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• W2035899636 abstract "The skin displays marked anatomical variation in thickness, colour and in the appendages that it carries. These regional distinctions arise in the embryo, likely founded on a combinatorial positional code of transcription factor expression. Throughout adult life, the skin's distinct anatomy is maintained through both cell autonomous epigenetic processes and by mesenchymal-epithelial induction. Despite the readily apparent anatomical differences in skin characteristics across the body, several fundamental questions regarding how such regional differences first arise and then persist are unresolved. However, it is clear that the skin's positional code is at the molecular level far more detailed than that discernible at the phenotypic level. This provides a latent reservoir of anatomical complexity ready to surface if perturbed by mutation, hormonal changes, ageing or experiment." @default.
• W2035899636 created "2016-06-24" @default.
• W2035899636 creator A5011731295 @default.
• W2035899636 creator A5079625823 @default.
• W2035899636 date "2014-01-01" @default.
• W2035899636 modified "2023-10-16" @default.
• W2035899636 title "Regionalisation of the skin" @default.
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• W2035899636 doi "https://doi.org/10.1016/j.semcdb.2013.12.007" @default.
• W2035899636 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24361971" @default.
• W2035899636 hasPublicationYear "2014" @default.
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