FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035922014> ?p ?o ?g. }

• W2035922014 endingPage "507" @default.
• W2035922014 startingPage "498" @default.
• W2035922014 abstract "Summary. 8-Hydroxydeoxyguanosine (8-OHdG) is a promutagenic DNA lesion produced by hydroxyl radicals and is recognized as a useful marker in estimating DNA damage induced by oxidative stress. The aim of this study was to clarify the clinical significance of hepatic 8-OHdG levels in patients with chronic viral hepatitis. Hepatic 8-OHdG accumulation was investigated in patients with chronic hepatitis C (CH-C) (n = 77) and chronic hepatitis B (CH-B) (n = 34) by immunohistochemical staining of liver biopsy samples. 8-OHdG positive hepatocytes were significantly higher in patients with CH-C compared to CH-B (median 55.0 vs 18.8 cells/105 μm2, P < 0.0001). The number of positive hepatocytes significantly increased with the elevation of serum aminotransferase levels, especially in CH-C patients (8-OHdG vs alanine aminotransferase (ALT)/aspartate aminotrasferase (AST) were r = 0.738/0.720 in CH-C and 0.506/0.515 in CH-B). 8-OHdG reactivity was strongly correlated with body and hepatic iron storage markers in CH-C (vs serum ferritin, r = 0.615; vs hepatic total iron score, r = 0.520; vs hepatic hepcidin mRNA levels, r = 0.571), although it was related to serum HBV-DNA titers (r = 0.540) and age of patients (r = –0.559) in CH-B. These results indicate that hepatic oxidative DNA damage is common in chronic viral hepatitis, in particular chronic HCV-infected patients, suggesting a possible link between chronic hepatic inflammation and hepatocarcinogenesis. The strong positive correlation between hepatic DNA damage and iron overload suggests that iron content is one of the most likely mediators of hepatic oxidative stress and iron reduction may be beneficial to reduce the incidence of hepatic cancer in CH-C patients." @default.
• W2035922014 created "2016-06-24" @default.
• W2035922014 creator A5007801419 @default.
• W2035922014 creator A5017364653 @default.
• W2035922014 creator A5026033071 @default.
• W2035922014 creator A5034118045 @default.
• W2035922014 creator A5042135022 @default.
• W2035922014 creator A5060850219 @default.
• W2035922014 creator A5070158905 @default.
• W2035922014 creator A5077773100 @default.
• W2035922014 creator A5080990617 @default.
• W2035922014 creator A5085163578 @default.
• W2035922014 date "2008-07-01" @default.
• W2035922014 modified "2023-10-16" @default.
• W2035922014 title "Comparison of hepatic oxidative DNA damage in patients with chronic hepatitis B and C" @default.
• W2035922014 cites W1602543439 @default.
• W2035922014 cites W160412982 @default.
• W2035922014 cites W1795028094 @default.
• W2035922014 cites W1903511389 @default.
• W2035922014 cites W1973334349 @default.
• W2035922014 cites W1974614940 @default.
• W2035922014 cites W1977113145 @default.
• W2035922014 cites W1977898965 @default.
• W2035922014 cites W1979139937 @default.
• W2035922014 cites W1979230311 @default.
• W2035922014 cites W1986773920 @default.
• W2035922014 cites W2000078170 @default.
• W2035922014 cites W2010597170 @default.
• W2035922014 cites W2011844018 @default.
• W2035922014 cites W2012698685 @default.
• W2035922014 cites W2015098253 @default.
• W2035922014 cites W2024897106 @default.
• W2035922014 cites W2032611112 @default.
• W2035922014 cites W2039612317 @default.
• W2035922014 cites W2056922235 @default.
• W2035922014 cites W2061706457 @default.
• W2035922014 cites W2069726649 @default.
• W2035922014 cites W2071037772 @default.
• W2035922014 cites W2071850731 @default.
• W2035922014 cites W2161998284 @default.
• W2035922014 cites W2165201727 @default.
• W2035922014 cites W2400025420 @default.
• W2035922014 cites W4233694993 @default.
• W2035922014 cites W4239073631 @default.
• W2035922014 cites W4239108047 @default.
• W2035922014 cites W4241462015 @default.
• W2035922014 cites W4242654446 @default.
• W2035922014 cites W4256379614 @default.
• W2035922014 cites W8890124 @default.
• W2035922014 doi "https://doi.org/10.1111/j.1365-2893.2008.00972.x" @default.
• W2035922014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18331251" @default.
• W2035922014 hasPublicationYear "2008" @default.
• W2035922014 type Work @default.
• W2035922014 sameAs 2035922014 @default.
• W2035922014 citedByCount "112" @default.
• W2035922014 countsByYear W20359220142012 @default.
• W2035922014 countsByYear W20359220142013 @default.
• W2035922014 countsByYear W20359220142014 @default.
• W2035922014 countsByYear W20359220142015 @default.
• W2035922014 countsByYear W20359220142016 @default.
• W2035922014 countsByYear W20359220142017 @default.
• W2035922014 countsByYear W20359220142018 @default.
• W2035922014 countsByYear W20359220142019 @default.
• W2035922014 countsByYear W20359220142020 @default.
• W2035922014 countsByYear W20359220142021 @default.
• W2035922014 countsByYear W20359220142022 @default.
• W2035922014 countsByYear W20359220142023 @default.
• W2035922014 crossrefType "journal-article" @default.
• W2035922014 hasAuthorship W2035922014A5007801419 @default.
• W2035922014 hasAuthorship W2035922014A5017364653 @default.
• W2035922014 hasAuthorship W2035922014A5026033071 @default.
• W2035922014 hasAuthorship W2035922014A5034118045 @default.
• W2035922014 hasAuthorship W2035922014A5042135022 @default.
• W2035922014 hasAuthorship W2035922014A5060850219 @default.
• W2035922014 hasAuthorship W2035922014A5070158905 @default.
• W2035922014 hasAuthorship W2035922014A5077773100 @default.
• W2035922014 hasAuthorship W2035922014A5080990617 @default.
• W2035922014 hasAuthorship W2035922014A5085163578 @default.
• W2035922014 hasConcept C126322002 @default.
• W2035922014 hasConcept C142724271 @default.
• W2035922014 hasConcept C143425029 @default.
• W2035922014 hasConcept C185592680 @default.
• W2035922014 hasConcept C203014093 @default.
• W2035922014 hasConcept C2522874641 @default.
• W2035922014 hasConcept C2775934546 @default.
• W2035922014 hasConcept C2776029263 @default.
• W2035922014 hasConcept C2776151105 @default.
• W2035922014 hasConcept C2776768029 @default.
• W2035922014 hasConcept C2776914184 @default.
• W2035922014 hasConcept C2777766500 @default.
• W2035922014 hasConcept C2778319317 @default.
• W2035922014 hasConcept C3020491458 @default.
• W2035922014 hasConcept C552990157 @default.
• W2035922014 hasConcept C55493867 @default.
• W2035922014 hasConcept C71924100 @default.
• W2035922014 hasConcept C90924648 @default.
• W2035922014 hasConceptScore W2035922014C126322002 @default.
• W2035922014 hasConceptScore W2035922014C142724271 @default.

• next