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• W2035876908 abstract "<i>Objective:</i> To investigate whether the mechanism of a combined surfactant and inhaled nitric oxide (iNO) in improvement of oxygenation and mitigation of lung injury is associated with suppression of nuclear transcription factor kappa B (NF-ĸB) in the lung tissue of ventilated rabbits with meconium aspiration. <i>Methods:</i> Adult rabbits (weight 2.0–3.5 kg, n = 33) were anesthetized, intratracheally received human meconium, and were subjected to pressure support ventilation for 30–60 min to induce hypoxemic respiratory failure and lung injury. They were then treated for 6 h in groups: control animals; rabbits receiving iNO; animals receiving surfactant (100 mg/kg), and rabbits receiving both iNO and surfactant. iNO was delivered continuously by mass flow controller in sequence at 1, 10, 20, and 40 ppm each for 60 min at 30-min intervals. <i>Results:</i> Improvement in oxygenation and lung mechanics was found in the animals receiving both iNO and surfactant, associated with a marked response to iNO at 10 and 20 ppm (p < 0.05), a significantly higher ratio of disaturated phosphatidylcholine to total proteins, a lower surface tension of phospholipids from bronchoalveolar lavage fluid, a lower wet-to-dry lung weight ratio and lower lung injury scores, and better alveolar aeration. The iNO- and surfactant-treated groups had only transient or moderate-to-intermediate improvement in the associated parameters. The expression of NF-ĸB in lung tissue was enhanced in the control group, attenuated in the groups treated with either iNO or surfactant, and significantly suppressed in the group receiving both iNO and surfactant. <i>Conclusion:</i> Improvements of lung mechanics and gas exchange and mitigation of lung injury by the combined surfactant and iNO are related to suppression of NF-ĸB expression in lung tissue of ventilated rabbits with hypoxemic respiratory failure." @default.
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• W2035876908 date "2005-01-01" @default.
• W2035876908 modified "2023-10-18" @default.
• W2035876908 title "Mitigation of Meconium-Induced Lung Injury by Surfactant and Inhaled Nitric Oxide Is Associated with Suppression of Nuclear Transcription Factor Kappa B" @default.
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• W2035876908 doi "https://doi.org/10.1159/000081266" @default.
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