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• W2035913504 abstract "Ataxia-telangiectasia (A-T), an inherited disorder giving radiation sensitivity and cancer-proneness, is discussed in terms of a defect in ability to repair DNA damage. A new assay using damaged recombinant DNA molecules suggests that the fidelity of repair of DNA double-strand breaks is reduced in an A-T cell line. Specific chromosomal changes in some A-T patients appear to be associated with cancer induction, and it is suggested that these could be linked to a DNA repair-fidelity defect. However, a general correlation between radiosensitivity and cancer-proneness is difficult to establish at present, partly because of diversity in radiosensitivity in the normal population." @default.
• W2035913504 created "2016-06-24" @default.
• W2035913504 creator A5091583144 @default.
• W2035913504 date "1989-08-01" @default.
• W2035913504 modified "2023-09-24" @default.
• W2035913504 title "Inherited sensitivity to X-rays in man" @default.
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• W2035913504 doi "https://doi.org/10.1002/bies.950110205" @default.
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