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• W2035880771 abstract "The thalamic synapses relay peripheral sensory information to the cortex, and constitute an important part of the thalamocortical network that generates oscillatory activities responsible for different vigilance (sleep and wakefulness) states. However, the modulation of thalamic synaptic transmission by potential sleep regulators, especially by combination of regulators in physiological scenarios, is not fully characterized. We found that somnogen adenosine itself acts similar to wake-promoting serotonin, both decreasing synaptic strength as well as short-term depression, at the retinothalamic synapse. We then combined the two modulators considering the coexistence of them in the hypnagogic (sleep-onset) state. Adenosine plus serotonin results in robust synergistic inhibition of synaptic strength and dramatic transformation of short-term synaptic depression to facilitation. These synaptic effects are not achievable with a single modulator, and are consistent with a high signal-to-noise ratio but a low level of signal transmission through the thalamus appropriate for slow-wave sleep. This study for the first time demonstrates that the sleep-regulatory modulators may work differently when present in combination than present singly in terms of shaping information flow in the thalamocortical network. The major synaptic characters such as the strength and short-term plasticity can be profoundly altered by combination of modulators based on physiological considerations." @default.
• W2035880771 created "2016-06-24" @default.
• W2035880771 creator A5015972707 @default.
• W2035880771 creator A5059212851 @default.
• W2035880771 creator A5071289172 @default.
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• W2035880771 date "2013-11-13" @default.
• W2035880771 modified "2023-10-02" @default.
• W2035880771 title "Thalamic synaptic transmission of sensory information modulated by synergistic interaction of adenosine and serotonin" @default.
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• W2035880771 doi "https://doi.org/10.1111/jnc.12499" @default.
• W2035880771 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24147740" @default.
• W2035880771 hasPublicationYear "2013" @default.
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