FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035914469> ?p ?o ?g. }

• W2035914469 endingPage "7607" @default.
• W2035914469 startingPage "7593" @default.
• W2035914469 abstract "ABSTRACT Cell culture-produced hepatitis C virus (HCV) has been subjected to up to 100 serial passages in human hepatoma cells in the absence or presence of different doses of alpha interferon (IFN-α). Virus survival, genetic changes, fitness levels, and phenotypic traits have been examined. While high initial IFN-α doses (increasing from 1 to 4 IU/ml) did not allow HCV survival beyond passage 40, a gradual exposure (from 0.25 to 10 IU/ml) allowed the virus to survive for at least 100 passages. The virus passaged in the presence of IFN-α acquired IFN-α resistance as evidenced by enhanced progeny production and viral protein expression in an IFN-α environment. A partial IFN-α resistance was also noted in populations passaged in the absence of IFN-α. All lineages acquired adaptative mutations, and multiple, nonsynonymous mutations scattered throughout the genome were present in IFN-α-selected populations. Comparison of consensus sequences indicates a dominance of synonymous versus nonsynonymous substitutions. IFN-α-resistant populations displayed decreased sensitivity to a combination of IFN-α and ribavirin. A phenotypic trait common to all assayed viral populations is the ability to increase shutoff host cell protein synthesis, accentuated in infections with IFN-α-selected populations carried out in the presence of IFN-α. The trait was associated with enhanced phosphorylation of protein kinase R (PKR) and eIF2α, although other contributing factors are likely. The results suggest that multiple, independent mutational pathways can confer IFN-α resistance to HCV and might explain why no unified picture has been obtained regarding IFN-α resistance in vivo ." @default.
• W2035914469 created "2016-06-24" @default.
• W2035914469 creator A5010609839 @default.
• W2035914469 creator A5019683467 @default.
• W2035914469 creator A5030491198 @default.
• W2035914469 creator A5033538661 @default.
• W2035914469 creator A5035783315 @default.
• W2035914469 creator A5036992417 @default.
• W2035914469 creator A5054578489 @default.
• W2035914469 creator A5067368986 @default.
• W2035914469 creator A5069448022 @default.
• W2035914469 date "2013-07-01" @default.
• W2035914469 modified "2023-10-06" @default.
• W2035914469 title "Response of Hepatitis C Virus to Long-Term Passage in the Presence of Alpha Interferon: Multiple Mutations and a Common Phenotype" @default.
• W2035914469 cites W1501423372 @default.
• W2035914469 cites W1515293536 @default.
• W2035914469 cites W1541967458 @default.
• W2035914469 cites W1656291587 @default.
• W2035914469 cites W1939121468 @default.
• W2035914469 cites W1965396914 @default.
• W2035914469 cites W1968426124 @default.
• W2035914469 cites W1970408170 @default.
• W2035914469 cites W1972260831 @default.
• W2035914469 cites W1973597378 @default.
• W2035914469 cites W1975553990 @default.
• W2035914469 cites W1978130780 @default.
• W2035914469 cites W1978216180 @default.
• W2035914469 cites W1978883570 @default.
• W2035914469 cites W1979728902 @default.
• W2035914469 cites W1983624373 @default.
• W2035914469 cites W1983714443 @default.
• W2035914469 cites W1985433337 @default.
• W2035914469 cites W1989409598 @default.
• W2035914469 cites W1991702089 @default.
• W2035914469 cites W1994278598 @default.
• W2035914469 cites W1997249384 @default.
• W2035914469 cites W1997873455 @default.
• W2035914469 cites W1998238867 @default.
• W2035914469 cites W1998272398 @default.
• W2035914469 cites W2001674944 @default.
• W2035914469 cites W2003579943 @default.
• W2035914469 cites W2007987493 @default.
• W2035914469 cites W2008079733 @default.
• W2035914469 cites W2008847749 @default.
• W2035914469 cites W2010063387 @default.
• W2035914469 cites W2012929838 @default.
• W2035914469 cites W2014165835 @default.
• W2035914469 cites W2016589999 @default.
• W2035914469 cites W2017412627 @default.
• W2035914469 cites W2023127814 @default.
• W2035914469 cites W2023309777 @default.
• W2035914469 cites W2023402045 @default.
• W2035914469 cites W2024086482 @default.
• W2035914469 cites W2025236628 @default.
• W2035914469 cites W2026560201 @default.
• W2035914469 cites W2027252289 @default.
• W2035914469 cites W2027545702 @default.
• W2035914469 cites W2027868702 @default.
• W2035914469 cites W2028488386 @default.
• W2035914469 cites W2032094407 @default.
• W2035914469 cites W2035551330 @default.
• W2035914469 cites W2035566133 @default.
• W2035914469 cites W2038967570 @default.
• W2035914469 cites W2038987068 @default.
• W2035914469 cites W2044037901 @default.
• W2035914469 cites W2044193462 @default.
• W2035914469 cites W2046714103 @default.
• W2035914469 cites W2047661983 @default.
• W2035914469 cites W2047829391 @default.
• W2035914469 cites W2049115723 @default.
• W2035914469 cites W2052160923 @default.
• W2035914469 cites W2055514375 @default.
• W2035914469 cites W2055779218 @default.
• W2035914469 cites W2059457521 @default.
• W2035914469 cites W2063285149 @default.
• W2035914469 cites W2068259734 @default.
• W2035914469 cites W2073528237 @default.
• W2035914469 cites W2073918065 @default.
• W2035914469 cites W2075660007 @default.
• W2035914469 cites W2077546945 @default.
• W2035914469 cites W2079059990 @default.
• W2035914469 cites W2079317094 @default.
• W2035914469 cites W2083737806 @default.
• W2035914469 cites W2084742492 @default.
• W2035914469 cites W2089640290 @default.
• W2035914469 cites W2091554591 @default.
• W2035914469 cites W2093977114 @default.
• W2035914469 cites W2096372976 @default.
• W2035914469 cites W2097148041 @default.
• W2035914469 cites W2102518994 @default.
• W2035914469 cites W2104117639 @default.
• W2035914469 cites W2105322823 @default.
• W2035914469 cites W2107713887 @default.
• W2035914469 cites W2109134539 @default.
• W2035914469 cites W2110033892 @default.
• W2035914469 cites W2111283804 @default.
• W2035914469 cites W2112360308 @default.
• W2035914469 cites W2112876622 @default.

• next