FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035951567> ?p ?o ?g. }

• W2035951567 endingPage "351" @default.
• W2035951567 startingPage "345" @default.
• W2035951567 abstract "1 This study aimed to assess the effect of cyclopiazonic acid (CPA), an inhibitor of sarcoplasmic reticulum calcium (Ca) pump, against contractile responses produced by selective tachykinin NK1 and NK2 receptor agonists, [Sar9]substance P (SP) sulfone and [beta Ala8]neurokinin A (NKA) (4-10), respectively, on the circular muscle of guinea-pig colon. All experiments were performed in the presence of atropine (1 microM) and indomethacin (10 microM). 2 In organ bath experiments, a submaximally equieffective concentration of the two agonists (10 nM) was selected: [Sar9]SP sulfone (10 nM) produced a biphasic contraction, the two amplitudes averaging 75 +/- 2 and 43 +/- 3% of the maximal response to KCl (80 mM) at 1 and 15 min from application of the agonist, respectively. CPA (3 microM for 60 min) slightly reduced the phasic response to [Sar9]SP sulfone (16 +/- 4% inhibition) and markedly suppressed the tonic component (89 +/- 3% inhibition). 3 The contraction produced by [beta Ala8]NKA (4-10) (10 nM) was more sustained than that induced by the NK1 receptor agonist: it averaged 69 +/- 5 and 73 +/- 4% of the response to KCl at 1 and 15 min from application of the agonist, respectively. CPA slightly and evenly depressed the response to [beta Ala8]NKA (4-10) (18 +/- 7 and 21 +/- 5% inhibition at 1 and 15 min). 4 In the presence of tachykinin NK1 and NK2 receptor antagonists (SR 140333 and MEN 10627, respectively, 1 microM each) and of L-nitroarginine (100 microM), KCl (40 mM) produced a distinct phasic and tonic contraction which was suppressed by 1 mM nifedipine. CPA (3 microM) did not affect the phasic contraction to KCl but abolished the tonic component of the response. 5 In the presence of 1 microM nifedipine, the response to [beta Ala8]NKA (4-10) was slightly depressed (32 +/- 6% inhibition) in its early component only, while the response to [Sar9]SP sulfone was abolished. CPA produced a slight inhibition (15 +/- 9 and 33 +/- 10% at 1 and 15 min, respectively) of the nifedipine-resistant response to [beta Ala8]NKA (4-10), an effect similar to that observed in the absence of nifedipine. Therefore, a large part of the response to [beta Ala8]NKA (4-10) persisted in the presence of both CPA and nifedipine. 6 In the sucrose gap, a prolonged superfusion with [Sar9]SP sulfone (0.1 microM for 5 min) produced sustained depolarization with superimposed spikes and contraction. CPA (3 microM) produced transient depolarization and contraction. In the presence of CPA, the initial responses (depolarization, spikes and contraction) to [Sar9]SP sulfone were unaffected but the sustained component of contraction was absent; the latter effect was accompanied by a suppression of spikes while the sustained depolarization was present. 7 We conclude that, during sustained depolarization produced by the NK1 receptor agonist, blockade of the sarcoplasmic reticulum Ca pump by CPA produces a faster Ca-dependent inactivation of Ca channels, thereby eliminating spikes and abolishing the tonic component of contraction. Ca mobilization/reuptake from a CPA-sensitive store seems to be of minor importance for regulating the NK2 receptor-mediated contractile responses." @default.
• W2035951567 created "2016-06-24" @default.
• W2035951567 creator A5007685909 @default.
• W2035951567 creator A5010124185 @default.
• W2035951567 creator A5074848272 @default.
• W2035951567 date "1997-02-01" @default.
• W2035951567 modified "2023-10-03" @default.
• W2035951567 title "Effect of cyclopiazonic acid on contractions produced by tachykinin NK1and NK2receptor agonists in the circular muscle of guinea-pig colon" @default.
• W2035951567 doi "https://doi.org/10.1046/j.1365-2680.1997.00470.x" @default.
• W2035951567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9610429" @default.
• W2035951567 hasPublicationYear "1997" @default.
• W2035951567 type Work @default.
• W2035951567 sameAs 2035951567 @default.
• W2035951567 citedByCount "2" @default.
• W2035951567 crossrefType "journal-article" @default.
• W2035951567 hasAuthorship W2035951567A5007685909 @default.
• W2035951567 hasAuthorship W2035951567A5010124185 @default.
• W2035951567 hasAuthorship W2035951567A5074848272 @default.
• W2035951567 hasConcept C118303440 @default.
• W2035951567 hasConcept C126322002 @default.
• W2035951567 hasConcept C134018914 @default.
• W2035951567 hasConcept C163415756 @default.
• W2035951567 hasConcept C170493617 @default.
• W2035951567 hasConcept C185592680 @default.
• W2035951567 hasConcept C2776050358 @default.
• W2035951567 hasConcept C2776533618 @default.
• W2035951567 hasConcept C2777056410 @default.
• W2035951567 hasConcept C2778938600 @default.
• W2035951567 hasConcept C2779996123 @default.
• W2035951567 hasConcept C29852270 @default.
• W2035951567 hasConcept C4141045 @default.
• W2035951567 hasConcept C519063684 @default.
• W2035951567 hasConcept C55938493 @default.
• W2035951567 hasConcept C71924100 @default.
• W2035951567 hasConceptScore W2035951567C118303440 @default.
• W2035951567 hasConceptScore W2035951567C126322002 @default.
• W2035951567 hasConceptScore W2035951567C134018914 @default.
• W2035951567 hasConceptScore W2035951567C163415756 @default.
• W2035951567 hasConceptScore W2035951567C170493617 @default.
• W2035951567 hasConceptScore W2035951567C185592680 @default.
• W2035951567 hasConceptScore W2035951567C2776050358 @default.
• W2035951567 hasConceptScore W2035951567C2776533618 @default.
• W2035951567 hasConceptScore W2035951567C2777056410 @default.
• W2035951567 hasConceptScore W2035951567C2778938600 @default.
• W2035951567 hasConceptScore W2035951567C2779996123 @default.
• W2035951567 hasConceptScore W2035951567C29852270 @default.
• W2035951567 hasConceptScore W2035951567C4141045 @default.
• W2035951567 hasConceptScore W2035951567C519063684 @default.
• W2035951567 hasConceptScore W2035951567C55938493 @default.
• W2035951567 hasConceptScore W2035951567C71924100 @default.
• W2035951567 hasIssue "6" @default.
• W2035951567 hasLocation W20359515671 @default.
• W2035951567 hasLocation W20359515672 @default.
• W2035951567 hasOpenAccess W2035951567 @default.
• W2035951567 hasPrimaryLocation W20359515671 @default.
• W2035951567 hasRelatedWork W1920320614 @default.
• W2035951567 hasRelatedWork W1967866503 @default.
• W2035951567 hasRelatedWork W1982180136 @default.
• W2035951567 hasRelatedWork W2022692549 @default.
• W2035951567 hasRelatedWork W2030203734 @default.
• W2035951567 hasRelatedWork W2035951567 @default.
• W2035951567 hasRelatedWork W2039566725 @default.
• W2035951567 hasRelatedWork W2068564242 @default.
• W2035951567 hasRelatedWork W2092252842 @default.
• W2035951567 hasRelatedWork W2416289859 @default.
• W2035951567 hasVolume "17" @default.
• W2035951567 isParatext "false" @default.
• W2035951567 isRetracted "false" @default.
• W2035951567 magId "2035951567" @default.
• W2035951567 workType "article" @default.