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• W2035909968 startingPage "662" @default.
• W2035909968 abstract "During adolescence there is a loss of approximately 30% of the synapses formed in the cortex during childhood. Comprehensive studies of the visual cortex show that this loss of synapses does not occur as a consequence of less appropriate projections being eliminated in favour of more appropriate ones. Rather it seems that synapses with low efficacy for transmission are eliminated in favour of those with higher efficacy. The loss of low-efficacy synapses is known, on theoretical grounds, to enhance the function of neural networks, but large synapse losses lead to failure of network function. In the dorsolateral prefrontal cortex (DLPC) of those suffering from schizophrenia the number of synapses is relatively very low, approximately 60% lower than that observed in normal childhood. It is not known if this is due to an additional loss over that during normal adolescence or whether it results from a failure to form a normal complement of synapses during childhood. The first study of synapse loss in the mammalian nervous system was made on the neuromuscular junction at Sydney University in 1974. Since then this junction has provided principal insights into the molecular basis of synapse formation and regression, so providing a paradigm for investigations of these phenomena in the DLPC. For example the molecules muscle-specific receptor tyrosine kinase (MuSK), agrin and neuregulin have been identified and their critical roles in the formation and maintenance of synapses elucidated. Loss of function of MuSK or agrin leads to failure of neuromuscular synapse formation as well as a loss of approximately 30% of excitatory synapses in the cortex. Similar synapse loss occurs on failure of neuregulin in vitro and of neuroligin in vivo. It is suggested that three important questions need to be answered: first, over what development period are the synapse numbers in DLPC of subjects with schizophrenia lower than normal; second, what are the relative importance of MuSK/agrin, neuregulin/ErB and neurexin/neuroligin in synapse formation and regression in the DLPC; and third, to what extent have these molecules gone awry in schizophrenia." @default.
• W2035909968 created "2016-06-24" @default.
• W2035909968 creator A5059824940 @default.
• W2035909968 date "2008-01-01" @default.
• W2035909968 modified "2023-09-26" @default.
• W2035909968 title "Dual Constraints on Synapse Formation and Regression in Schizophrenia: Neuregulin, Neuroligin, Dysbindin, DISC1, MuSK and Agrin" @default.
• W2035909968 cites W1496503316 @default.
• W2035909968 cites W1546762987 @default.
• W2035909968 cites W1579259266 @default.
• W2035909968 cites W1600404162 @default.
• W2035909968 cites W1602339006 @default.
• W2035909968 cites W172453174 @default.
• W2035909968 cites W1885585690 @default.
• W2035909968 cites W1893758837 @default.
• W2035909968 cites W1939596644 @default.
• W2035909968 cites W1950026089 @default.
• W2035909968 cites W1963008911 @default.
• W2035909968 cites W1964688937 @default.
• W2035909968 cites W1966727055 @default.
• W2035909968 cites W1967087306 @default.
• W2035909968 cites W1969958128 @default.
• W2035909968 cites W1970716291 @default.
• W2035909968 cites W1971233689 @default.
• W2035909968 cites W1972777532 @default.
• W2035909968 cites W1973854911 @default.
• W2035909968 cites W1977795395 @default.
• W2035909968 cites W1979774735 @default.
• W2035909968 cites W1979791151 @default.
• W2035909968 cites W1980073907 @default.
• W2035909968 cites W1980120506 @default.
• W2035909968 cites W1982142913 @default.
• W2035909968 cites W1984126567 @default.
• W2035909968 cites W1988021126 @default.
• W2035909968 cites W1990122129 @default.
• W2035909968 cites W1990472710 @default.
• W2035909968 cites W1990848854 @default.
• W2035909968 cites W1992606972 @default.
• W2035909968 cites W1992902151 @default.
• W2035909968 cites W1994438034 @default.
• W2035909968 cites W1996545009 @default.
• W2035909968 cites W1996819439 @default.
• W2035909968 cites W2000815470 @default.
• W2035909968 cites W2002192892 @default.
• W2035909968 cites W2004077068 @default.
• W2035909968 cites W2004826704 @default.
• W2035909968 cites W2004887039 @default.
• W2035909968 cites W2006401386 @default.
• W2035909968 cites W2007270186 @default.
• W2035909968 cites W2009355776 @default.
• W2035909968 cites W2010911134 @default.
• W2035909968 cites W2012648981 @default.
• W2035909968 cites W2013895597 @default.
• W2035909968 cites W2016291340 @default.
• W2035909968 cites W2016712421 @default.
• W2035909968 cites W2017497701 @default.
• W2035909968 cites W2017589933 @default.
• W2035909968 cites W2017720905 @default.
• W2035909968 cites W2018710502 @default.
• W2035909968 cites W2019184486 @default.
• W2035909968 cites W2022354453 @default.
• W2035909968 cites W2023094562 @default.
• W2035909968 cites W2024701323 @default.
• W2035909968 cites W2025011978 @default.
• W2035909968 cites W2025260177 @default.
• W2035909968 cites W2027691566 @default.
• W2035909968 cites W2029037348 @default.
• W2035909968 cites W2033021091 @default.
• W2035909968 cites W2035252427 @default.
• W2035909968 cites W2036022156 @default.
• W2035909968 cites W2036538226 @default.
• W2035909968 cites W2036879415 @default.
• W2035909968 cites W2039467550 @default.
• W2035909968 cites W2039932116 @default.
• W2035909968 cites W2041559782 @default.
• W2035909968 cites W2041875936 @default.
• W2035909968 cites W2042325100 @default.
• W2035909968 cites W2043212231 @default.
• W2035909968 cites W2044323703 @default.
• W2035909968 cites W2044374250 @default.
• W2035909968 cites W2044634543 @default.
• W2035909968 cites W2045997854 @default.
• W2035909968 cites W2046013073 @default.
• W2035909968 cites W2047425155 @default.
• W2035909968 cites W2048595403 @default.
• W2035909968 cites W2049132488 @default.
• W2035909968 cites W2049733177 @default.
• W2035909968 cites W2051965165 @default.
• W2035909968 cites W2053120614 @default.
• W2035909968 cites W2057158750 @default.
• W2035909968 cites W2060587133 @default.
• W2035909968 cites W2061432570 @default.
• W2035909968 cites W2061684042 @default.
• W2035909968 cites W2064128011 @default.
• W2035909968 cites W2068663043 @default.
• W2035909968 cites W2069651075 @default.
• W2035909968 cites W2071090720 @default.
• W2035909968 cites W2071889438 @default.
• W2035909968 cites W2072060283 @default.

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