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- W2035931009 abstract "Since diazepam-ketamine induction sequences in healthy humans cause no significant increase in plasma free-norepinephrine and epinephrine, blood pressure and heart rate, we have frequently used a diazepam-ketamine pancuronium sequence for induction of anesthesia in patients undergoing open-heart surgery. In order to assess objectively the influence of pancuronium on sympathetic activity in cardiac patients, plasma free-norepinephrine and free-epinephrine were measured by Vend-salu's method in the arterial blood of 12 patients who were to undergo valve replacement or coronary bypass. At the same time, arterial pressure measured by a strain-gauge from the radial artery and heart rate measured by ECG were continuously recorded during induction with diazepam 0.3 mg/kg, followed 10 min later by ketamine 2.0 mg/kg. No significant changes occurred in these parameters before pancuronium administration. Plasma free-norepinephrine and free-epinephrine concentrations before and 5 min after pancuronium 0.1 mg/kg given over a 1-min period were 0.42±0.05 (mean ± s.e.mean) and 0.45±0.05 ng/ml (P>0.1) and 0.01±0.003 and 0.02±0.009 ng/ml (P>0.1), respectively. A significant increase in heart rate followed pancuronium administration from 75.0±4.0 to 90.0±6.0 beatslmin (P<0.001). The corresponding systolic and diastolic direct arterial pressures were 148.0±9.4/74.0±6.0 and 153.0±8.3/81.0±5.2 mmHg (P>0.05). Although a statistically significant increase in heart rate was observed after pancuronium, no significant increase was found in plasma free-norepinephrine, epinephrine or direct arterial pressure." @default.
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- W2035931009 date "1978-08-01" @default.
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- W2035931009 title "Effect of Pancuronium on Plasma Free-Norepinephrine and Epinephrine in Adult Cardiac Surgical Patients" @default.
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- W2035931009 doi "https://doi.org/10.1111/j.1399-6576.1978.tb01318.x" @default.
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