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- W2035863172 abstract "I should like to comment concerning the paper by Drs. Janet F. Bacon and Gillian M. Shenfield (2 February p. 293). They have suggested that the decreased blood levels of steroids associated with the coadministration of rifampicin and oral contraceptives is due to an interruption in the entero-hepatic circulation of steroids. However administration of rifampicin causes proliferation of the smooth endoplasmic reticulum of the hepatocyte and induces drug-metabolizing enzyme systems in the liver (the cytochrome P450 content of the liver is increased). Steroid hormones are eliminated mainly by metabolism in the liver. Hepatic clearance (or rate of removal from the body) of steroid hormones is thus increased when these are given in conjunction with enzyme-inducing agents such as rifampicin phenobarbital glurethimide and phenytoin and the increase results in decreased plasma levels of the drug. This methanism of drug interaction is a common one and may explain the reported results. (Authors modified)" @default.
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- W2035863172 date "1980-05-17" @default.
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- W2035863172 title "Interaction between oral contraceptives and other drugs." @default.
- W2035863172 cites W1976696095 @default.
- W2035863172 doi "https://doi.org/10.1136/bmj.280.6225.1230-a" @default.
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