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- W2035880334 abstract "The article by S. H. Buck and T. F. Burks (TIPS 4, 84-87) is a good overview of recent investigations and will probably have a stimulating effect on further research. Therefore, it is necessary to clarify some points to avoid confusion or misinterpretation. This is the second review in which cap, saicin has been called a derivative of homovanillic acid. In fact, capsaicin is the acylamide of vanillylamine and 8-methyl-6 trans-nonenoic acid. Acylamides of homovanillic acid are able to produce iden- tical effects to those of capsaicin 1, but the difference in chemical structure should not be ignored. To he precise, capsaicin is not a 'new' pharmacological tool, because it has been used for this purpose by the group of the late Nicholas Jancs6 (who is the father of G. Jancs6, cited in the article) for more than three decades. It is certainly true that inter- esting new aspects (selective substance P depletion and interaction with nerve growth factor) have only recently been discovered. It should also he stressed that capsaicin is a selective, useful tool in vitro. Capsaicin- sensitive neural responses of isolated organs can be completely abolished by the drug without affecting adrenergic, cholinergic, purinergic, or even some pep, tidergic neural responses. The irreversible nature of the blockade and the more than 1 000 times concentration range of its neurone-selective effect is particularly use- rid. The variety of methods of application of capsaicin is one of the main advantages of the drug. Its neurone-selective effect on sensory neurones resembles that of guanethidine on adrenergic neurones (neurone blockade with depletion after ini- tial excitation of the nerve endings, fol- lowed by similar ultrastructural changes after higher doses, or even neurotoxic degeneration when it is given to neonates). On the basis of this analogy capsaicin and its congeners have been classified as sen- sory neurone blocking agents 1." @default.
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- W2035880334 date "1983-01-01" @default.
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- W2035880334 title "Capsaicin: hot new pharmacological tool" @default.
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- W2035880334 doi "https://doi.org/10.1016/0165-6147(83)90297-3" @default.
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