FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035879073> ?p ?o ?g. }

• W2035879073 endingPage "443" @default.
• W2035879073 startingPage "437" @default.
• W2035879073 abstract "Sea anemones use an arsenal of peptide neurotoxins accumulated in special stinging cells (nematocytes) for defense and predation. Intriguingly, genomic analysis of Nematostella vectensis revealed only a single toxin, Nv1 (N. vectensis toxin 1), encoded by multiple extremely conserved genes. We examined the toxic potential of Nv1 and whether it is produced by the three developmental stages (embryo, planula, and polyp) of Nematostella. Nv1 was expressed in recombinant form and, similarly to Type I sea anemone toxins, inhibited the inactivation of voltage-gated sodium channels. However, in contrast to the other toxins, Nv1 revealed high specificity for insect over mammalian voltage-gated sodium channels. Transcript analysis indicated that multiple Nv1 loci are transcribed at all developmental stages of N. vectensis, whereas splicing of these transcripts is restricted to the polyp stage. This finding suggests that regulation of Nv1 synthesis is posttranscriptional and that the embryo and planula stages do not produce the Nv1 toxin. This rare phenomenon of intron retention at the early developmental stages is intriguing and raises the question as to the mechanism enabling such differential expression in sea anemones." @default.
• W2035879073 created "2016-06-24" @default.
• W2035879073 creator A5045631776 @default.
• W2035879073 creator A5051104404 @default.
• W2035879073 creator A5053799789 @default.
• W2035879073 creator A5054870832 @default.
• W2035879073 creator A5069782760 @default.
• W2035879073 creator A5075107978 @default.
• W2035879073 creator A5076558659 @default.
• W2035879073 creator A5088980956 @default.
• W2035879073 date "2008-07-01" @default.
• W2035879073 modified "2023-10-12" @default.
• W2035879073 title "Intron Retention as a Posttranscriptional Regulatory Mechanism of Neurotoxin Expression at Early Life Stages of the Starlet Anemone Nematostella vectensis" @default.
• W2035879073 cites W1511576878 @default.
• W2035879073 cites W1536677411 @default.
• W2035879073 cites W1604700682 @default.
• W2035879073 cites W1781227295 @default.
• W2035879073 cites W1971968167 @default.
• W2035879073 cites W1972956491 @default.
• W2035879073 cites W1976099847 @default.
• W2035879073 cites W1983152429 @default.
• W2035879073 cites W2005214845 @default.
• W2035879073 cites W2006368030 @default.
• W2035879073 cites W2006780579 @default.
• W2035879073 cites W2011186542 @default.
• W2035879073 cites W2016442704 @default.
• W2035879073 cites W2017181203 @default.
• W2035879073 cites W2019319438 @default.
• W2035879073 cites W2027343372 @default.
• W2035879073 cites W2052212640 @default.
• W2035879073 cites W2060809301 @default.
• W2035879073 cites W2063318299 @default.
• W2035879073 cites W2067558229 @default.
• W2035879073 cites W2078277630 @default.
• W2035879073 cites W2085385454 @default.
• W2035879073 cites W2089021618 @default.
• W2035879073 cites W2089357209 @default.
• W2035879073 cites W2094301176 @default.
• W2035879073 cites W2106970453 @default.
• W2035879073 cites W2108656422 @default.
• W2035879073 cites W2121064423 @default.
• W2035879073 cites W2146775981 @default.
• W2035879073 cites W2151061073 @default.
• W2035879073 cites W2152323039 @default.
• W2035879073 cites W2158247578 @default.
• W2035879073 doi "https://doi.org/10.1016/j.jmb.2008.05.011" @default.
• W2035879073 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18538344" @default.
• W2035879073 hasPublicationYear "2008" @default.
• W2035879073 type Work @default.
• W2035879073 sameAs 2035879073 @default.
• W2035879073 citedByCount "41" @default.
• W2035879073 countsByYear W20358790732012 @default.
• W2035879073 countsByYear W20358790732013 @default.
• W2035879073 countsByYear W20358790732014 @default.
• W2035879073 countsByYear W20358790732015 @default.
• W2035879073 countsByYear W20358790732016 @default.
• W2035879073 countsByYear W20358790732017 @default.
• W2035879073 countsByYear W20358790732018 @default.
• W2035879073 countsByYear W20358790732019 @default.
• W2035879073 countsByYear W20358790732020 @default.
• W2035879073 countsByYear W20358790732021 @default.
• W2035879073 countsByYear W20358790732022 @default.
• W2035879073 countsByYear W20358790732023 @default.
• W2035879073 crossrefType "journal-article" @default.
• W2035879073 hasAuthorship W2035879073A5045631776 @default.
• W2035879073 hasAuthorship W2035879073A5051104404 @default.
• W2035879073 hasAuthorship W2035879073A5053799789 @default.
• W2035879073 hasAuthorship W2035879073A5054870832 @default.
• W2035879073 hasAuthorship W2035879073A5069782760 @default.
• W2035879073 hasAuthorship W2035879073A5075107978 @default.
• W2035879073 hasAuthorship W2035879073A5076558659 @default.
• W2035879073 hasAuthorship W2035879073A5088980956 @default.
• W2035879073 hasConcept C104317684 @default.
• W2035879073 hasConcept C143020374 @default.
• W2035879073 hasConcept C183074962 @default.
• W2035879073 hasConcept C18903297 @default.
• W2035879073 hasConcept C2775939778 @default.
• W2035879073 hasConcept C2778089062 @default.
• W2035879073 hasConcept C2779356992 @default.
• W2035879073 hasConcept C32229687 @default.
• W2035879073 hasConcept C34781881 @default.
• W2035879073 hasConcept C54355233 @default.
• W2035879073 hasConcept C59822182 @default.
• W2035879073 hasConcept C86803240 @default.
• W2035879073 hasConcept C94671646 @default.
• W2035879073 hasConcept C95444343 @default.
• W2035879073 hasConceptScore W2035879073C104317684 @default.
• W2035879073 hasConceptScore W2035879073C143020374 @default.
• W2035879073 hasConceptScore W2035879073C183074962 @default.
• W2035879073 hasConceptScore W2035879073C18903297 @default.
• W2035879073 hasConceptScore W2035879073C2775939778 @default.
• W2035879073 hasConceptScore W2035879073C2778089062 @default.
• W2035879073 hasConceptScore W2035879073C2779356992 @default.
• W2035879073 hasConceptScore W2035879073C32229687 @default.
• W2035879073 hasConceptScore W2035879073C34781881 @default.
• W2035879073 hasConceptScore W2035879073C54355233 @default.
• W2035879073 hasConceptScore W2035879073C59822182 @default.
• W2035879073 hasConceptScore W2035879073C86803240 @default.

• next