FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2035962912> ?p ?o ?g. }

• W2035962912 endingPage "1240" @default.
• W2035962912 startingPage "1234" @default.
• W2035962912 abstract "BACKGROUND The 12 members of the MAGE gene family encode tumor specific antigens that are recognized by autologous cytotoxic T lymphocytes (CTL). The MAGE genes are expressed not only in melanoma but in the other malignant tumors as well. There is, however, little information on their expression in hepatocellular carcinoma (HCC). The authors thus studied the expression of the MAGE gene family in human HCC and discuss the possibility of specific immunotherapy using MAGE peptides. METHODS Tumor tissue samples of HCC and paired nontumor tissues of the liver were obtained from 22 HCC patients. Total RNA was extracted and cDNA was synthesized. Polymerase chain reaction amplification using each MAGE gene specific primer was then performed to detect the expression of each MAGE gene. Immunoblotting and immunohistochemical analysis were performed to confirm the expression of MAGE-3 gene product in HCC. RESULTS The expression rate of each MAGE gene was as follows: MAGE-1 and -3 were expressed in approximately 68% of the tumors; MAGE-8 was expressed in 46%; and MAGE-2, -6, -10, -11, and -12 were expressed in approximately 30%. Nineteen (86%) of 22 tumors expressed at least 1 MAGE gene. On the other hand, no expression was detected in the noncarcinomatous liver tissue specimens. Actual expression of the gene product of MAGE-3 was detected in 50% of tumors. Clinicopathologic data on the MAGE positive and negative cases were compared. Significant differences were observed between MAGE expression status and a few clinicopathologic factors; however, further investigation is required to elucidate these correlations completely. CONCLUSIONS These findings demonstrated that MAGE gene expression is frequent in HCC, thus suggesting that HCC patients may be good candidates for specific immunotherapy using MAGE peptides. Cancer 1999;85:1234–40. © 1999 American Cancer Society." @default.
• W2035962912 created "2016-06-24" @default.
• W2035962912 creator A5010975613 @default.
• W2035962912 creator A5016954071 @default.
• W2035962912 creator A5044489876 @default.
• W2035962912 creator A5067647817 @default.
• W2035962912 creator A5070068637 @default.
• W2035962912 creator A5075811653 @default.
• W2035962912 date "1999-03-15" @default.
• W2035962912 modified "2023-10-07" @default.
• W2035962912 title "Expression of the MAGE gene family in human hepatocellular carcinoma" @default.
• W2035962912 cites W1974864250 @default.
• W2035962912 cites W1977273255 @default.
• W2035962912 cites W1984869659 @default.
• W2035962912 cites W1989651038 @default.
• W2035962912 cites W1991952914 @default.
• W2035962912 cites W1999933709 @default.
• W2035962912 cites W2000397450 @default.
• W2035962912 cites W2006987944 @default.
• W2035962912 cites W2020042830 @default.
• W2035962912 cites W2024061385 @default.
• W2035962912 cites W2033135238 @default.
• W2035962912 cites W2033394004 @default.
• W2035962912 cites W2054168466 @default.
• W2035962912 cites W2063574986 @default.
• W2035962912 cites W2064167987 @default.
• W2035962912 cites W2073252143 @default.
• W2035962912 cites W2076421780 @default.
• W2035962912 cites W2076424593 @default.
• W2035962912 cites W2083988731 @default.
• W2035962912 cites W2089676451 @default.
• W2035962912 cites W2137998934 @default.
• W2035962912 cites W2139030523 @default.
• W2035962912 cites W2148368831 @default.
• W2035962912 cites W2149940155 @default.
• W2035962912 cites W2155765223 @default.
• W2035962912 doi "https://doi.org/10.1002/(sici)1097-0142(19990315)85:6<1234::aid-cncr4>3.0.co;2-7" @default.
• W2035962912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10189127" @default.
• W2035962912 hasPublicationYear "1999" @default.
• W2035962912 type Work @default.
• W2035962912 sameAs 2035962912 @default.
• W2035962912 citedByCount "72" @default.
• W2035962912 countsByYear W20359629122012 @default.
• W2035962912 countsByYear W20359629122013 @default.
• W2035962912 countsByYear W20359629122014 @default.
• W2035962912 countsByYear W20359629122015 @default.
• W2035962912 countsByYear W20359629122016 @default.
• W2035962912 countsByYear W20359629122017 @default.
• W2035962912 countsByYear W20359629122018 @default.
• W2035962912 countsByYear W20359629122019 @default.
• W2035962912 countsByYear W20359629122020 @default.
• W2035962912 countsByYear W20359629122021 @default.
• W2035962912 countsByYear W20359629122022 @default.
• W2035962912 countsByYear W20359629122023 @default.
• W2035962912 crossrefType "journal-article" @default.
• W2035962912 hasAuthorship W2035962912A5010975613 @default.
• W2035962912 hasAuthorship W2035962912A5016954071 @default.
• W2035962912 hasAuthorship W2035962912A5044489876 @default.
• W2035962912 hasAuthorship W2035962912A5067647817 @default.
• W2035962912 hasAuthorship W2035962912A5070068637 @default.
• W2035962912 hasAuthorship W2035962912A5075811653 @default.
• W2035962912 hasBestOaLocation W20359629121 @default.
• W2035962912 hasConcept C104317684 @default.
• W2035962912 hasConcept C121608353 @default.
• W2035962912 hasConcept C126322002 @default.
• W2035962912 hasConcept C142724271 @default.
• W2035962912 hasConcept C150194340 @default.
• W2035962912 hasConcept C153911025 @default.
• W2035962912 hasConcept C178790620 @default.
• W2035962912 hasConcept C185592680 @default.
• W2035962912 hasConcept C187882448 @default.
• W2035962912 hasConcept C195286587 @default.
• W2035962912 hasConcept C204232928 @default.
• W2035962912 hasConcept C2777546739 @default.
• W2035962912 hasConcept C2777563447 @default.
• W2035962912 hasConcept C2777701055 @default.
• W2035962912 hasConcept C2778019345 @default.
• W2035962912 hasConcept C49105822 @default.
• W2035962912 hasConcept C502942594 @default.
• W2035962912 hasConcept C54355233 @default.
• W2035962912 hasConcept C5911399 @default.
• W2035962912 hasConcept C71924100 @default.
• W2035962912 hasConcept C86803240 @default.
• W2035962912 hasConceptScore W2035962912C104317684 @default.
• W2035962912 hasConceptScore W2035962912C121608353 @default.
• W2035962912 hasConceptScore W2035962912C126322002 @default.
• W2035962912 hasConceptScore W2035962912C142724271 @default.
• W2035962912 hasConceptScore W2035962912C150194340 @default.
• W2035962912 hasConceptScore W2035962912C153911025 @default.
• W2035962912 hasConceptScore W2035962912C178790620 @default.
• W2035962912 hasConceptScore W2035962912C185592680 @default.
• W2035962912 hasConceptScore W2035962912C187882448 @default.
• W2035962912 hasConceptScore W2035962912C195286587 @default.
• W2035962912 hasConceptScore W2035962912C204232928 @default.
• W2035962912 hasConceptScore W2035962912C2777546739 @default.
• W2035962912 hasConceptScore W2035962912C2777563447 @default.
• W2035962912 hasConceptScore W2035962912C2777701055 @default.
• W2035962912 hasConceptScore W2035962912C2778019345 @default.

• next