Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035916711> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2035916711 abstract "Pancreatic adenocarcinoma is a highly aggressive disease with a propensity for metastasis early in its course. Pancreatic cancer stem cells (CSCs) have been thought to play a key role in this process. We previously found that pancreatic CSCs express increased levels of aldehyde dehydrogenase (ALDH) and at the time of diagnosis the presence of ALDH+ cells in primary tumors is associated with worse overall survival. The development of CSC-targeting strategies have largely focused on intrinsic signaling pathways, but normal stem cells are primarily regulated by the extracellular stem cell niche that consists of non-malignant cells and specific extracellular matrix (ECM) proteins. The densely fibrotic desmoplastic reaction (DR) is a common feature of pancreatic tumors, thus we examined the role of the ECM on pancreatic CSCs. We initially studied the distribution of ALDH+ cells in primary pancreatic tumors by immunohistochemistry and found that they were more frequently located at the invasive edge of tumors adjacent to the DR compared to the rest of the tumor ( Our data suggest that the interaction between pancreatic CSCs and the DR results in enhanced tumorigenicity and metastatic potential. Furthermore, the disruption of FAK signaling can inhibit pancreatic CSC function and may serve as a novel therapeutic strategy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2446. doi:10.1158/1538-7445.AM2011-2446" @default.
- W2035916711 created "2016-06-24" @default.
- W2035916711 creator A5010732001 @default.
- W2035916711 creator A5014265119 @default.
- W2035916711 creator A5027419360 @default.
- W2035916711 creator A5043567079 @default.
- W2035916711 creator A5048073439 @default.
- W2035916711 creator A5080727472 @default.
- W2035916711 creator A5082546072 @default.
- W2035916711 creator A5083345144 @default.
- W2035916711 date "2011-04-15" @default.
- W2035916711 modified "2023-09-26" @default.
- W2035916711 title "Abstract 2446: Targeting pancreatic cancer stem cells via the tumor microenvironment" @default.
- W2035916711 doi "https://doi.org/10.1158/1538-7445.am2011-2446" @default.
- W2035916711 hasPublicationYear "2011" @default.
- W2035916711 type Work @default.
- W2035916711 sameAs 2035916711 @default.
- W2035916711 citedByCount "0" @default.
- W2035916711 crossrefType "proceedings-article" @default.
- W2035916711 hasAuthorship W2035916711A5010732001 @default.
- W2035916711 hasAuthorship W2035916711A5014265119 @default.
- W2035916711 hasAuthorship W2035916711A5027419360 @default.
- W2035916711 hasAuthorship W2035916711A5043567079 @default.
- W2035916711 hasAuthorship W2035916711A5048073439 @default.
- W2035916711 hasAuthorship W2035916711A5080727472 @default.
- W2035916711 hasAuthorship W2035916711A5082546072 @default.
- W2035916711 hasAuthorship W2035916711A5083345144 @default.
- W2035916711 hasConcept C121608353 @default.
- W2035916711 hasConcept C126322002 @default.
- W2035916711 hasConcept C142724271 @default.
- W2035916711 hasConcept C189165786 @default.
- W2035916711 hasConcept C2779013556 @default.
- W2035916711 hasConcept C2780210213 @default.
- W2035916711 hasConcept C28328180 @default.
- W2035916711 hasConcept C502942594 @default.
- W2035916711 hasConcept C55427017 @default.
- W2035916711 hasConcept C71924100 @default.
- W2035916711 hasConcept C86803240 @default.
- W2035916711 hasConcept C95444343 @default.
- W2035916711 hasConceptScore W2035916711C121608353 @default.
- W2035916711 hasConceptScore W2035916711C126322002 @default.
- W2035916711 hasConceptScore W2035916711C142724271 @default.
- W2035916711 hasConceptScore W2035916711C189165786 @default.
- W2035916711 hasConceptScore W2035916711C2779013556 @default.
- W2035916711 hasConceptScore W2035916711C2780210213 @default.
- W2035916711 hasConceptScore W2035916711C28328180 @default.
- W2035916711 hasConceptScore W2035916711C502942594 @default.
- W2035916711 hasConceptScore W2035916711C55427017 @default.
- W2035916711 hasConceptScore W2035916711C71924100 @default.
- W2035916711 hasConceptScore W2035916711C86803240 @default.
- W2035916711 hasConceptScore W2035916711C95444343 @default.
- W2035916711 hasLocation W20359167111 @default.
- W2035916711 hasOpenAccess W2035916711 @default.
- W2035916711 hasPrimaryLocation W20359167111 @default.
- W2035916711 hasRelatedWork W1882285702 @default.
- W2035916711 hasRelatedWork W1975522719 @default.
- W2035916711 hasRelatedWork W1979983936 @default.
- W2035916711 hasRelatedWork W1982184962 @default.
- W2035916711 hasRelatedWork W1992899358 @default.
- W2035916711 hasRelatedWork W2011847905 @default.
- W2035916711 hasRelatedWork W2050577279 @default.
- W2035916711 hasRelatedWork W2054191273 @default.
- W2035916711 hasRelatedWork W2055070058 @default.
- W2035916711 hasRelatedWork W2058400226 @default.
- W2035916711 hasRelatedWork W2090601702 @default.
- W2035916711 hasRelatedWork W2214146201 @default.
- W2035916711 hasRelatedWork W2326129569 @default.
- W2035916711 hasRelatedWork W2333330507 @default.
- W2035916711 hasRelatedWork W2520133312 @default.
- W2035916711 hasRelatedWork W2763008894 @default.
- W2035916711 hasRelatedWork W2885204238 @default.
- W2035916711 hasRelatedWork W2953452437 @default.
- W2035916711 hasRelatedWork W3009563947 @default.
- W2035916711 hasRelatedWork W3112014905 @default.
- W2035916711 isParatext "false" @default.
- W2035916711 isRetracted "false" @default.
- W2035916711 magId "2035916711" @default.
- W2035916711 workType "article" @default.