hasConcept C170493617 @default.
• W2035856795 hasConcept C181199279 @default.
• W2035856795 hasConcept C185592680 @default.
• W2035856795 hasConcept C2776033226 @default.
• W2035856795 hasConcept C2776541429 @default.
• W2035856795 hasConcept C2776886416 @default.
• W2035856795 hasConcept C2777083390 @default.
• W2035856795 hasConcept C2780787237 @default.
• W2035856795 hasConcept C55493867 @default.
• W2035856795 hasConcept C673006 @default.
• W2035856795 hasConcept C71924100 @default.
• W2035856795 hasConceptScore W2035856795C126322002 @default.
• W2035856795 hasConceptScore W2035856795C131075544 @default.
• W2035856795 hasConceptScore W2035856795C134018914 @default.
• W2035856795 hasConceptScore W2035856795C160160445 @default.
• W2035856795 hasConceptScore W2035856795C170033053 @default.
• W2035856795 hasConceptScore W2035856795C170493617 @default.
• W2035856795 hasConceptScore W2035856795C181199279 @default.
• W2035856795 hasConceptScore W2035856795C185592680 @default.
• W2035856795 hasConceptScore W2035856795C2776033226 @default.

• next