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- W2035921504 abstract "Abstract The segregation of murine leukemia virus (MuLV) loci in backcrosses of AKR mice with NIH Swiss, C57BL/6, and BALB/c mice was followed by serological and virological assays as well as by DNA hybridization. In the backcross, NIH × (NIH × AKR), three main phenotypes of virus expression were observed, including viremic mice without any detectable free antibody against MuLV, nonviremic mice with high titers of antibody, and nonviremic mice without any detectable antibody. Of the three phenotypes, only the nonviremic, no-antibody mice were segregants for the lack of MuLV proviral DNA by DNA hybridization, by AKR-MuLV type-specific antigen expression, and by second backcross analysis. These mice represented approximately 13% of the population, suggesting the presence of three AKR-MuLV loci in AKR mice. In backcrosses of AKR mice with C57BL/6 mice only the antibody-positive, nonviremic and no-antibody, nonviremic phenotypes were observed. The segregation of AKR-MuLV loci in these crosses, analyzed serologically, was also consistent with the presence of three AKR-MuLV loci in AKR mice." @default.
- W2035921504 created "2016-06-24" @default.
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- W2035921504 date "1978-06-01" @default.
- W2035921504 modified "2023-09-23" @default.
- W2035921504 title "Serological and virological analysis of NIH (NIH × AKR) mice: Evidence for three AKR murine leukemia virus loci" @default.
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- W2035921504 doi "https://doi.org/10.1016/0042-6822(78)90134-4" @default.
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